Summary

Name MAPK9
Full Name Mitogen-activated protein kinase 9
Synonyms MAP kinase 9, MAPK 9, JNK-55, Stress-activated protein kinase 1a, SAPK1a, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2 | JNK2, PRKM9, SAPK1A
Primary ID P45984
Links - -
Type protein
Relations 76
Inhibitors anthra[1,9-cd]pyrazol-6(2H)-one; 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-2-thiazolyl)thio]-1H-1,2,4-triazol-5-one
Function Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation H2AFX 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TOB1 0.2
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BAZ1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization NFATC3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDC25C 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YWHAZ 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SFN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.34
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MFN2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H3F3A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ up-regulates img/direct-activation.png phosphorylation PSEN1 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SH3BP5 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ELK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK9 0.48
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation MAPK9 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCL2L11 0.14
Publications: 3
+ up-regulates img/direct-activation.png phosphorylation MYC 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.51
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ATN1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation PPM1J 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK8IP1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK9 0.48
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RRN3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK8IP3 0.22
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.46
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK9 0.4
Publications: 1 Organism: Homo Sapiens
Tissue: Breast, Prostate Gland
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding MAPK9 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding JUN 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK9 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK9 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK9 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding JUNB 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ELK3 0.14
Publications: 1
+ up-regulates img/indirect-activation.png BAX 0.14
Publications: 1 Organism: Homo Sapiens