| Name | MAP2K4 |
| ID | P45985 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 102-367 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K4 | MAPK13 | Thr180 | RHADAEMtGYVVTRW | phosphorylation up-regulates activity | 10066767 | SIGNOR-273956 |
| MAP2K4 | MAPK13 | Tyr182 | ADAEMTGyVVTRWYR | phosphorylation up-regulates activity | 10066767 | SIGNOR-273955 |
| MAP2K4 | JUN | – | phosphorylation up-regulates activity | 10527909 | SIGNOR-279063 | |
| MAP2K4 | RXRA | Tyr249 | VEPKTETyVEANMGL | phosphorylation down-regulates | 10938283 | SIGNOR-80619 |
| MAP2K4 | MAPK8 | Tyr185 | TSFMMTPyVVTRYYR | phosphorylation up-regulates activity | 11062067 | SIGNOR-251419 |
| MAP2K4 | MAPK8 | Thr183 | AGTSFMMtPYVVTRY | phosphorylation up-regulates activity | 9724739 | SIGNOR-244982 |
| MAP2K4 | MAPK8 | Tyr185 | TSFMMTPyVVTRYYR | phosphorylation up-regulates activity | 9724739 | SIGNOR-249654 |
| MAP2K4 | MAPK9 | Thr183 | ACTNFMMtPYVVTRY | phosphorylation up-regulates | 17761173 | SIGNOR-260615 |
| MAP2K4 | MAPK9 | Tyr185 | TNFMMTPyVVTRYYR | phosphorylation up-regulates | 22730327 | SIGNOR-197998 |
| MAP2K4 | MAP2K4 | Ser257 | ISGQLVDsIAKTRDA | phosphorylation up-regulates activity | 9162092 | SIGNOR-251420 |
| MAP2K4 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 9162092 | SIGNOR-251421 |
| MAP2K4 | MAPK10 | – | phosphorylation up-regulates | 10715136 | SIGNOR-75792 | |
| MAP2K4 | MAPK10 | – | phosphorylation up-regulates | 11062067 | SIGNOR-83721 | |
| MAP2K4 | MAPK10 | – | phosphorylation up-regulates | 11242034 | SIGNOR-105692 | |
| MAP2K4 | MAPK10 | Tyr223 | TSFMMTPyVVTRYYR | phosphorylation up-regulates | 15911620 | SIGNOR-137605 |
| MAP2K4 | MAPK10 | Thr221 | AGTSFMMtPYVVTRY | phosphorylation up-regulates | 17761173 | SIGNOR-260614 |
| MAP2K4 | MAPK10 | – | phosphorylation up-regulates | 8974401 | SIGNOR-45360 | |
| MAP2K4 | MAPK10 | Tyr223 | TSFMMTPyVVTRYYR | phosphorylation up-regulates activity | 10715136 | SIGNOR-251423 |
| MAP2K4 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 7535770 | SIGNOR-27973 |
| MAP2K4 | MAPK14 | – | phosphorylation up-regulates activity | 7839144 | SIGNOR-34121 | |
| MAP2K4 | JNK | – | phosphorylation up-regulates activity | 11062067 | SIGNOR-83729 | |
| MAP2K4 | JNK | – | phosphorylation up-regulates activity | 21561061 | SIGNOR-260759 | |
| MAP2K4 | JNK | – | phosphorylation up-regulates activity | 8974401 | SIGNOR-236110 | |
| MAP2K4 | p38 | – | phosphorylation up-regulates activity | 7839144 | SIGNOR-260722 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K4 | phosphorylation up-regulates → | MAPK13 PThr180 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273956 |
| MAP2K4 | phosphorylation up-regulates → | MAPK13 PTyr182 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273955 |
| MAP2K4 | phosphorylation up-regulates → | RXRA PTyr249 | phosphorylation down-regulates ⊣ | RXRA | 10938283 | SIGNOR-80619 |
| MAP2K4 | phosphorylation up-regulates → | MAPK8 PTyr185 | phosphorylation up-regulates → | MAPK8 | 11062067 | SIGNOR-251419 |
| MAP2K4 | phosphorylation up-regulates → | MAPK8 PThr183 | phosphorylation up-regulates → | MAPK8 | 9724739 | SIGNOR-244982 |
| MAP2K4 | phosphorylation up-regulates → | MAPK8 PTyr185 | phosphorylation up-regulates → | MAPK8 | 9724739 | SIGNOR-249654 |
| MAP2K4 | phosphorylation up-regulates → | MAPK9 PThr183 | phosphorylation up-regulates → | MAPK9 | 17761173 | SIGNOR-260615 |
| MAP2K4 | phosphorylation up-regulates → | MAPK9 PTyr185 | phosphorylation up-regulates → | MAPK9 | 22730327 | SIGNOR-197998 |
| MAP2K4 | phosphorylation up-regulates → | MAP2K4 PSer257 | phosphorylation up-regulates → | MAP2K4 | 9162092 | SIGNOR-251420 |
| MAP2K4 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 9162092 | SIGNOR-251421 |
| MAP2K4 | phosphorylation up-regulates → | MAPK10 PTyr223 | phosphorylation up-regulates → | MAPK10 | 15911620 | SIGNOR-137605 |
| MAP2K4 | phosphorylation up-regulates → | MAPK10 PThr221 | phosphorylation up-regulates → | MAPK10 | 17761173 | SIGNOR-260614 |
| MAP2K4 | phosphorylation up-regulates → | MAPK10 PTyr223 | phosphorylation up-regulates → | MAPK10 | 10715136 | SIGNOR-251423 |
| MAP2K4 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-27973 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K4 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273956 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273955 |
| MAP2K4 | phosphorylation → up-regulates activity | JUN | SIGNOR-279063 |
| MAP2K4 | phosphorylation down-regulates | RXRA | SIGNOR-80619 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-251419 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-244982 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-249654 |
| MAP2K4 | phosphorylation → up-regulates | MAPK9 | SIGNOR-260615 |
| MAP2K4 | phosphorylation → up-regulates | MAPK9 | SIGNOR-197998 |
| MAP2K4 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-251420 |
| MAP2K4 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-251421 |
| MAP2K4 | phosphorylation → up-regulates | MAPK10 | SIGNOR-75792 |
| MAP2K4 | phosphorylation → up-regulates | MAPK10 | SIGNOR-83721 |
| MAP2K4 | phosphorylation → up-regulates | MAPK10 | SIGNOR-105692 |
| MAP2K4 | phosphorylation → up-regulates | MAPK10 | SIGNOR-137605 |
| MAP2K4 | phosphorylation → up-regulates | MAPK10 | SIGNOR-260614 |
| MAP2K4 | phosphorylation → up-regulates | MAPK10 | SIGNOR-45360 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK10 | SIGNOR-251423 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-27973 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-34121 |
| MAP2K4 | phosphorylation → up-regulates activity | JNK | SIGNOR-83729 |
| MAP2K4 | phosphorylation → up-regulates activity | JNK | SIGNOR-260759 |
| MAP2K4 | phosphorylation → up-regulates activity | JNK | SIGNOR-236110 |
| MAP2K4 | phosphorylation → up-regulates activity | p38 | SIGNOR-260722 |