Summary

Name ZAP70
Full Name Tyrosine-protein kinase ZAP-70
Synonyms 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase | SRK
Primary ID P43403
Links - -
Type protein
Relations 61
Pathways Mitochondrial dynamics in T cell exhaustion, P38 Signaling, T cell activation
Function Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation ZAP70 0.474
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation LCP2 0.804
Publications: 7 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation LCP2 0.804
Publications: 3 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation MUC1 0.449
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZAP70 0.2
Publications: 6 Organism: Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation LAT 0.769
Publications: 7 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation DUSP3 0.533
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DUSP3 0.533
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation ZAP70 0.617
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates img/direct-activation.png phosphorylation SH2B3 0.364
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation ZAP70 0.261
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation, binding ZAP70 0.617
Publications: 8 Organism: In Vitro, Mus Musculus, Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.474
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation DBNL 0.639
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.676
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ZAP70 0.705
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ZAP70 0.705
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZAP70 0.528
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB2 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.285
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png binding ZAP70 0.694
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding ZAP70 0.838
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ZAP70 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.365
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation VAV1 0.838
Publications: 1 Organism: Homo Sapiens