+ |
MAP2K4 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251420 |
Ser257 |
ISGQLVDsIAKTRDA |
in vitro |
|
pmid |
sentence |
9162092 |
Ser221 and, to a lesser extent, Thr225 in MKK4 as necessary sites for basal and MEKK-induced autophosphorylation and activation of MKK4. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251421 |
Thr261 |
LVDSIAKtRDAGCRP |
in vitro |
|
pmid |
sentence |
9162092 |
Ser221 and, to a lesser extent, Thr225 in MKK4 as necessary sites for basal and MEKK-induced autophosphorylation and activation of MKK4. |
|
Publications: |
2 |
Organism: |
In Vitro |
Pathways: | COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV ATTACHMENT AND ENTRY, TNF-alpha Signaling, TGF-beta Signaling |
+ |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.605 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-48574 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
COS-1 Cell |
pmid |
sentence |
9003778 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP3K11 | up-regulates
phosphorylation
|
MAP2K4 |
0.605 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-128420 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
|
pmid |
sentence |
15328343 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-75836 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
pmid |
sentence |
10727406 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
AKT | down-regulates
phosphorylation
|
MAP2K4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-244285 |
Ser80 |
IERLRTHsIESSGKL |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
11707464 |
Akt phosphorylated sek1 on serine 78. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, EGFR Signaling |
+ |
AKT1 | down-regulates
phosphorylation
|
MAP2K4 |
0.577 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-236494 |
Ser80 |
IERLRTHsIESSGKL |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
11707464 |
Akt phosphorylated sek1 on serine 78. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | P38 Signaling and Myogenesis |
+ |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK13 |
0.432 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273956 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273955 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK14 |
0.57 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-27973 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
pmid |
sentence |
7535770 |
Recently, two MAP kinase kinases (MKK3 and MKK4) that activate p38 MAP kinase have been identified. The mechanism of p38 activation is mediated by dual phosphorylation on Thr-180 and Tyr-182 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-34121 |
|
|
Homo sapiens |
|
pmid |
sentence |
7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling |
+ |
MAP2K4 | up-regulates
phosphorylation
|
MAPK9 |
0.712 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260615 |
Thr183 |
ACTNFMMtPYVVTRY |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17761173 |
We next examined whether the phosphorylation of JNK at threonine 183 (Thr183) and tyrosine 185 (Tyr185) was enhanced by GRASP‐1 expression. Phosphorylation of Thr183 and Tyr185 by SEK1/MKK4, which is in turn phosphorylated and activated by several kinases including MEKK1, is known to activate JNK1/2/3 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-197998 |
Tyr185 |
TNFMMTPyVVTRYYR |
Homo sapiens |
|
pmid |
sentence |
22730327 |
Mkk4, which activates p38gamma, p38delta, and jnk2 to phosphorylate p53 on ser-33 and cause a transient g(1) arrest. A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1) |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Tissue: |
Breast, Prostate Gland |
+ |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK8 |
0.736 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-244982 |
Thr183 |
AGTSFMMtPYVVTRY |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
9724739 |
MKK4/7, in turn, phosphorylates JNK on residues 183 and 185 (1720). Activated JNK phosphorylates its substrates, c-Jun, ATF2, ELK1, and p53 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251419 |
Tyr185 |
TSFMMTPyVVTRYYR |
in vitro |
|
pmid |
sentence |
11062067 |
Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7. Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183) in three SAPK1/JNK1 isoforms tested (JNK1 alpha 1, JNK2 alpha 2 and JNK3 alpha 1). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249654 |
Tyr185 |
TSFMMTPyVVTRYYR |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
9724739 |
MKK4/7, in turn, phosphorylates JNK on residues 183 and 185 (1720). Activated JNK phosphorylates its substrates, c-Jun, ATF2, ELK1, and p53 |
|
Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
Pathways: | COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, SAPK/JNK Signaling, SARS-CoV ATTACHMENT AND ENTRY, TNF-alpha Signaling |
+ |
MAP2K4 | up-regulates
phosphorylation
|
MAPK10 |
0.728 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260614 |
Thr221 |
AGTSFMMtPYVVTRY |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17761173 |
We next examined whether the phosphorylation of JNK at threonine 183 (Thr183) and tyrosine 185 (Tyr185) was enhanced by GRASP‐1 expression. Phosphorylation of Thr183 and Tyr185 by SEK1/MKK4, which is in turn phosphorylated and activated by several kinases including MEKK1, is known to activate JNK1/2/3 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-137605 |
Tyr223 |
TSFMMTPyVVTRYYR |
Homo sapiens |
|
pmid |
sentence |
15911620 |
Two mapkks, sek1 and mkk7, synergistically activate jnk. Sek1 prefers the tyr-185 residue, and mkk7 prefers the thr-183 residue (17, 19). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-75792 |
|
|
Homo sapiens |
|
pmid |
sentence |
10715136 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subs of map kinases, respectively. Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-83721 |
|
|
Homo sapiens |
|
pmid |
sentence |
11062067 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subs of map kinases, respectively. Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-45360 |
|
|
Homo sapiens |
|
pmid |
sentence |
8974401 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subgroups of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subgroups of map kinases, respectively. here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-105692 |
|
|
Homo sapiens |
|
pmid |
sentence |
11242034 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subs of map kinases, respectively. Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
Publications: |
6 |
Organism: |
Homo Sapiens |
+ |
MAP3K1 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.712 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-236380 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
pmid |
sentence |
9712898 |
The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, sek1 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-236376 |
|
|
Homo sapiens |
|
pmid |
sentence |
9712898 |
The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, SEK1 |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TNF-alpha Signaling |
+ |
MAP3K5 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.612 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-45373 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
pmid |
sentence |
8974401 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-45366 |
|
|
Homo sapiens |
COS-7 Cell |
pmid |
sentence |
8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling |
+ |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK10 |
0.728 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251423 |
Tyr223 |
TSFMMTPyVVTRYYR |
in vitro |
|
pmid |
sentence |
10715136 |
Activation of JNK3 alpha 1 requires both MKK4 and MKK7. both MKK4 and MKK7 were required for bisphosphorylation and maximal enzyme activity. a processive mechanism for JNK3R1 activation that requires phosphorylation of Thr 221 by MKK7 prior to phosphorylation of Tyr 223 by MKK4 |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
MAP2K4 | down-regulates
phosphorylation
|
RXRA |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-80619 |
Tyr249 |
VEPKTETyVEANMGL |
Homo sapiens |
|
pmid |
sentence |
10938283 |
Phosphorylation by mkk4/sek1 had profound effects on the biochemical properties of rxr, inhibiting the expression of genes activated by rxr-retinoic acid receptor complexes. Tyr-249 in the rxr de region was required for the inhibitory effect of mkk4/sek1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FLNA | up-regulates activity
binding
|
MAP2K4 |
0.503 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260629 |
|
|
Homo sapiens |
|
pmid |
sentence |
20156194 |
We used Filamin-A-deficient cells to show that Filamin A enhances MKK7 activation and is important for synergistic stress-induced JNK activation in vivo. Thus Filamin A is a novel member of the group of scaffold proteins whose function is to link two MAPKKs together and promote JNK activation. The present study provides evidence that Filamin A is one of the ‘binder’ molecules presumed to directly and closely connect MKK4 and MKK7 so that they can mediate this tyrosine/threonine phosphorylation. We showed that Filamin A (as well as Filamin B and C) associate with MKK7 and MKK4, but not with JNK1 itself |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
+ |
MAP3K4 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.545 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-62369 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
9841871 |
When truncated mapkkk4 (deltamapkkk4) was overexpressed in hek293 cells, it was constitutively activeco-expressed map kinase kinase (mkk)-1, mkk-4, mkk-3 and mkk-6 were activated in vivo by deltamapkkk4. All of the above mkks purified from escherichia coli were phosphorylated and activated by deltamapkkk4 immunoprecipitates in vitro. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | P38 Signaling |
+ |
MAPK8IP3 | up-regulates
binding
|
MAP2K4 |
0.615 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-71468 |
|
|
Homo sapiens |
|
pmid |
sentence |
10523642 |
Overexpression of full-length jsap1 in cos-7 cells led to a considerable enhancement of jnk3 activation, and modest enhancement of jnk1 and jnk2 activation, by the mekk1-sek1 pathwaythe regions of jsap1 that bound jnk, sek1, and mekk1 were distinct from one another. Jnk and mekk1 also bound jsap1 in vitro, suggesting that these interactions are direct. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP3K8 | up-regulates
phosphorylation
|
MAP2K4 |
0.535 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-196744 |
|
|
Homo sapiens |
|
pmid |
sentence |
22435554 |
Furthermore, we found that immunoprecipitated tpl-2 could directly phosphorylate and activate both mek-1 and mkk4 (also known as sek-1) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP2K4 | up-regulates activity
phosphorylation
|
JNK |
0.736 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-83729 |
|
|
Homo sapiens |
|
pmid |
sentence |
11062067 |
Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-236110 |
|
|
Homo sapiens |
COS-7 Cell |
pmid |
sentence |
8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260759 |
|
|
Homo sapiens |
HuH-7 Cell |
pmid |
sentence |
21561061 |
Activation of JNK pathway components in 3b-expressing cells was assessed by analyzing levels of active phosphorylated formsof JNK and its upstream kinase MEK4. An enhanced phosphor-ylation of JNK and MEK4 was observed in cells expressing 3b ascompared to control cells expressing GFP |
|
Publications: |
3 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |
+ |
MAP3K3 | up-regulates activity
binding
|
MAP2K4 |
0.581 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-48628 |
|
|
Homo sapiens |
COS-7 Cell |
pmid |
sentence |
9162092 |
These data indicate that mkk3 is preferentially activated by mekk3, whereas mkk4 is activated both by mekk2 and mekk3. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
WDR62 | up-regulates activity
relocalization
|
MAP2K4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271715 |
|
|
Mus musculus |
|
pmid |
sentence |
30566428 |
In the WT brain, the WDR62 scaffold organizes a protein complex including MEKK3, MKK4/7, and JNK1 to control NPC development during corticogenesis |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
3b | up-regulates activity
|
MAP2K4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260761 |
|
|
Homo sapiens |
|
pmid |
sentence |
21561061 |
An enhanced phosphorylation of JNK and MEK4 was observed in cells expressing 3b ascompared to control cells expressing GFP |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, SARS-CoV ATTACHMENT AND ENTRY |
+ |
MAP2K4 | up-regulates activity
phosphorylation
|
p38 |
0.57 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260722 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
+ |
TAOK2 | up-regulates activity
binding
|
MAP2K4 |
0.264 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-74864 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
pmid |
sentence |
10660600 |
Immunoprecipitated psk phosphorylates myelin basic protein and transfected psk stimulates mkk4 and mkk7 and activates the c-jun n-terminal kinase mitogen-activated protein kinase pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | P38 Signaling |
+ |
MAP3K20 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-243348 |
|
|
Homo sapiens |
|
pmid |
sentence |
11416147 |
We show here that members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are expressed in neuronal cells and are likely to act between Rac1/Cdc42 and MKK4 and -7 in death signaling. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FLNA | up-regulates
binding
|
MAP2K4 |
0.503 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-45887 |
|
|
Homo sapiens |
Melanoma Cell |
pmid |
sentence |
9006895 |
Sek-1 binds directly and specifically to the actin-binding protein abp-280. As a consequence, active sek-1 is capable of phosphorylating and activating in vitro added bacterial recombinant sapk. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
+ |
MAP3K2 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.589 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-107695 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
11343802 |
Both mekk2 and mekk3 are able to activate the jun kinase pathway in vivo. However, following routine immunoprecipitation in triton x-100, mekk2 but not mekk3 is able to effectively phosphorylate both sek-1 and mek-1 and to undergo autophosphorylation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SH3RF1 | up-regulates
binding
|
MAP2K4 |
0.319 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-96952 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
12514131 |
We confirmed that posh binds activated rac1 and find that it also binds all mlk family members tested and interacts with mkk4/7 as well as jnk1 and jnk2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | SAPK/JNK Signaling |
+ |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.692 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-50618 |
|
|
Homo sapiens |
|
pmid |
sentence |
9278437 |
Mitogen-activated protein kinase kinase 4 (mkk4)/stress-activated protein kinase/extracellular signal-regulated kinase (sek1), a dual-specificity kinase that phosphorylates and activates jnk, synergized with tak1 in activating jnk.Taken together, these results identify TAK1 as a regulator in the HPK1 --> TAK1 --> MKK4/SEK1 --> JNK kinase cascade and indicate the involvement of JNK in the TGF-beta signaling pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |