| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | ZAP70 | Tyr292 | DTLNSDGyTPEPARI | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254732 |
| ZAP70 | ZAP70 | Tyr292 | DTLNSDGyTPEPARI | phosphorylation up-regulates activity | 8756661 | SIGNOR-43324 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr292 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254732 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr292 | phosphorylation up-regulates → | ZAP70 | 8756661 | SIGNOR-43324 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254732 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-43324 |
