| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K1 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 9712898 | SIGNOR-236380 |
| MAP2K4 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 9162092 | SIGNOR-251421 |
| MAP3K11 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates | 10727406 | SIGNOR-75836 |
| MAP3K5 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 8974401 | SIGNOR-45373 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K1 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 9712898 | SIGNOR-236380 |
| MAP2K4 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 9162092 | SIGNOR-251421 |
| MAP3K11 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 10727406 | SIGNOR-75836 |
| MAP3K5 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 8974401 | SIGNOR-45373 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K1 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-236380 |
| MAP2K4 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-251421 |
| MAP3K11 | phosphorylation → up-regulates | MAP2K4 | SIGNOR-75836 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-45373 |