| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | ZAP70 | Tyr474 | VLLVNRHyAKISDFG | phosphorylation up-regulates activity | 9685404 | SIGNOR-249375 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | ZAP70 PTyr474 | phosphorylation up-regulates → | ZAP70 | 9685404 | SIGNOR-249375 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-249375 |
