Entity Details

Name ABL2
ID P42684
Role substrate
Enzymatic Domains
SH3 107-167
PROSITE-ProRule
SH2 173-263
PROSITE-ProRule
Protein kinase 288-539
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PDGFRBABL2Tyr161QGWVPSNyITPVNSLphosphorylation
up-regulates activity		34144039SIGNOR-277306
PDGFRBABL2Tyr272KCNKPTVyGVSPIHDphosphorylation
up-regulates activity		34144039SIGNOR-277305
PDGFRBABL2Tyr310YVGVWKKySLTVAVKphosphorylation
up-regulates activity		34144039SIGNOR-277300
PDGFRBABL2–phosphorylation
up-regulates activity		34144039SIGNOR-279640
PDGFRBABL2Tyr299HKLGGGQyGEVYVGVphosphorylation
up-regulates activity		34144039SIGNOR-277301
RIN1ABL2–phosphorylation
up-regulates		15886098SIGNOR-136961
PDGFRBABL2Tyr116PNLFVALyDFVASGDphosphorylation
up-regulates activity		34144039SIGNOR-277304
PDGFRBABL2Tyr303GGQYGEVyVGVWKKYphosphorylation
up-regulates activity		34144039SIGNOR-277303
ABL2ABL2Tyr261GLVTTLHyPAPKCNKphosphorylation
up-regulates		15735735SIGNOR-134400
PDGFRBABL2Tyr139EKLRVLGyNQNGEWSphosphorylation
up-regulates activity		34144039SIGNOR-277302
ABL1ABL2Tyr261GLVTTLHyPAPKCNKphosphorylation
up-regulates		15735735SIGNOR-134396
ABL2ABL2Tyr261GLVTTLHyPAPKCNKphosphorylation
up-regulates quantity by stabilization		15735735SIGNOR-276033
ABL2ABL2Tyr439RLMTGDTyTAHAGAKphosphorylation
down-regulates quantity by destabilization		15735735SIGNOR-276032
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PDGFRBphosphorylation
up-regulates
→
ABL2
PTyr161		phosphorylation
up-regulates
→		ABL234144039SIGNOR-277306
PDGFRBphosphorylation
up-regulates
→
ABL2
PTyr272		phosphorylation
up-regulates
→		ABL234144039SIGNOR-277305
PDGFRBphosphorylation
up-regulates
→
ABL2
PTyr310		phosphorylation
up-regulates
→		ABL234144039SIGNOR-277300
PDGFRBphosphorylation
up-regulates
→
ABL2
PTyr299		phosphorylation
up-regulates
→		ABL234144039SIGNOR-277301
PDGFRBphosphorylation
up-regulates
→
ABL2
PTyr116		phosphorylation
up-regulates
→		ABL234144039SIGNOR-277304
PDGFRBphosphorylation
up-regulates
→
ABL2
PTyr303		phosphorylation
up-regulates
→		ABL234144039SIGNOR-277303
ABL2phosphorylation
up-regulates
→
ABL2
PTyr261		phosphorylation
up-regulates
→		ABL215735735SIGNOR-134400
PDGFRBphosphorylation
up-regulates
→
ABL2
PTyr139		phosphorylation
up-regulates
→		ABL234144039SIGNOR-277302
ABL1phosphorylation
up-regulates
→
ABL2
PTyr261		phosphorylation
up-regulates
→		ABL215735735SIGNOR-134396
ABL2phosphorylation
up-regulates
→
ABL2
PTyr261		phosphorylation
up-regulates
→		ABL215735735SIGNOR-276033
ABL2phosphorylation
up-regulates
→
ABL2
PTyr439		phosphorylation
down-regulates
⊣		ABL215735735SIGNOR-276032
Regulator Mechanism/Effect Target SIGNOR-ID
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-277306
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-277305
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-277300
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-279640
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-277301
RIN1phosphorylation
→
up-regulates 		ABL2SIGNOR-136961
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-277304
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-277303
ABL2phosphorylation
→
up-regulates 		ABL2SIGNOR-134400
PDGFRBphosphorylation
→
up-regulates activity 		ABL2SIGNOR-277302
ABL1phosphorylation
→
up-regulates 		ABL2SIGNOR-134396
ABL2phosphorylation
→
up-regulates quantity by stabilization 		ABL2SIGNOR-276033
ABL2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ABL2SIGNOR-276032