| Name | LIFR |
| ID | P42702 |
| Role | substrate |
| Enzymatic Domains |
Fibronectin type-III 1 49-138 PROSITE-ProRule
Fibronectin type-III 2 335-434 PROSITE-ProRule
Fibronectin type-III 3 435-534 PROSITE-ProRule
Fibronectin type-III 4 538-629 PROSITE-ProRule
Fibronectin type-III 5 627-719 PROSITE-ProRule
Fibronectin type-III 6 724-833 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Gbeta | LIFR | – | phosphorylation down-regulates | 7777512 | SIGNOR-270001 | |
| MAPK3 | LIFR | Ser1044 | WNLVSPDsPRSIDSN | phosphorylation down-regulates | 7777512 | SIGNOR-32757 |
| MAPK1 | LIFR | Ser1044 | WNLVSPDsPRSIDSN | phosphorylation down-regulates | 7777512 | SIGNOR-32753 |
| ERK1/2 | LIFR | – | phosphorylation down-regulates | 7777512 | SIGNOR-270134 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | LIFR PSer1044 | phosphorylation down-regulates ⊣ | LIFR | 7777512 | SIGNOR-32757 |
| MAPK1 | phosphorylation up-regulates → | LIFR PSer1044 | phosphorylation down-regulates ⊣ | LIFR | 7777512 | SIGNOR-32753 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| Gbeta | phosphorylation down-regulates | LIFR | SIGNOR-270001 |
| MAPK3 | phosphorylation down-regulates | LIFR | SIGNOR-32757 |
| MAPK1 | phosphorylation down-regulates | LIFR | SIGNOR-32753 |
| ERK1/2 | phosphorylation down-regulates | LIFR | SIGNOR-270134 |