| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates | 17254967 | SIGNOR-152835 |
| CDK1 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 10931950 | SIGNOR-80230 |
| ERK1/2 | CDKN1B | Ser178 | EENVSDGsPNAGSVE | phosphorylation up-regulates | 10831586 | SIGNOR-244517 |
| SGK1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18570873 | SIGNOR-179121 |
| PPM1D | CDKN1B | Ser140 | PKTDPSDsQTGLAEQ | dephosphorylation down-regulates activity | 31959038 | SIGNOR-277109 |
| SGK1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18570873 | SIGNOR-179117 |
| FLT3 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 28522571 | SIGNOR-269208 |
| PIM | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18593906 | SIGNOR-259425 |
| PIM1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18593906 | SIGNOR-179296 |
| CDK6 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 16160006 | SIGNOR-140405 |
| CHUK | CDKN1B | Ser183 | DGSPNAGsVEQTPKK | phosphorylation down-regulates activity | 23602409 | SIGNOR-278438 |
| LYN | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates | 21423214 | SIGNOR-172904 |
| HIPK2 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 21715331 | SIGNOR-174617 |
| ABL1 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates quantity | 17254966 | SIGNOR-245293 |
| GSK3B | CDKN1B | Ser160 | KRPATDDsSTQNKRA | phosphorylation up-regulates quantity by stabilization | 21439087 | SIGNOR-278938 |
| GSK3B | CDKN1B | Ser161 | RPATDDSsTQNKRAN | phosphorylation up-regulates quantity by stabilization | 21439087 | SIGNOR-278939 |
| AKT1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates | 12042314 | SIGNOR-88294 |
| AKT1 | CDKN1B | – | phosphorylation down-regulates | 14967450 | SIGNOR-121944 | |
| DYRK1A | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates activity | 24806449 | SIGNOR-278250 |
| AKT2 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 12244303 | SIGNOR-93122 |
| PPM1G | CDKN1B | Thr198 | PGLRRRQt | dephosphorylation up-regulates activity | 27822412 | SIGNOR-277112 |
| RPS6KA1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation up-regulates activity | 19470470 | SIGNOR-279653 |
| SRC | CDKN1B | Tyr74 | HKPLEGKyEWQEVEK | phosphorylation down-regulates | 17254967 | SIGNOR-152831 |
| PRKAA1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation up-regulates quantity by stabilization | 30033086 | SIGNOR-259859 |
| CAMK1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation up-regulates activity | 23707388 | SIGNOR-261194 |
| MAPK1 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 10831586 | SIGNOR-77651 |
| ERK1/2 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 10831586 | SIGNOR-244622 |
| PIM1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18593906 | SIGNOR-179300 |
| AKT | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 12042314 | SIGNOR-244194 |
| AKT1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18570873 | SIGNOR-179109 |
| CyclinY/CDK16 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates quantity by destabilization | 25205104 | SIGNOR-273012 |
| DYRK1B | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 15546868 | SIGNOR-235805 |
| UHMK1 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 10831586 | SIGNOR-77705 |
| CDK2 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 17409098 | SIGNOR-154188 |
| CAMK1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation up-regulates activity | 23707388 | SIGNOR-261195 |
| SRC | CDKN1B | Tyr89 | GSLPEFYyRPPRPPK | phosphorylation down-regulates | 17254967 | SIGNOR-152839 |
| UHMK1 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 12093740 | SIGNOR-90274 |
| EPHB3 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates activity | 10389236 | SIGNOR-279406 |
| MAPK3 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 10931950 | SIGNOR-80234 |
| CDK5 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates activity | 26146988 | SIGNOR-279681 |
| CDK5 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates activity | 26146988 | SIGNOR-279680 |
| MAPK1 | CDKN1B | Ser178 | EENVSDGsPNAGSVE | phosphorylation up-regulates | 10831586 | SIGNOR-77655 |
| ATM | CDKN1B | Ser140 | PKTDPSDsQTGLAEQ | phosphorylation up-regulates quantity by stabilization | 27611996 | SIGNOR-279392 |
| JAK2 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 21423214 | SIGNOR-278260 |
| CDK16 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates quantity | 25205104 | SIGNOR-278214 |
| Gbeta | CDKN1B | – | phosphorylation down-regulates | 10931950 | SIGNOR-270087 | |
| AKT | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates activity | 18570873 | SIGNOR-244202 |
| CDK6 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 16160006 | SIGNOR-140401 |
| PTPN11 | CDKN1B | – | dephosphorylation up-regulates activity | 19066472 | SIGNOR-277168 | |
| ABL1 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 17254966 | SIGNOR-251426 |
| CDK8 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 25818643 | SIGNOR-278513 |
| CDK16 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates quantity by destabilization | 25205104 | SIGNOR-273016 |
| PIM | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18593906 | SIGNOR-259426 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 17254967 | SIGNOR-152835 |
| CDK1 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 10931950 | SIGNOR-80230 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1B PSer178 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-244517 |
| SGK1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179121 |
| PPM1D | dephosphorylation down-regulates ⊣ | CDKN1B PSer140 | dephosphorylation up-regulates → | CDKN1B | 31959038 | SIGNOR-277109 |
| SGK1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179117 |
| FLT3 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 28522571 | SIGNOR-269208 |
| PIM | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-259425 |
| PIM1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-179296 |
| CDK6 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 16160006 | SIGNOR-140405 |
| CHUK | phosphorylation up-regulates → | CDKN1B PSer183 | phosphorylation down-regulates ⊣ | CDKN1B | 23602409 | SIGNOR-278438 |
| LYN | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 21423214 | SIGNOR-172904 |
| HIPK2 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 21715331 | SIGNOR-174617 |
| ABL1 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 17254966 | SIGNOR-245293 |
| GSK3B | phosphorylation up-regulates → | CDKN1B PSer160 | phosphorylation up-regulates → | CDKN1B | 21439087 | SIGNOR-278938 |
| GSK3B | phosphorylation up-regulates → | CDKN1B PSer161 | phosphorylation up-regulates → | CDKN1B | 21439087 | SIGNOR-278939 |
| AKT1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 12042314 | SIGNOR-88294 |
| DYRK1A | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 24806449 | SIGNOR-278250 |
| AKT2 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 12244303 | SIGNOR-93122 |
| PPM1G | dephosphorylation down-regulates ⊣ | CDKN1B PThr198 | dephosphorylation down-regulates ⊣ | CDKN1B | 27822412 | SIGNOR-277112 |
| RPS6KA1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation up-regulates → | CDKN1B | 19470470 | SIGNOR-279653 |
| SRC | phosphorylation up-regulates → | CDKN1B PTyr74 | phosphorylation down-regulates ⊣ | CDKN1B | 17254967 | SIGNOR-152831 |
| PRKAA1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation up-regulates → | CDKN1B | 30033086 | SIGNOR-259859 |
| CAMK1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation up-regulates → | CDKN1B | 23707388 | SIGNOR-261194 |
| MAPK1 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-77651 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-244622 |
| PIM1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-179300 |
| AKT | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 12042314 | SIGNOR-244194 |
| AKT1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179109 |
| CyclinY/CDK16 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 25205104 | SIGNOR-273012 |
| DYRK1B | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 15546868 | SIGNOR-235805 |
| UHMK1 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-77705 |
| CDK2 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 17409098 | SIGNOR-154188 |
| CAMK1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation up-regulates → | CDKN1B | 23707388 | SIGNOR-261195 |
| SRC | phosphorylation up-regulates → | CDKN1B PTyr89 | phosphorylation down-regulates ⊣ | CDKN1B | 17254967 | SIGNOR-152839 |
| UHMK1 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 12093740 | SIGNOR-90274 |
| EPHB3 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 10389236 | SIGNOR-279406 |
| MAPK3 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 10931950 | SIGNOR-80234 |
| CDK5 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 26146988 | SIGNOR-279681 |
| CDK5 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 26146988 | SIGNOR-279680 |
| MAPK1 | phosphorylation up-regulates → | CDKN1B PSer178 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-77655 |
| ATM | phosphorylation up-regulates → | CDKN1B PSer140 | phosphorylation up-regulates → | CDKN1B | 27611996 | SIGNOR-279392 |
| JAK2 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 21423214 | SIGNOR-278260 |
| CDK16 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 25205104 | SIGNOR-278214 |
| AKT | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-244202 |
| CDK6 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 16160006 | SIGNOR-140401 |
| ABL1 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 17254966 | SIGNOR-251426 |
| CDK8 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 25818643 | SIGNOR-278513 |
| CDK16 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 25205104 | SIGNOR-273016 |
| PIM | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-259426 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation down-regulates | CDKN1B | SIGNOR-152835 |
| CDK1 | phosphorylation down-regulates | CDKN1B | SIGNOR-80230 |
| ERK1/2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-244517 |
| SGK1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-179121 |
| PPM1D | dephosphorylation → down-regulates activity | CDKN1B | SIGNOR-277109 |
| SGK1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179117 |
| FLT3 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-269208 |
| PIM | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-259425 |
| PIM1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179296 |
| CDK6 | phosphorylation down-regulates | CDKN1B | SIGNOR-140405 |
| CHUK | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-278438 |
| LYN | phosphorylation down-regulates | CDKN1B | SIGNOR-172904 |
| HIPK2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-174617 |
| ABL1 | phosphorylation → down-regulates quantity | CDKN1B | SIGNOR-245293 |
| GSK3B | phosphorylation → up-regulates quantity by stabilization | CDKN1B | SIGNOR-278938 |
| GSK3B | phosphorylation → up-regulates quantity by stabilization | CDKN1B | SIGNOR-278939 |
| AKT1 | phosphorylation down-regulates | CDKN1B | SIGNOR-88294 |
| AKT1 | phosphorylation down-regulates | CDKN1B | SIGNOR-121944 |
| DYRK1A | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-278250 |
| AKT2 | phosphorylation down-regulates | CDKN1B | SIGNOR-93122 |
| PPM1G | dephosphorylation → up-regulates activity | CDKN1B | SIGNOR-277112 |
| RPS6KA1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-279653 |
| SRC | phosphorylation down-regulates | CDKN1B | SIGNOR-152831 |
| PRKAA1 | phosphorylation → up-regulates quantity by stabilization | CDKN1B | SIGNOR-259859 |
| CAMK1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-261194 |
| MAPK1 | phosphorylation → up-regulates | CDKN1B | SIGNOR-77651 |
| ERK1/2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-244622 |
| PIM1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-179300 |
| AKT | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-244194 |
| AKT1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179109 |
| CyclinY/CDK16 | phosphorylation down-regulates quantity by destabilization | CDKN1B | SIGNOR-273012 |
| DYRK1B | phosphorylation → up-regulates | CDKN1B | SIGNOR-235805 |
| UHMK1 | phosphorylation → up-regulates | CDKN1B | SIGNOR-77705 |
| CDK2 | phosphorylation down-regulates | CDKN1B | SIGNOR-154188 |
| CAMK1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-261195 |
| SRC | phosphorylation down-regulates | CDKN1B | SIGNOR-152839 |
| UHMK1 | phosphorylation → up-regulates | CDKN1B | SIGNOR-90274 |
| EPHB3 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279406 |
| MAPK3 | phosphorylation down-regulates | CDKN1B | SIGNOR-80234 |
| CDK5 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279681 |
| CDK5 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279680 |
| MAPK1 | phosphorylation → up-regulates | CDKN1B | SIGNOR-77655 |
| ATM | phosphorylation → up-regulates quantity by stabilization | CDKN1B | SIGNOR-279392 |
| JAK2 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-278260 |
| CDK16 | phosphorylation → down-regulates quantity | CDKN1B | SIGNOR-278214 |
| Gbeta | phosphorylation down-regulates | CDKN1B | SIGNOR-270087 |
| AKT | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-244202 |
| CDK6 | phosphorylation → up-regulates | CDKN1B | SIGNOR-140401 |
| PTPN11 | dephosphorylation → up-regulates activity | CDKN1B | SIGNOR-277168 |
| ABL1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-251426 |
| CDK8 | phosphorylation down-regulates | CDKN1B | SIGNOR-278513 |
| CDK16 | phosphorylation down-regulates quantity by destabilization | CDKN1B | SIGNOR-273016 |
| PIM | phosphorylation down-regulates | CDKN1B | SIGNOR-259426 |
