| Name | ABL2 |
| ID | P42684 |
| Role | substrate |
| Enzymatic Domains |
SH3 107-167 PROSITE-ProRule
SH2 173-263 PROSITE-ProRule
Protein kinase 288-539 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL2 | ABL2 | Tyr261 | GLVTTLHyPAPKCNK | phosphorylation up-regulates | 15735735 | SIGNOR-134400 |
| PDGFRB | ABL2 | Tyr272 | KCNKPTVyGVSPIHD | phosphorylation up-regulates activity | 34144039 | SIGNOR-277305 |
| PDGFRB | ABL2 | – | phosphorylation up-regulates activity | 34144039 | SIGNOR-279640 | |
| PDGFRB | ABL2 | Tyr139 | EKLRVLGyNQNGEWS | phosphorylation up-regulates activity | 34144039 | SIGNOR-277302 |
| PDGFRB | ABL2 | Tyr116 | PNLFVALyDFVASGD | phosphorylation up-regulates activity | 34144039 | SIGNOR-277304 |
| ABL1 | ABL2 | Tyr261 | GLVTTLHyPAPKCNK | phosphorylation up-regulates | 15735735 | SIGNOR-134396 |
| PDGFRB | ABL2 | Tyr310 | YVGVWKKySLTVAVK | phosphorylation up-regulates activity | 34144039 | SIGNOR-277300 |
| ABL2 | ABL2 | Tyr261 | GLVTTLHyPAPKCNK | phosphorylation up-regulates quantity by stabilization | 15735735 | SIGNOR-276033 |
| PDGFRB | ABL2 | Tyr299 | HKLGGGQyGEVYVGV | phosphorylation up-regulates activity | 34144039 | SIGNOR-277301 |
| PDGFRB | ABL2 | Tyr303 | GGQYGEVyVGVWKKY | phosphorylation up-regulates activity | 34144039 | SIGNOR-277303 |
| ABL2 | ABL2 | Tyr439 | RLMTGDTyTAHAGAK | phosphorylation down-regulates quantity by destabilization | 15735735 | SIGNOR-276032 |
| RIN1 | ABL2 | – | phosphorylation up-regulates | 15886098 | SIGNOR-136961 | |
| PDGFRB | ABL2 | Tyr161 | QGWVPSNyITPVNSL | phosphorylation up-regulates activity | 34144039 | SIGNOR-277306 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL2 | phosphorylation up-regulates → | ABL2 PTyr261 | phosphorylation up-regulates → | ABL2 | 15735735 | SIGNOR-134400 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr272 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277305 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr139 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277302 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr116 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277304 |
| ABL1 | phosphorylation up-regulates → | ABL2 PTyr261 | phosphorylation up-regulates → | ABL2 | 15735735 | SIGNOR-134396 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr310 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277300 |
| ABL2 | phosphorylation up-regulates → | ABL2 PTyr261 | phosphorylation up-regulates → | ABL2 | 15735735 | SIGNOR-276033 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr299 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277301 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr303 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277303 |
| ABL2 | phosphorylation up-regulates → | ABL2 PTyr439 | phosphorylation down-regulates ⊣ | ABL2 | 15735735 | SIGNOR-276032 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr161 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277306 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL2 | phosphorylation → up-regulates | ABL2 | SIGNOR-134400 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277305 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-279640 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277302 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277304 |
| ABL1 | phosphorylation → up-regulates | ABL2 | SIGNOR-134396 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277300 |
| ABL2 | phosphorylation → up-regulates quantity by stabilization | ABL2 | SIGNOR-276033 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277301 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277303 |
| ABL2 | phosphorylation down-regulates quantity by destabilization | ABL2 | SIGNOR-276032 |
| RIN1 | phosphorylation → up-regulates | ABL2 | SIGNOR-136961 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277306 |