| Name | ZAP70 |
| ID | P43403 |
| Role | kinase |
| Enzymatic Domains |
SH2 1 10-102 PROSITE-ProRule
SH2 2 163-254 PROSITE-ProRule
Protein kinase 338-600 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | LAT | Tyr156 | ADEDEDDyHNPGYLV | phosphorylation up-regulates activity | 11368773 | SIGNOR-247018 |
| ZAP70 | LAT | Tyr161 | DDYHNPGyLVVLPDS | phosphorylation up-regulates activity | 11368773 | SIGNOR-247022 |
| ZAP70 | LAT | Tyr200 | SMESIDDyVNVPESG | phosphorylation up-regulates activity | 11368773 | SIGNOR-247026 |
| ZAP70 | LAT | Tyr220 | SLDGSREyVNVSQEL | phosphorylation up-regulates activity | 11368773 | SIGNOR-247030 |
| ZAP70 | LAT | Tyr255 | EEEGAPDyENLQELN | phosphorylation up-regulates activity | 11368773 | SIGNOR-247034 |
| ZAP70 | LAT | Tyr 132 | DYHNPGyLVVLPD | phosphorylation up-regulates activity | 29915297 | SIGNOR-274561 |
| ZAP70 | LAT | Tyr191 | LDGSREyVNVSQE | phosphorylation up-regulates activity | 29915297 | SIGNOR-274562 |
| ZAP70 | VAV1 | – | phosphorylation up-regulates activity | 23620790 | SIGNOR-278390 | |
| ZAP70 | MUC1 | Tyr1203 | IFPARDTyHPMSEYP | phosphorylation up-regulates activity | 14766232 | SIGNOR-247039 |
| ZAP70 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates | 9710204 | SIGNOR-59647 |
| ZAP70 | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation up-regulates | 9710204 | SIGNOR-59651 |
| ZAP70 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9710204 | SIGNOR-59659 |
| ZAP70 | ZAP70 | Tyr319 | TSVYESPySDPEELK | phosphorylation up-regulates activity | 10037717 | SIGNOR-247053 |
| ZAP70 | ZAP70 | Tyr315 | MPMDTSVyESPYSDP | phosphorylation up-regulates activity | 11828374 | SIGNOR-247048 |
| ZAP70 | ZAP70 | Tyr493 | LGADDSYyTARSAGK | phosphorylation up-regulates activity | 16049944 | SIGNOR-139098 |
| ZAP70 | ZAP70 | Tyr126 | RDAMVRDyVRQTWKL | phosphorylation up-regulates activity | 7961936 | SIGNOR-247044 |
| ZAP70 | ZAP70 | Tyr292 | DTLNSDGyTPEPARI | phosphorylation up-regulates activity | 8756661 | SIGNOR-43324 |
| ZAP70 | ZAP70 | Tyr492 | ALGADDSyYTARSAG | phosphorylation up-regulates activity | 8756661 | SIGNOR-226624 |
| ZAP70 | DUSP3 | Tyr138 | SPTLVIAyLMMRQKM | phosphorylation up-regulates | 12447358 | SIGNOR-95877 |
| ZAP70 | DUSP3 | Tyr138 | SPTLVIAyLMMRQKM | phosphorylation up-regulates activity | 12447358 | SIGNOR-276000 |
| ZAP70 | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates | 8702662 | SIGNOR-42956 |
| ZAP70 | LCP2 | Tyr128 | DGEDDGDyESPNEEE | phosphorylation up-regulates | 8702662 | SIGNOR-42960 |
| ZAP70 | LCP2 | Tyr145 | PVEDDADyEPPPSND | phosphorylation up-regulates | 8702662 | SIGNOR-42968 |
| ZAP70 | LCP2 | Tyr423 | NSLNEEWyVSYITRP | phosphorylation up-regulates | 8702662 | SIGNOR-42972 |
| ZAP70 | LCP2 | Tyr426 | NEEWYVSyITRPEAE | phosphorylation up-regulates | 8702662 | SIGNOR-42976 |
| ZAP70 | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates | 9047237 | SIGNOR-46855 |
| ZAP70 | LCP2 | Tyr128 | DGEDDGDyESPNEEE | phosphorylation up-regulates | 9047237 | SIGNOR-46859 |
| ZAP70 | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates activity | 12817019 | SIGNOR-102507 |
| ZAP70 | LCP2 | Tyr128 | DGEDDGDyESPNEEE | phosphorylation up-regulates activity | 12817019 | SIGNOR-102511 |
| ZAP70 | LCP2 | Tyr145 | PVEDDADyEPPPSND | phosphorylation up-regulates activity | 12817019 | SIGNOR-102515 |
| ZAP70 | SLC39A6 | – | phosphorylation up-regulates activity | 34394081 | SIGNOR-280165 | |
| ZAP70 | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates activity | 15735648 | SIGNOR-276030 |
| ZAP70 | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates activity | 15735648 | SIGNOR-134329 |
| ZAP70 | MAPK14 | – | phosphorylation up-regulates activity | 29440413 | SIGNOR-277385 | |
| ZAP70 | DBNL | Tyr334 | QAEEEAVyEEPPEQE | phosphorylation up-regulates | 14557276 | SIGNOR-118691 |
| ZAP70 | DBNL | Tyr344 | PPEQETFyEQPPLVQ | phosphorylation up-regulates | 14557276 | SIGNOR-118695 |
| ZAP70 | GAB2 | Tyr614 | KSTGSVDyLALDFQP | phosphorylation up-regulates activity | 11572860 | SIGNOR-110731 |
| ZAP70 | SH2B3 | Tyr273 | LEMPDNLyTFVLKVK | phosphorylation up-regulates | 9169414 | SIGNOR-48854 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | phosphorylation up-regulates → | LAT PTyr156 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247018 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr161 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247022 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr200 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247026 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr220 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247030 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr255 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247034 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr 132 | phosphorylation up-regulates → | LAT | 29915297 | SIGNOR-274561 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr191 | phosphorylation up-regulates → | LAT | 29915297 | SIGNOR-274562 |
| ZAP70 | phosphorylation up-regulates → | MUC1 PTyr1203 | phosphorylation up-regulates → | MUC1 | 14766232 | SIGNOR-247039 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59647 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59651 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59659 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr319 | phosphorylation up-regulates → | ZAP70 | 10037717 | SIGNOR-247053 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr315 | phosphorylation up-regulates → | ZAP70 | 11828374 | SIGNOR-247048 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr493 | phosphorylation up-regulates → | ZAP70 | 16049944 | SIGNOR-139098 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr126 | phosphorylation up-regulates → | ZAP70 | 7961936 | SIGNOR-247044 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr292 | phosphorylation up-regulates → | ZAP70 | 8756661 | SIGNOR-43324 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr492 | phosphorylation up-regulates → | ZAP70 | 8756661 | SIGNOR-226624 |
| ZAP70 | phosphorylation up-regulates → | DUSP3 PTyr138 | phosphorylation up-regulates → | DUSP3 | 12447358 | SIGNOR-95877 |
| ZAP70 | phosphorylation up-regulates → | DUSP3 PTyr138 | phosphorylation up-regulates → | DUSP3 | 12447358 | SIGNOR-276000 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42956 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr128 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42960 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr145 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42968 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr423 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42972 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr426 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42976 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 9047237 | SIGNOR-46855 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr128 | phosphorylation up-regulates → | LCP2 | 9047237 | SIGNOR-46859 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 12817019 | SIGNOR-102507 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr128 | phosphorylation up-regulates → | LCP2 | 12817019 | SIGNOR-102511 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr145 | phosphorylation up-regulates → | LCP2 | 12817019 | SIGNOR-102515 |
| ZAP70 | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-276030 |
| ZAP70 | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-134329 |
| ZAP70 | phosphorylation up-regulates → | DBNL PTyr334 | phosphorylation up-regulates → | DBNL | 14557276 | SIGNOR-118691 |
| ZAP70 | phosphorylation up-regulates → | DBNL PTyr344 | phosphorylation up-regulates → | DBNL | 14557276 | SIGNOR-118695 |
| ZAP70 | phosphorylation up-regulates → | GAB2 PTyr614 | phosphorylation up-regulates → | GAB2 | 11572860 | SIGNOR-110731 |
| ZAP70 | phosphorylation up-regulates → | SH2B3 PTyr273 | phosphorylation up-regulates → | SH2B3 | 9169414 | SIGNOR-48854 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247018 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247022 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247026 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247030 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247034 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-274561 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-274562 |
| ZAP70 | phosphorylation → up-regulates activity | VAV1 | SIGNOR-278390 |
| ZAP70 | phosphorylation → up-regulates activity | MUC1 | SIGNOR-247039 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59647 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59651 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59659 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-247053 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-247048 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-139098 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-247044 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-43324 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-226624 |
| ZAP70 | phosphorylation → up-regulates | DUSP3 | SIGNOR-95877 |
| ZAP70 | phosphorylation → up-regulates activity | DUSP3 | SIGNOR-276000 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42956 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42960 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42968 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42972 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42976 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-46855 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-46859 |
| ZAP70 | phosphorylation → up-regulates activity | LCP2 | SIGNOR-102507 |
| ZAP70 | phosphorylation → up-regulates activity | LCP2 | SIGNOR-102511 |
| ZAP70 | phosphorylation → up-regulates activity | LCP2 | SIGNOR-102515 |
| ZAP70 | phosphorylation → up-regulates activity | SLC39A6 | SIGNOR-280165 |
| ZAP70 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-276030 |
| ZAP70 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-134329 |
| ZAP70 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-277385 |
| ZAP70 | phosphorylation → up-regulates | DBNL | SIGNOR-118691 |
| ZAP70 | phosphorylation → up-regulates | DBNL | SIGNOR-118695 |
| ZAP70 | phosphorylation → up-regulates activity | GAB2 | SIGNOR-110731 |
| ZAP70 | phosphorylation → up-regulates | SH2B3 | SIGNOR-48854 |