| Name | ZAP70 |
| ID | P43403 |
| Role | substrate |
| Enzymatic Domains |
SH2 1 10-102 PROSITE-ProRule
SH2 2 163-254 PROSITE-ProRule
Protein kinase 338-600 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | ZAP70 | Tyr315 | MPMDTSVyESPYSDP | phosphorylation up-regulates activity | 11828374 | SIGNOR-247048 |
| FYN | ZAP70 | – | phosphorylation up-regulates activity | 23150273 | SIGNOR-279043 | |
| LCK | ZAP70 | Tyr319 | TSVYESPySDPEELK | phosphorylation up-regulates activity | 10037717 | SIGNOR-251393 |
| ZAP70 | ZAP70 | Tyr292 | DTLNSDGyTPEPARI | phosphorylation up-regulates activity | 8756661 | SIGNOR-43324 |
| PTPRG | ZAP70 | Tyr315 | MPMDTSVyESPYSDP | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254733 |
| ZAP70 | ZAP70 | Tyr319 | TSVYESPySDPEELK | phosphorylation up-regulates activity | 10037717 | SIGNOR-247053 |
| ZAP70 | ZAP70 | Tyr126 | RDAMVRDyVRQTWKL | phosphorylation up-regulates activity | 7961936 | SIGNOR-247044 |
| LCK | ZAP70 | Tyr319 | TSVYESPySDPEELK | phosphorylation up-regulates activity | 10202147 | SIGNOR-273948 |
| PTPRG | ZAP70 | Tyr319 | TSVYESPySDPEELK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254734 |
| ZAP70 | ZAP70 | Tyr493 | LGADDSYyTARSAGK | phosphorylation up-regulates activity | 16049944 | SIGNOR-139098 |
| LCK | ZAP70 | Tyr69 | ERQLNGTyAIAGGKA | phosphorylation unknown | 7961936 | SIGNOR-251396 |
| LCK | ZAP70 | Tyr178 | EEAERKLySGAQTDG | phosphorylation unknown | 7961936 | SIGNOR-251392 |
| LCK | ZAP70 | Tyr493 | LGADDSYyTARSAGK | phosphorylation up-regulates activity | 8756661 | SIGNOR-226628 |
| SRC | ZAP70 | – | phosphorylation up-regulates activity | 34161759 | SIGNOR-279126 | |
| PTPRG | ZAP70 | Tyr292 | DTLNSDGyTPEPARI | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254732 |
| LCK | ZAP70 | Tyr493 | LGADDSYyTARSAGK | phosphorylation up-regulates activity | 7961936 | SIGNOR-251395 |
| MAPK14 | ZAP70 | Thr293 | TLNSDGYtPEPARIT | phosphorylation down-regulates activity | 29440413 | SIGNOR-277384 |
| LCK | ZAP70 | Tyr492 | ALGADDSyYTARSAG | phosphorylation up-regulates activity | 7642520 | SIGNOR-30429 |
| PTPN22 | ZAP70 | Tyr493 | LGADDSYyTARSAGK | dephosphorylation down-regulates | 16461343 | SIGNOR-144345 |
| LCK | ZAP70 | Tyr474 | VLLVNRHyAKISDFG | phosphorylation up-regulates activity | 9685404 | SIGNOR-249375 |
| ZAP70 | ZAP70 | Tyr492 | ALGADDSyYTARSAG | phosphorylation up-regulates activity | 8756661 | SIGNOR-226624 |
| DLG1 | ZAP70 | Tyr493 | LGADDSYyTARSAGK | phosphorylation up-regulates activity | 34960191 | SIGNOR-274142 |
| PTPN6 | ZAP70 | – | dephosphorylation down-regulates | 10458769 | SIGNOR-70237 | |
| PTPN22 | ZAP70 | Tyr493 | LGADDSYyTARSAGK | dephosphorylation down-regulates activity | 16461343 | SIGNOR-248838 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr315 | phosphorylation up-regulates → | ZAP70 | 11828374 | SIGNOR-247048 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr319 | phosphorylation up-regulates → | ZAP70 | 10037717 | SIGNOR-251393 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr292 | phosphorylation up-regulates → | ZAP70 | 8756661 | SIGNOR-43324 |
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr315 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254733 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr319 | phosphorylation up-regulates → | ZAP70 | 10037717 | SIGNOR-247053 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr126 | phosphorylation up-regulates → | ZAP70 | 7961936 | SIGNOR-247044 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr319 | phosphorylation up-regulates → | ZAP70 | 10202147 | SIGNOR-273948 |
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr319 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254734 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr493 | phosphorylation up-regulates → | ZAP70 | 16049944 | SIGNOR-139098 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr69 | phosphorylation down-regulates ⊣ | ZAP70 | 7961936 | SIGNOR-251396 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr178 | phosphorylation down-regulates ⊣ | ZAP70 | 7961936 | SIGNOR-251392 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr493 | phosphorylation up-regulates → | ZAP70 | 8756661 | SIGNOR-226628 |
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr292 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254732 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr493 | phosphorylation up-regulates → | ZAP70 | 7961936 | SIGNOR-251395 |
| MAPK14 | phosphorylation up-regulates → | ZAP70 PThr293 | phosphorylation down-regulates ⊣ | ZAP70 | 29440413 | SIGNOR-277384 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr492 | phosphorylation up-regulates → | ZAP70 | 7642520 | SIGNOR-30429 |
| PTPN22 | dephosphorylation down-regulates ⊣ | ZAP70 PTyr493 | dephosphorylation up-regulates → | ZAP70 | 16461343 | SIGNOR-144345 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr474 | phosphorylation up-regulates → | ZAP70 | 9685404 | SIGNOR-249375 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr492 | phosphorylation up-regulates → | ZAP70 | 8756661 | SIGNOR-226624 |
| DLG1 | phosphorylation up-regulates → | ZAP70 PTyr493 | phosphorylation up-regulates → | ZAP70 | 34960191 | SIGNOR-274142 |
| PTPN22 | dephosphorylation down-regulates ⊣ | ZAP70 PTyr493 | dephosphorylation up-regulates → | ZAP70 | 16461343 | SIGNOR-248838 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-247048 |
| FYN | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-279043 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-251393 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-43324 |
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254733 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-247053 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-247044 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-273948 |
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254734 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-139098 |
| LCK | phosphorylation → unknown | ZAP70 | SIGNOR-251396 |
| LCK | phosphorylation → unknown | ZAP70 | SIGNOR-251392 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-226628 |
| SRC | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-279126 |
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254732 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-251395 |
| MAPK14 | phosphorylation → down-regulates activity | ZAP70 | SIGNOR-277384 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-30429 |
| PTPN22 | dephosphorylation down-regulates | ZAP70 | SIGNOR-144345 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-249375 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-226624 |
| DLG1 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-274142 |
| PTPN6 | dephosphorylation down-regulates | ZAP70 | SIGNOR-70237 |
| PTPN22 | dephosphorylation → down-regulates activity | ZAP70 | SIGNOR-248838 |