Entity Details

Name PTPN22_Tyr493
ID P43403
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LCKZAP70Tyr493LGADDSYyTARSAGKphosphorylation
up-regulates activity		7961936SIGNOR-251395
PTPN22ZAP70Tyr493LGADDSYyTARSAGKdephosphorylation
down-regulates		16461343SIGNOR-144345
DLG1ZAP70Tyr493LGADDSYyTARSAGKphosphorylation
up-regulates activity		34960191SIGNOR-274142
PTPN22ZAP70Tyr493LGADDSYyTARSAGKdephosphorylation
down-regulates activity		16461343SIGNOR-248838
ZAP70ZAP70Tyr493LGADDSYyTARSAGKphosphorylation
up-regulates activity		16049944SIGNOR-139098
LCKZAP70Tyr493LGADDSYyTARSAGKphosphorylation
up-regulates activity		8756661SIGNOR-226628
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LCKphosphorylation
up-regulates
→
ZAP70
PTyr493		phosphorylation
up-regulates
→		ZAP707961936SIGNOR-251395
PTPN22dephosphorylation
down-regulates
⊣
ZAP70
PTyr493		dephosphorylation
up-regulates
→		ZAP7016461343SIGNOR-144345
DLG1phosphorylation
up-regulates
→
ZAP70
PTyr493		phosphorylation
up-regulates
→		ZAP7034960191SIGNOR-274142
PTPN22dephosphorylation
down-regulates
⊣
ZAP70
PTyr493		dephosphorylation
up-regulates
→		ZAP7016461343SIGNOR-248838
ZAP70phosphorylation
up-regulates
→
ZAP70
PTyr493		phosphorylation
up-regulates
→		ZAP7016049944SIGNOR-139098
LCKphosphorylation
up-regulates
→
ZAP70
PTyr493		phosphorylation
up-regulates
→		ZAP708756661SIGNOR-226628
Regulator Mechanism/Effect Target SIGNOR-ID
LCKphosphorylation
→
up-regulates activity 		ZAP70SIGNOR-251395
PTPN22dephosphorylation
img/direct_inhibition.png
down-regulates 		ZAP70SIGNOR-144345
DLG1phosphorylation
→
up-regulates activity 		ZAP70SIGNOR-274142
PTPN22dephosphorylation
→
down-regulates activity 		ZAP70SIGNOR-248838
ZAP70phosphorylation
→
up-regulates activity 		ZAP70SIGNOR-139098
LCKphosphorylation
→
up-regulates activity 		ZAP70SIGNOR-226628