Entity Details

Name MAPK9
ID P45984
Role kinase
Enzymatic Domains
Protein kinase 26-321
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK9PSEN1Ser319NSKYNAEsTERESQDphosphorylation
up-regulates
18667537SIGNOR-179676
MAPK9ATF2Thr69SVIVADQtPTPTRFLphosphorylation
up-regulates
20068231SIGNOR-163262
MAPK9CDC25CSer168SEMKYLGsPITTVPKphosphorylation
down-regulates
20220133SIGNOR-164093
MAPK9STMN1Ser38SVPEFPLsPPKKKDLphosphorylation
down-regulates
20630875SIGNOR-166698
MAPK9IRS1Ser307TRRSRTEsITATSPAphosphorylation
down-regulates
14579029SIGNOR-118881
MAPK9NFATC4Ser213ASRFGLGsPLPSPRAphosphorylation
up-regulates activity
17875713SIGNOR-280035
MAPK9NFATC4Ser217GLGSPLPsPRASPRPphosphorylation
up-regulates activity
17875713SIGNOR-280036
MAPK9NFATC3Ser163SYRESSLsPSPASSIphosphorylation
down-regulates
9374467SIGNOR-53364
MAPK9ATP2A2phosphorylation
up-regulates activity
33334123SIGNOR-279540
MAPK9RXRASer260NMGLNPSsPNDPVTNphosphorylation
down-regulates activity
16551633SIGNOR-145301
MAPK9JUNSer73VGLLKLAsPELERLIphosphorylation
up-regulates
12040039SIGNOR-88212
MAPK9STAT3Ser727NTIDLPMsPRTLDSLphosphorylation
up-regulates
18691976SIGNOR-179275
MAPK9BCL2L11Ser69GPLAPPAsPGPFATRphosphorylation
down-regulates quantity by destabilization
18174237SIGNOR-250136
MAPK9ELK3phosphorylation
down-regulates activity
11042694SIGNOR-250138
MAPK9EGLN2Ser162SSGSGEAsAGLMEEAphosphorylation
up-regulates activity
27263528SIGNOR-279077
MAPK9KLF13Ser119GAAAAPPsPAWSEPEphosphorylation
down-regulates quantity by destabilization
37029927SIGNOR-277796
MAPK9BIDThr59EGYDELQtDGNRSSHphosphorylation
up-regulates activity
25077544SIGNOR-279220
MAPK9SRCphosphorylation
up-regulates activity
25377781SIGNOR-279222
MAPK9SH3BP5Ser351PGSLDLPsPVSLSEFphosphorylation
unknown
15158451SIGNOR-250142
MAPK9NFATC3Ser165RESSLSPsPASSISSphosphorylation
down-regulates
9374467SIGNOR-53368
MAPK9TOB1Ser154SSVSSSPsPPFGHSAphosphorylation
down-regulates
12151396SIGNOR-91071
MAPK9BCL2L11Ser59GDSCPHGsPQGPLAPphosphorylation
up-regulates activity
12818176SIGNOR-250134
MAPK9BAZ1BSer158KSDGACDsPSSDKENphosphorylation
up-regulates
19776015SIGNOR-188168
MAPK9SRCphosphorylation
up-regulates activity
25377781SIGNOR-279221
MAPK9ATF2Thr71IVADQTPtPTRFLKNphosphorylation
up-regulates
20068231SIGNOR-163266
MAPK9MAPK8IP3Thr286SVPSAAVtPLNESLQphosphorylation
up-regulates
15767678SIGNOR-134576
MAPK9TOB1Ser152PASSVSSsPSPPFGHphosphorylation
down-regulates
12151396SIGNOR-91067
MAPK9PIN1Ser115SQFSDCSsAKARGDLphosphorylation
up-regulates quantity by stabilization
34048060SIGNOR-277563
MAPK9SFNSer186FHYEIANsPEEAISLphosphorylation
down-regulates
15071501SIGNOR-124027
MAPK9CTNNB1Ser191SRHAIMRsPQMVSAIphosphorylation
up-regulates
18423204SIGNOR-178258
MAPK9BCL2L11Ser77PGPFATRsPLFIFMRphosphorylation
up-regulates activity
12818176SIGNOR-250135
MAPK9KLF13Ser123APPSPAWsEPEPEAGphosphorylation
down-regulates quantity by destabilization
37029927SIGNOR-277809
MAPK9IRS1Ser315ITATSPAsMVGGKPGphosphorylation
down-regulates
9335553SIGNOR-52696
MAPK9MAPK8IP3Thr275TTGTKSNtPTSSVPSphosphorylation
up-regulates
15767678SIGNOR-134572
MAPK9IRS1Tyr612TLHTDDGyMPMSPGVphosphorylation
down-regulates
14579029SIGNOR-118873
MAPK9MAPK8IP3Thr265GQSSAAAtPSTTGTKphosphorylation
up-regulates
15767678SIGNOR-134568
MAPK9TP53Ser6sDPSVEPPphosphorylation
up-regulates
17525747SIGNOR-155209
MAPK9CTNNB1Ser605LFVQLLYsPIENIQRphosphorylation
up-regulates
18423204SIGNOR-178262
MAPK9ATN1Ser739EEYETPEsPVPPARSphosphorylation
down-regulates activity
12812981SIGNOR-102402
MAPK9PSEN1Thr320SKYNAEStERESQDTphosphorylation
up-regulates
18667537SIGNOR-179680
MAPK9MYCSer62LLPTPPLsPSRRSGLphosphorylation
up-regulates
10551811SIGNOR-72104
MAPK9TOB1Ser164FGHSAAVsPTFMPRSphosphorylation
down-regulates
12050114SIGNOR-88748
MAPK9ELK1Ser389LSPIAPRsPAKLSFQphosphorylation
up-regulates activity
8846788SIGNOR-247062
MAPK9EGLN2Ser74TATSTTAsPLRDGFGphosphorylation
up-regulates activity
27263528SIGNOR-279078
MAPK9TP53Ser20PLSQETFsDLWKLLPphosphorylation
up-regulates
11896587SIGNOR-115835
MAPK9JUNSer63KNSDLLTsPDVGLLKphosphorylation
up-regulates
12040039SIGNOR-88208
MAPK9KLF13Ser123APPSPAWsEPEPEAGphosphorylation
down-regulates quantity by destabilization
37029927SIGNOR-277795
MAPK9JUNSer63KNSDLLTsPDVGLLKphosphorylation
up-regulates
19118012SIGNOR-183017
MAPK9IRS1Tyr632GRKGSGDyMPMSPKSphosphorylation
down-regulates
14579029SIGNOR-118877
MAPK9MFN2Ser27HMAEVNAsPLKHFVTphosphorylation
down-regulates
22748923SIGNOR-198054
MAPK9NFATC2phosphorylation
down-regulates
14517246SIGNOR-118223
MAPK9MAPK8IP1Thr103LIDATGDtPGAEDDEphosphorylation
up-regulates activity
12756254SIGNOR-101201
MAPK9ATF2Thr71IVADQTPtPTRFLKNphosphorylation
up-regulates
7737130SIGNOR-32433
MAPK9KLF13Ser119GAAAAPPsPAWSEPEphosphorylation
down-regulates quantity by destabilization
37029927SIGNOR-277810
MAPK9PPM1JSer93HAGRAVQsPPDTGRRphosphorylation
down-regulates
18553930SIGNOR-178934
MAPK9MYCSer71SRRSGLCsPSYVAVTphosphorylation
up-regulates
10551811SIGNOR-72108
MAPK9RRN3Thr200IARYVPStPWFLMPIphosphorylation
down-regulates
15805466SIGNOR-134878
MAPK9H2AXSer140GKKATQAsQEYphosphorylation
up-regulates
18158901SIGNOR-160210
MAPK9ATF2Thr69SVIVADQtPTPTRFLphosphorylation
up-regulates
7737130SIGNOR-32429
MAPK9TOB1Ser154SSVSSSPsPPFGHSAphosphorylation
down-regulates
12050114SIGNOR-88744
MAPK9TOB1Ser164FGHSAAVsPTFMPRSphosphorylation
down-regulates
12151396SIGNOR-91075
MAPK9YWHAZSer184FYYEILNsPEKACSLphosphorylation
down-regulates
15071501SIGNOR-124031
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK9phosphorylation
up-regulates
PSEN1
PSer319
phosphorylation
up-regulates
PSEN118667537SIGNOR-179676
MAPK9phosphorylation
up-regulates
ATF2
PThr69
phosphorylation
up-regulates
ATF220068231SIGNOR-163262
MAPK9phosphorylation
up-regulates
CDC25C
PSer168
phosphorylation
down-regulates
CDC25C20220133SIGNOR-164093
MAPK9phosphorylation
up-regulates
STMN1
PSer38
phosphorylation
down-regulates
STMN120630875SIGNOR-166698
MAPK9phosphorylation
up-regulates
IRS1
PSer307
phosphorylation
down-regulates
IRS114579029SIGNOR-118881
MAPK9phosphorylation
up-regulates
NFATC4
PSer213
phosphorylation
up-regulates
NFATC417875713SIGNOR-280035
MAPK9phosphorylation
up-regulates
NFATC4
PSer217
phosphorylation
up-regulates
NFATC417875713SIGNOR-280036
MAPK9phosphorylation
up-regulates
NFATC3
PSer163
phosphorylation
down-regulates
NFATC39374467SIGNOR-53364
MAPK9phosphorylation
up-regulates
RXRA
PSer260
phosphorylation
down-regulates
RXRA16551633SIGNOR-145301
MAPK9phosphorylation
up-regulates
JUN
PSer73
phosphorylation
up-regulates
JUN12040039SIGNOR-88212
MAPK9phosphorylation
up-regulates
STAT3
PSer727
phosphorylation
up-regulates
STAT318691976SIGNOR-179275
MAPK9phosphorylation
up-regulates
BCL2L11
PSer69
phosphorylation
down-regulates
BCL2L1118174237SIGNOR-250136
MAPK9phosphorylation
up-regulates
EGLN2
PSer162
phosphorylation
up-regulates
EGLN227263528SIGNOR-279077
MAPK9phosphorylation
up-regulates
KLF13
PSer119
phosphorylation
down-regulates
KLF1337029927SIGNOR-277796
MAPK9phosphorylation
up-regulates
BID
PThr59
phosphorylation
up-regulates
BID25077544SIGNOR-279220
MAPK9phosphorylation
up-regulates
SH3BP5
PSer351
phosphorylation
down-regulates
SH3BP515158451SIGNOR-250142
MAPK9phosphorylation
up-regulates
NFATC3
PSer165
phosphorylation
down-regulates
NFATC39374467SIGNOR-53368
MAPK9phosphorylation
up-regulates
TOB1
PSer154
phosphorylation
down-regulates
TOB112151396SIGNOR-91071
MAPK9phosphorylation
up-regulates
BCL2L11
PSer59
phosphorylation
up-regulates
BCL2L1112818176SIGNOR-250134
MAPK9phosphorylation
up-regulates
BAZ1B
PSer158
phosphorylation
up-regulates
BAZ1B19776015SIGNOR-188168
MAPK9phosphorylation
up-regulates
ATF2
PThr71
phosphorylation
up-regulates
ATF220068231SIGNOR-163266
MAPK9phosphorylation
up-regulates
MAPK8IP3
PThr286
phosphorylation
up-regulates
MAPK8IP315767678SIGNOR-134576
MAPK9phosphorylation
up-regulates
TOB1
PSer152
phosphorylation
down-regulates
TOB112151396SIGNOR-91067
MAPK9phosphorylation
up-regulates
PIN1
PSer115
phosphorylation
up-regulates
PIN134048060SIGNOR-277563
MAPK9phosphorylation
up-regulates
SFN
PSer186
phosphorylation
down-regulates
SFN15071501SIGNOR-124027
MAPK9phosphorylation
up-regulates
CTNNB1
PSer191
phosphorylation
up-regulates
CTNNB118423204SIGNOR-178258
MAPK9phosphorylation
up-regulates
BCL2L11
PSer77
phosphorylation
up-regulates
BCL2L1112818176SIGNOR-250135
MAPK9phosphorylation
up-regulates
KLF13
PSer123
phosphorylation
down-regulates
KLF1337029927SIGNOR-277809
MAPK9phosphorylation
up-regulates
IRS1
PSer315
phosphorylation
down-regulates
IRS19335553SIGNOR-52696
MAPK9phosphorylation
up-regulates
MAPK8IP3
PThr275
phosphorylation
up-regulates
MAPK8IP315767678SIGNOR-134572
MAPK9phosphorylation
up-regulates
IRS1
PTyr612
phosphorylation
down-regulates
IRS114579029SIGNOR-118873
MAPK9phosphorylation
up-regulates
MAPK8IP3
PThr265
phosphorylation
up-regulates
MAPK8IP315767678SIGNOR-134568
MAPK9phosphorylation
up-regulates
TP53
PSer6
phosphorylation
up-regulates
TP5317525747SIGNOR-155209
MAPK9phosphorylation
up-regulates
CTNNB1
PSer605
phosphorylation
up-regulates
CTNNB118423204SIGNOR-178262
MAPK9phosphorylation
up-regulates
ATN1
PSer739
phosphorylation
down-regulates
ATN112812981SIGNOR-102402
MAPK9phosphorylation
up-regulates
PSEN1
PThr320
phosphorylation
up-regulates
PSEN118667537SIGNOR-179680
MAPK9phosphorylation
up-regulates
MYC
PSer62
phosphorylation
up-regulates
MYC10551811SIGNOR-72104
MAPK9phosphorylation
up-regulates
TOB1
PSer164
phosphorylation
down-regulates
TOB112050114SIGNOR-88748
MAPK9phosphorylation
up-regulates
ELK1
PSer389
phosphorylation
up-regulates
ELK18846788SIGNOR-247062
MAPK9phosphorylation
up-regulates
EGLN2
PSer74
phosphorylation
up-regulates
EGLN227263528SIGNOR-279078
MAPK9phosphorylation
up-regulates
TP53
PSer20
phosphorylation
up-regulates
TP5311896587SIGNOR-115835
MAPK9phosphorylation
up-regulates
JUN
PSer63
phosphorylation
up-regulates
JUN12040039SIGNOR-88208
MAPK9phosphorylation
up-regulates
KLF13
PSer123
phosphorylation
down-regulates
KLF1337029927SIGNOR-277795
MAPK9phosphorylation
up-regulates
JUN
PSer63
phosphorylation
up-regulates
JUN19118012SIGNOR-183017
MAPK9phosphorylation
up-regulates
IRS1
PTyr632
phosphorylation
down-regulates
IRS114579029SIGNOR-118877
MAPK9phosphorylation
up-regulates
MFN2
PSer27
phosphorylation
down-regulates
MFN222748923SIGNOR-198054
MAPK9phosphorylation
up-regulates
MAPK8IP1
PThr103
phosphorylation
up-regulates
MAPK8IP112756254SIGNOR-101201
MAPK9phosphorylation
up-regulates
ATF2
PThr71
phosphorylation
up-regulates
ATF27737130SIGNOR-32433
MAPK9phosphorylation
up-regulates
KLF13
PSer119
phosphorylation
down-regulates
KLF1337029927SIGNOR-277810
MAPK9phosphorylation
up-regulates
PPM1J
PSer93
phosphorylation
down-regulates
PPM1J18553930SIGNOR-178934
MAPK9phosphorylation
up-regulates
MYC
PSer71
phosphorylation
up-regulates
MYC10551811SIGNOR-72108
MAPK9phosphorylation
up-regulates
RRN3
PThr200
phosphorylation
down-regulates
RRN315805466SIGNOR-134878
MAPK9phosphorylation
up-regulates
H2AX
PSer140
phosphorylation
up-regulates
H2AX18158901SIGNOR-160210
MAPK9phosphorylation
up-regulates
ATF2
PThr69
phosphorylation
up-regulates
ATF27737130SIGNOR-32429
MAPK9phosphorylation
up-regulates
TOB1
PSer154
phosphorylation
down-regulates
TOB112050114SIGNOR-88744
MAPK9phosphorylation
up-regulates
TOB1
PSer164
phosphorylation
down-regulates
TOB112151396SIGNOR-91075
MAPK9phosphorylation
up-regulates
YWHAZ
PSer184
phosphorylation
down-regulates
YWHAZ15071501SIGNOR-124031
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK9phosphorylation

up-regulates
PSEN1SIGNOR-179676
MAPK9phosphorylation

up-regulates
ATF2SIGNOR-163262
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
CDC25CSIGNOR-164093
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
STMN1SIGNOR-166698
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
IRS1SIGNOR-118881
MAPK9phosphorylation

up-regulates activity
NFATC4SIGNOR-280035
MAPK9phosphorylation

up-regulates activity
NFATC4SIGNOR-280036
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
NFATC3SIGNOR-53364
MAPK9phosphorylation

up-regulates activity
ATP2A2SIGNOR-279540
MAPK9phosphorylation

down-regulates activity
RXRASIGNOR-145301
MAPK9phosphorylation

up-regulates
JUNSIGNOR-88212
MAPK9phosphorylation

up-regulates
STAT3SIGNOR-179275
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
BCL2L11SIGNOR-250136
MAPK9phosphorylation

down-regulates activity
ELK3SIGNOR-250138
MAPK9phosphorylation

up-regulates activity
EGLN2SIGNOR-279077
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
KLF13SIGNOR-277796
MAPK9phosphorylation

up-regulates activity
BIDSIGNOR-279220
MAPK9phosphorylation

up-regulates activity
SRCSIGNOR-279222
MAPK9phosphorylation

unknown
SH3BP5SIGNOR-250142
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
NFATC3SIGNOR-53368
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
TOB1SIGNOR-91071
MAPK9phosphorylation

up-regulates activity
BCL2L11SIGNOR-250134
MAPK9phosphorylation

up-regulates
BAZ1BSIGNOR-188168
MAPK9phosphorylation

up-regulates activity
SRCSIGNOR-279221
MAPK9phosphorylation

up-regulates
ATF2SIGNOR-163266
MAPK9phosphorylation

up-regulates
MAPK8IP3SIGNOR-134576
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
TOB1SIGNOR-91067
MAPK9phosphorylation

up-regulates quantity by stabilization
PIN1SIGNOR-277563
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
SFNSIGNOR-124027
MAPK9phosphorylation

up-regulates
CTNNB1SIGNOR-178258
MAPK9phosphorylation

up-regulates activity
BCL2L11SIGNOR-250135
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
KLF13SIGNOR-277809
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
IRS1SIGNOR-52696
MAPK9phosphorylation

up-regulates
MAPK8IP3SIGNOR-134572
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
IRS1SIGNOR-118873
MAPK9phosphorylation

up-regulates
MAPK8IP3SIGNOR-134568
MAPK9phosphorylation

up-regulates
TP53SIGNOR-155209
MAPK9phosphorylation

up-regulates
CTNNB1SIGNOR-178262
MAPK9phosphorylation

down-regulates activity
ATN1SIGNOR-102402
MAPK9phosphorylation

up-regulates
PSEN1SIGNOR-179680
MAPK9phosphorylation

up-regulates
MYCSIGNOR-72104
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
TOB1SIGNOR-88748
MAPK9phosphorylation

up-regulates activity
ELK1SIGNOR-247062
MAPK9phosphorylation

up-regulates activity
EGLN2SIGNOR-279078
MAPK9phosphorylation

up-regulates
TP53SIGNOR-115835
MAPK9phosphorylation

up-regulates
JUNSIGNOR-88208
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
KLF13SIGNOR-277795
MAPK9phosphorylation

up-regulates
JUNSIGNOR-183017
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
IRS1SIGNOR-118877
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
MFN2SIGNOR-198054
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
NFATC2SIGNOR-118223
MAPK9phosphorylation

up-regulates activity
MAPK8IP1SIGNOR-101201
MAPK9phosphorylation

up-regulates
ATF2SIGNOR-32433
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
KLF13SIGNOR-277810
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
PPM1JSIGNOR-178934
MAPK9phosphorylation

up-regulates
MYCSIGNOR-72108
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
RRN3SIGNOR-134878
MAPK9phosphorylation

up-regulates
H2AXSIGNOR-160210
MAPK9phosphorylation

up-regulates
ATF2SIGNOR-32429
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
TOB1SIGNOR-88744
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
TOB1SIGNOR-91075
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates
YWHAZSIGNOR-124031