| Name | FRK |
| ID | P42685 |
| Role | kinase |
| Enzymatic Domains |
SH3 42-110 PROSITE-ProRule
SH2 116-208 PROSITE-ProRule
Protein kinase 234-491 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FRK | EGFR | – | phosphorylation down-regulates activity | 23318459 | SIGNOR-279177 | |
| FRK | BRCA1 | Tyr1552 | HDLTETSyLPRQDLE | phosphorylation up-regulates quantity by stabilization | 29156836 | SIGNOR-275454 |
| FRK | YAP1 | Tyr391 | PFLNSGTyHSRDEST | phosphorylation down-regulates quantity by destabilization | 35723276 | SIGNOR-275455 |
| FRK | YAP1 | Tyr407 | SGLSMSSySVPRTPD | phosphorylation down-regulates quantity by destabilization | 35723276 | SIGNOR-275456 |
| FRK | YAP1 | Tyr444 | QQNRFPDyLEAIPGT | phosphorylation down-regulates quantity by destabilization | 35723276 | SIGNOR-275457 |
| FRK | PTEN | Tyr336 | NKDKANRyFSPNFKV | phosphorylation up-regulates activity | 19345329 | SIGNOR-278244 |
| FRK | PTEN | Tyr336 | NKDKANRyFSPNFKV | phosphorylation up-regulates quantity by stabilization | 19345329 | SIGNOR-275458 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FRK | phosphorylation up-regulates → | BRCA1 PTyr1552 | phosphorylation up-regulates → | BRCA1 | 29156836 | SIGNOR-275454 |
| FRK | phosphorylation up-regulates → | YAP1 PTyr391 | phosphorylation down-regulates ⊣ | YAP1 | 35723276 | SIGNOR-275455 |
| FRK | phosphorylation up-regulates → | YAP1 PTyr407 | phosphorylation down-regulates ⊣ | YAP1 | 35723276 | SIGNOR-275456 |
| FRK | phosphorylation up-regulates → | YAP1 PTyr444 | phosphorylation down-regulates ⊣ | YAP1 | 35723276 | SIGNOR-275457 |
| FRK | phosphorylation up-regulates → | PTEN PTyr336 | phosphorylation up-regulates → | PTEN | 19345329 | SIGNOR-278244 |
| FRK | phosphorylation up-regulates → | PTEN PTyr336 | phosphorylation up-regulates → | PTEN | 19345329 | SIGNOR-275458 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FRK | phosphorylation → down-regulates activity | EGFR | SIGNOR-279177 |
| FRK | phosphorylation → up-regulates quantity by stabilization | BRCA1 | SIGNOR-275454 |
| FRK | phosphorylation down-regulates quantity by destabilization | YAP1 | SIGNOR-275455 |
| FRK | phosphorylation down-regulates quantity by destabilization | YAP1 | SIGNOR-275456 |
| FRK | phosphorylation down-regulates quantity by destabilization | YAP1 | SIGNOR-275457 |
| FRK | phosphorylation → up-regulates activity | PTEN | SIGNOR-278244 |
| FRK | phosphorylation → up-regulates quantity by stabilization | PTEN | SIGNOR-275458 |