3.0
Summary
| Name |  FRKView Modifications |
| Full Name | Tyrosine-protein kinase FRK |
| Synonyms | FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5 | PTK5, RAK |
| Primary ID | P42685 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Inhibitors | regorafenib |
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FRK | up-regulates quantity by stabilization 
phosphorylation
|
BRCA1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FRK | up-regulates quantity by stabilization
phosphorylation
|
PTEN | 0.577 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FRK | down-regulates quantity by destabilization 
phosphorylation
|
YAP1 | 0.279 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | regorafenib | down-regulates activity
chemical inhibition
|
FRK | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |