Summary

Name ABL2
Full Name Tyrosine-protein kinase ABL2
Synonyms Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG | ABLL, ARG
Primary ID P42684
Links - -
Type protein
Relations 20
Function Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation LGALS3 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PSMA7 0.588
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRK 0.68
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation CAT 0.345
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CAT 0.345
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABL2 0.49
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIVA1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GPX1 0.327
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Actin_cytoskeleton_reorganization 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ABL2 0.601
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png binding ABL2 0.2
Publications: 1 Organism: Mus Musculus