Entity Details

Name NSF
ID P46459
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LRRK2NSFThr645RKLLIIGtTSRKDVLphosphorylation
up-regulates activity		26758690SIGNOR-277196
CDK16NSFSer569FPFIKICsPDKMIGFphosphorylation
down-regulates activity		16461345SIGNOR-279511
PRKCENSFSer460MNRHIKAsTKVEVDMphosphorylation
up-regulates activity		20962217SIGNOR-278300
PTPN9NSFTyr83QEIEVSLyTFDKAKQdephosphorylation
down-regulates		15322554SIGNOR-128348
PRKCENSFThr461NRHIKAStKVEVDMEphosphorylation
up-regulates activity		20962217SIGNOR-278299
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LRRK2phosphorylation
up-regulates
→
NSF
PThr645		phosphorylation
up-regulates
→		NSF26758690SIGNOR-277196
CDK16phosphorylation
up-regulates
→
NSF
PSer569		phosphorylation
down-regulates
⊣		NSF16461345SIGNOR-279511
PRKCEphosphorylation
up-regulates
→
NSF
PSer460		phosphorylation
up-regulates
→		NSF20962217SIGNOR-278300
PTPN9dephosphorylation
down-regulates
⊣
NSF
PTyr83		dephosphorylation
up-regulates
→		NSF15322554SIGNOR-128348
PRKCEphosphorylation
up-regulates
→
NSF
PThr461		phosphorylation
up-regulates
→		NSF20962217SIGNOR-278299
Regulator Mechanism/Effect Target SIGNOR-ID
LRRK2phosphorylation
→
up-regulates activity 		NSFSIGNOR-277196
CDK16phosphorylation
→
down-regulates activity 		NSFSIGNOR-279511
PRKCEphosphorylation
→
up-regulates activity 		NSFSIGNOR-278300
PTPN9dephosphorylation
img/direct_inhibition.png
down-regulates 		NSFSIGNOR-128348
PRKCEphosphorylation
→
up-regulates activity 		NSFSIGNOR-278299