Summary

Name CDKN1B
Full Name Cyclin-dependent kinase inhibitor 1B
Synonyms Cyclin-dependent kinase inhibitor p27, p27Kip1 | KIP1
Primary ID P46527
Links - -
Type protein
Relations 80
Pathways Acute Myeloid Leukemia, IDH-TET in AML, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling, Tenascin-C in PDAC
Function Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.356
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png phosphorylation CDKN1B 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.369
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.254
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.347
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Integrin Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1B 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1B 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1B 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.855
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png dephosphorylation CDKN1B 0.26
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.373
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, binding CDKN1B 0.85
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.528
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1B 0.305
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.383
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.855
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.377
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.951
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1B 0.267
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.383
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.498
Publications: 3 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ down-regulates quantity img/direct_inhibition.png phosphorylation CDKN1B 0.594
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.695
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.594
Publications: 1 Organism: In Vitro
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.29
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.551
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK2 0.951
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination, ubiquitination CDKN1B 0.694
Publications: 2 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDKN1B 0.282
Publications: 1 Organism: In Vitro
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.534
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates activity img/direct_inhibition.png ubiquitination CDKN1B 0.346
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.322
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.85
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDKN1B 0.641
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK1 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.354
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/indirect_inhibition.png Cell_cycle_progress 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_cycle_block 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.746
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signaling
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling
+ down-regulates activity img/direct_inhibition.png binding CyclinE/CDK2 0.882
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling
+ up-regulates quantity by expression img/indirect-activation.png CDKN1B 0.29
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.766
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.529
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.538
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.522
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CDKN1B 0.441
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.345
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, Integrin Signaling
+ down-regulates quantity img/direct_inhibition.png relocalization CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.746
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.29
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.499
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.405
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1B 0.625
Publications: 1 Organism: Homo Sapiens