| Name | MAP2K4 |
| ID | P45985 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 102-367 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K2 | MAP2K4 | – | phosphorylation up-regulates activity | 11343802 | SIGNOR-107695 | |
| MAP3K8 | MAP2K4 | – | phosphorylation up-regulates | 22435554 | SIGNOR-196744 | |
| MAP3K4 | MAP2K4 | – | phosphorylation up-regulates activity | 9841871 | SIGNOR-62369 | |
| MAP2K4 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 9162092 | SIGNOR-251421 |
| MAP3K12 | MAP2K4 | Ser257 | ISGQLVDsIAKTRDA | phosphorylation up-regulates activity | 25594179 | SIGNOR-279629 |
| MAP3K10 | MAP2K4 | – | phosphorylation up-regulates activity | 9182538 | SIGNOR-278954 | |
| MAP3K11 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates | 10727406 | SIGNOR-75836 |
| SRMS | MAP2K4 | Tyr307 | LATGRFPyPKWNSVF | phosphorylation down-regulates activity | 37020040 | SIGNOR-277902 |
| MAP3K5 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 8974401 | SIGNOR-45373 |
| AKT | MAP2K4 | Ser80 | IERLRTHsIESSGKL | phosphorylation down-regulates activity | 11707464 | SIGNOR-275980 |
| MAP3K1 | MAP2K4 | – | phosphorylation up-regulates activity | 9712898 | SIGNOR-236376 | |
| MAP3K11 | MAP2K4 | Ser257 | ISGQLVDsIAKTRDA | phosphorylation up-regulates activity | 9003778 | SIGNOR-48574 |
| MAP3K1 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 9712898 | SIGNOR-236380 |
| MAP2K4 | MAP2K4 | Ser257 | ISGQLVDsIAKTRDA | phosphorylation up-regulates activity | 9162092 | SIGNOR-251420 |
| MAP3K20 | MAP2K4 | – | phosphorylation up-regulates activity | 11416147 | SIGNOR-243348 | |
| SRMS | MAP2K4 | Tyr269 | RDAGCRPyMAPERID | phosphorylation down-regulates activity | 37020040 | SIGNOR-277903 |
| AKT | MAP2K4 | Ser80 | IERLRTHsIESSGKL | phosphorylation down-regulates | 11707464 | SIGNOR-244285 |
| MAP3K11 | MAP2K4 | Ser257 | ISGQLVDsIAKTRDA | phosphorylation up-regulates | 15328343 | SIGNOR-128420 |
| MAP3K5 | MAP2K4 | – | phosphorylation up-regulates activity | 8974401 | SIGNOR-45366 | |
| MAP3K7 | MAP2K4 | – | phosphorylation up-regulates activity | 9278437 | SIGNOR-50618 | |
| AKT1 | MAP2K4 | Ser80 | IERLRTHsIESSGKL | phosphorylation down-regulates | 11707464 | SIGNOR-236494 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K4 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 9162092 | SIGNOR-251421 |
| MAP3K12 | phosphorylation up-regulates → | MAP2K4 PSer257 | phosphorylation up-regulates → | MAP2K4 | 25594179 | SIGNOR-279629 |
| MAP3K11 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 10727406 | SIGNOR-75836 |
| SRMS | phosphorylation up-regulates → | MAP2K4 PTyr307 | phosphorylation down-regulates ⊣ | MAP2K4 | 37020040 | SIGNOR-277902 |
| MAP3K5 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 8974401 | SIGNOR-45373 |
| AKT | phosphorylation up-regulates → | MAP2K4 PSer80 | phosphorylation down-regulates ⊣ | MAP2K4 | 11707464 | SIGNOR-275980 |
| MAP3K11 | phosphorylation up-regulates → | MAP2K4 PSer257 | phosphorylation up-regulates → | MAP2K4 | 9003778 | SIGNOR-48574 |
| MAP3K1 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 9712898 | SIGNOR-236380 |
| MAP2K4 | phosphorylation up-regulates → | MAP2K4 PSer257 | phosphorylation up-regulates → | MAP2K4 | 9162092 | SIGNOR-251420 |
| SRMS | phosphorylation up-regulates → | MAP2K4 PTyr269 | phosphorylation down-regulates ⊣ | MAP2K4 | 37020040 | SIGNOR-277903 |
| AKT | phosphorylation up-regulates → | MAP2K4 PSer80 | phosphorylation down-regulates ⊣ | MAP2K4 | 11707464 | SIGNOR-244285 |
| MAP3K11 | phosphorylation up-regulates → | MAP2K4 PSer257 | phosphorylation up-regulates → | MAP2K4 | 15328343 | SIGNOR-128420 |
| AKT1 | phosphorylation up-regulates → | MAP2K4 PSer80 | phosphorylation down-regulates ⊣ | MAP2K4 | 11707464 | SIGNOR-236494 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K2 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-107695 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K4 | SIGNOR-196744 |
| MAP3K4 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-62369 |
| MAP2K4 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-251421 |
| MAP3K12 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-279629 |
| MAP3K10 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-278954 |
| MAP3K11 | phosphorylation → up-regulates | MAP2K4 | SIGNOR-75836 |
| SRMS | phosphorylation → down-regulates activity | MAP2K4 | SIGNOR-277902 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-45373 |
| AKT | phosphorylation → down-regulates activity | MAP2K4 | SIGNOR-275980 |
| MAP3K1 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-236376 |
| MAP3K11 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-48574 |
| MAP3K1 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-236380 |
| MAP2K4 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-251420 |
| MAP3K20 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-243348 |
| SRMS | phosphorylation → down-regulates activity | MAP2K4 | SIGNOR-277903 |
| AKT | phosphorylation down-regulates | MAP2K4 | SIGNOR-244285 |
| MAP3K11 | phosphorylation → up-regulates | MAP2K4 | SIGNOR-128420 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-45366 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-50618 |
| AKT1 | phosphorylation down-regulates | MAP2K4 | SIGNOR-236494 |