Entity Details

Name LCK_Tyr319
ID P43403
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LCKZAP70Tyr319TSVYESPySDPEELKphosphorylation
up-regulates activity		10037717SIGNOR-251393
PTPRGZAP70Tyr319TSVYESPySDPEELKdephosphorylation
up-regulates activity		25624455SIGNOR-254734
LCKZAP70Tyr319TSVYESPySDPEELKphosphorylation
up-regulates activity		10202147SIGNOR-273948
ZAP70ZAP70Tyr319TSVYESPySDPEELKphosphorylation
up-regulates activity		10037717SIGNOR-247053
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LCKphosphorylation
up-regulates
→
ZAP70
PTyr319		phosphorylation
up-regulates
→		ZAP7010037717SIGNOR-251393
PTPRGdephosphorylation
down-regulates
⊣
ZAP70
PTyr319		dephosphorylation
down-regulates
⊣		ZAP7025624455SIGNOR-254734
LCKphosphorylation
up-regulates
→
ZAP70
PTyr319		phosphorylation
up-regulates
→		ZAP7010202147SIGNOR-273948
ZAP70phosphorylation
up-regulates
→
ZAP70
PTyr319		phosphorylation
up-regulates
→		ZAP7010037717SIGNOR-247053
Regulator Mechanism/Effect Target SIGNOR-ID
LCKphosphorylation
→
up-regulates activity 		ZAP70SIGNOR-251393
PTPRGdephosphorylation
→
up-regulates activity 		ZAP70SIGNOR-254734
LCKphosphorylation
→
up-regulates activity 		ZAP70SIGNOR-273948
ZAP70phosphorylation
→
up-regulates activity 		ZAP70SIGNOR-247053