| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | ZAP70 | Tyr315 | MPMDTSVyESPYSDP | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254733 |
| ZAP70 | ZAP70 | Tyr315 | MPMDTSVyESPYSDP | phosphorylation up-regulates activity | 11828374 | SIGNOR-247048 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | ZAP70 PTyr315 | dephosphorylation down-regulates ⊣ | ZAP70 | 25624455 | SIGNOR-254733 |
| ZAP70 | phosphorylation up-regulates → | ZAP70 PTyr315 | phosphorylation up-regulates → | ZAP70 | 11828374 | SIGNOR-247048 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → up-regulates activity | ZAP70 | SIGNOR-254733 |
| ZAP70 | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-247048 |
