| + |
MAPK1 | up-regulates 
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77651 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 10831586 |
Phosphorylation on ser-10 of kip1 is the major site of phosphorylation in resting cells, takes place at the g(0)-g1 phase and leads to protein stability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77655 |
Ser178 |
EENVSDGsPNAGSVE |
Homo sapiens |
|
| pmid |
sentence |
| 10831586 |
Indeed, p27kip1 was phosphorylated by p42 mapk (erk2) in vitrothese results suggest that ser(10) is the major site of phosphorylation of p27(kip1) and that phosphorylation at this site, like that at thr(187), contributes to regulation of p27(kip1) stability. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DYRK1B | up-regulates
phosphorylation
|
CDKN1B |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235805 |
Ser10 |
NVRVSNGsPSLERMD |
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 15546868 |
Mirk phosphorylates p27 at ser-10, thus stabilizing p27 and blocking its nuclear export and degradation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
AKT | down-regulates activity 
phosphorylation
|
CDKN1B |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244198 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
Identification of p27kip1phosphorylation sites revealed that akt phosphorylated p27kip1at ser10(fig.4). Therefore, akt might participate in nuclear export of p27kip1as well as p27kip1degradation. Moreover, akt might be one of the unidentified ser10kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244202 |
Thr157 |
GIRKRPAtDDSSTQN |
Homo sapiens |
|
| pmid |
sentence |
| 18570873 |
Mtor may promote g1 progression in part through sgk1 activation and deregulate the cell cycle in cancers through both akt- and sgk-mediated p27 t157 phosphorylation and cytoplasmic p27 mislocalization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244194 |
Thr198 |
PGLRRRQt |
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
Identification of p27kip1phosphorylation sites revealed that akt phosphorylated p27kip1at ser10(fig.4). Therefore, akt might participate in nuclear export of p27kip1as well as p27kip1degradation. Moreover, akt might be one of the unidentified ser10kinases. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Integrin Signalling |
| + |
UHMK1 | up-regulates
phosphorylation
|
CDKN1B |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90274 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 12093740 |
Hkis is a nuclear protein that binds the c-terminal domain of p27(kip1) and phosphorylates it on s10 in vitro and in vivo, promoting its nuclear export to the cytoplasm.Phosphorylation at serine 10, a major phosphorylation site of p27(kip1), increases its protein stability |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77705 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 10831586 |
Hkis is a nuclear protein that binds the c-terminal domain of p27(kip1) and phosphorylates it on s10 in vitro and in vivo, promoting its nuclear export to the cytoplasm.Phosphorylation at serine 10, a major phosphorylation site of p27(kip1), increases its protein stability |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HIPK2 | up-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174617 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 21715331 |
Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates
phosphorylation, binding
|
CDKN1B |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88290 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
Identification of p27kip1phosphorylation sites revealed that akt phosphorylated p27kip1at ser10(fig.4). Therefore, akt might participate in nuclear export of p27kip1as well as p27kip1degradation. Moreover, akt might be one of the unidentified ser10kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179109 |
Thr157 |
GIRKRPAtDDSSTQN |
Homo sapiens |
|
| pmid |
sentence |
| 18570873 |
Mtor may promote g1 progression in part through sgk1 activation and deregulate the cell cycle in cancers through both akt- and sgk-mediated p27 t157 phosphorylation and cytoplasmic p27 mislocalization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88294 |
Thr198 |
PGLRRRQt |
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
Identification of p27kip1phosphorylation sites revealed that akt phosphorylated p27kip1at ser10(fig.4). Therefore, akt might participate in nuclear export of p27kip1as well as p27kip1degradation. Moreover, akt might be one of the unidentified ser10kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121944 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
Furthermore, akt promotes cell cycle progression through downregulation of the cyclin dependent kinase inhibitor p27kip1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23400686 |
Furthermore, akt promotes cell cycle progression through downregulation of the cyclin dependent kinase inhibitor p27kip1. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244622 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 10831586 |
Phosphorylation on ser-10 of kip1 is the major site of phosphorylation in resting cells, takes place at the g(0)-g1 phase and leads to protein stability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244517 |
Ser178 |
EENVSDGsPNAGSVE |
Homo sapiens |
|
| pmid |
sentence |
| 10831586 |
Indeed, p27kip1 was phosphorylated by p42 mapk (erk2) in vitrothese results suggest that ser(10) is the major site of phosphorylation of p27(kip1) and that phosphorylation at this site, like that at thr(187), contributes to regulation of p27(kip1) stability. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Integrin Signalling |
| + |
CDK6 | up-regulates
phosphorylation
|
CDKN1B |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140401 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
B-lymphocyte, Lymphoma Cell |
| pmid |
sentence |
| 16160006 |
Phosphorylation on ser-10 is the major site of phosphorylation in resting cells, takes place at the g(0)-g1 phase and leads to protein stability.p27(kip1) was phosphorylated by v-cyclin-cdk6 predominantly on ser10, which enhances its cytoplasmic localization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates activity
phosphorylation
|
CDKN1B |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259859 |
T198 |
PGLRRRQT |
Mus musculus |
Muscle Stem Cell |
| pmid |
sentence |
| 30033086 |
P27Kip1-Mediated Cell Survival Is Dependent on AMPK-Specific Thr198 Phosphorylation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SGK1 | down-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179117 |
Thr157 |
GIRKRPAtDDSSTQN |
Homo sapiens |
|
| pmid |
sentence |
| 18570873 |
Activated sgk1 and p27 phosphorylation at t157, and both were inhibited by short-term rapamycin treatment and by sgk1 shrna. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179121 |
Thr198 |
PGLRRRQt |
Homo sapiens |
|
| pmid |
sentence |
| 18570873 |
Activated sgk1 and p27 phosphorylation at t157, and both were inhibited by short-term rapamycin treatment and by sgk1 shrna. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93122 |
Thr157 |
GIRKRPAtDDSSTQN |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12244303 |
Akt-induced t157 phosphorylation causes retention of p27(kip1) in the cytoplasm, precluding p27(kip1)-induced g1 arrest.[__]Thus, cytoplasmic relocalization of p27(kip1), secondary to akt-mediated phosphorylation, is a novel mechanism whereby the growth inhibitory properties of p27(kip1) are functionally inactivated and the proliferation of breast cancer cells is sustained. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM1 | down-regulates
phosphorylation
|
CDKN1B |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179296 |
Thr157 |
GIRKRPAtDDSSTQN |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
We show, herein, that all the pim family members (pim1, pim2, and pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(kip1) at threonine-157 and threonine-198 residues in cells and in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179300 |
Thr198 |
PGLRRRQt |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
We show, herein, that all the pim family members (pim1, pim2, and pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(kip1) at threonine-157 and threonine-198 residues in cells and in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PIM | down-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259426 |
Thr157 |
GIRKRPAtDDSSTQN |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
We show, herein, that all the pim family members (pim1, pim2, and pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(kip1) at threonine-157 and threonine-198 residues in cells and in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259425 |
Thr198 |
PGLRRRQt |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
We show, herein, that all the pim family members (pim1, pim2, and pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(kip1) at threonine-157 and threonine-198 residues in cells and in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80234 |
Thr187 |
NAGSVEQtPKKPGLR |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 10931950 |
These data suggest that increased signaling by erbb receptors up-regulates mapk activity, which, in turn, phosphorylates and destabilizes p27, thus contributing to dysregulated cell cycle progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates
phosphorylation
|
CDKN1B |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154188 |
Thr187 |
NAGSVEQtPKKPGLR |
Homo sapiens |
|
| pmid |
sentence |
| 17409098 |
Ubiquitination and subsequent degradation play a critical role in regulating the levels of p27 during cell cycle progression. Here we provide evidence suggesting that both cdk2/e and phosphorylation of thr(187) on p27 are essential for the recognition of p27 by the scf(skp2/cks1) complex, the ubiquitin-protein isopeptide ligase (e3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80230 |
Thr187 |
NAGSVEQtPKKPGLR |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 10931950 |
Phosphorylation of kip1 on thr-187, by cdk1 and cdk2 leads to protein ubiquitination and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK6 | down-regulates
phosphorylation
|
CDKN1B |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140405 |
Thr187 |
NAGSVEQtPKKPGLR |
Homo sapiens |
B-lymphocyte, Lymphoma Cell |
| pmid |
sentence |
| 16160006 |
Phosphorylation on thr-187, by cdk2 leads to protein ubiquitination and proteasomal degradationp27(kip1) was phosphorylated by v-cyclin-cdk6 predominantly on ser10, which enhances its cytoplasmic localization. Interestingly, upon reactivation of kshv lytic cycle, v-cyclin-cdk6 phosphorylated p27(kip1) on thr187, which resulted in down-regulation of p27(kip1) protein levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152831 |
Tyr74 |
HKPLEGKyEWQEVEK |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17254967 |
Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Our data indicate that phosphorylation by src impairs the cdk2 inhibitory action of p27 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152835 |
Tyr88 |
KGSLPEFyYRPPRPP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17254967 |
Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Our data indicate that phosphorylation by src impairs the cdk2 inhibitory action of p27 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152839 |
Tyr89 |
GSLPEFYyRPPRPPK |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17254967 |
Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Our data indicate that phosphorylation by src impairs the cdk2 inhibitory action of p27 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Integrin Signalling |
| + |
LYN | down-regulates
phosphorylation
|
CDKN1B |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172904 |
Tyr88 |
KGSLPEFyYRPPRPP |
Homo sapiens |
|
| pmid |
sentence |
| 21423214 |
We previously reported that y88 phosphorylation of p27(kip1) by oncogenic tyrosine kinases impairs p27(kip1)-mediated cdk inhibition, and initiates its ubiquitin-dependent proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | down-regulates quantity
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245293 |
Tyr88 |
KGSLPEFyYRPPRPP |
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 17254966 |
A conserved tyrosine residue (Y88) in the Cdk-binding domain of p27 can be phosphorylated by the Src-family kinase Lyn and the oncogene product BCR-ABL |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | down-regulates activity
phosphorylation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251426 |
Tyr88 |
KGSLPEFyYRPPRPP |
in vitro |
|
| pmid |
sentence |
| 17254966 |
Lyn and Abl phosphorylate Y88 of p27 in vitro. phosphorylation of Y88 in p27 impaired its ability to inhibit the bound kinase complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AKT | down-regulates
binding
|
CDKN1B |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200875 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23400686 |
Furthermore, akt promotes cell cycle progression through downregulation of the cyclin dependent kinase inhibitor p27kip1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Integrin Signalling |
| + |
FOXO | up-regulates quantity
transcriptional regulation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252928 |
|
|
Mus musculus |
NIH-3T3-A14 Cell |
| pmid |
sentence |
| 10783894 |
AFX transcriptionally activates p27kip1, resulting in increased protein levels. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
YWHAH | down-regulates
binding
|
CDKN1B |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RANBP2 | down-regulates quantity
relocalization
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259115 |
|
|
Homo sapiens |
Cholangiocarcinoma Cell Line |
| pmid |
sentence |
| 28882106 |
RanBP2 can increase the sumoylation of p27kip1. In our study, the target protein p27kip1 mainly acts as a tumor-suppressor gene in the nucleus, RanBP2 and SUMO1 act as oncogenes by promoting the nuclear-cytoplasmic translocation and debilitate the G1-arrest brought by p27kip1 accumulation in the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YWHAE | down-regulates
binding
|
CDKN1B |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88297 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression 
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17283133 |
In normal primary endometrial epithelial cells (eecs), tgfbeta directly induced a dose-dependent increase in p27 protein levels and its nuclear localization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition |
| + |
MYC | down-regulates quantity by repression 
transcriptional regulation
|
CDKN1B |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107032 |
|
|
Homo sapiens |
Breast Cancer Cell, T-lymphocyte |
| pmid |
sentence |
| 11313917 |
P27(kip1) gene is a target of transcriptional repression by c-myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| Pathways: | Cell cycle: G1/S phase transition |
| + |
AKT1 | down-regulates
transcriptional regulation
|
CDKN1B |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18423396 |
Moreover, expression of p27(kip1), an inhibitor of the cell cycle, was down regulated in an akt1/pkbalpha-specific manner during adipocytedifferentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CUL1 | down-regulates quantity by destabilization
ubiquitination
|
CDKN1B |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102725 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 12835716 |
Furthermore, c-myc activation can also promote the degradation of p27kip1 protein by directly activating the cul1 gene, which encodes a critical component of the ubiquitin ligase scfskp2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity
transcriptional regulation
|
CDKN1B |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238610 |
|
|
Mus musculus |
NIH-3T3-A14 Cell |
| pmid |
sentence |
| 10783894 |
AFX transcriptionally activates p27kip1, resulting in increased protein levels. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Integrin Signalling |
| + |
AKT1 | down-regulates quantity by repression
transcriptional regulation
|
CDKN1B |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178269 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18423396 |
Moreover, expression of p27(kip1), an inhibitor of the cell cycle, was down regulated in an akt1/pkbalpha-specific manner during adipocytedifferentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXA1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN1B |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142940 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 16331276 |
We identified a foxa1 binding site within the brca1-responsive element of the p27(kip1) promoter and showed that foxa1 activated the promoter alone and in conjunction with brca1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1B | down-regulates
binding
|
CDK1 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15340381 |
P21 and p27 are key inhibitors of both cdk1 and cdk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | down-regulates
ubiquitination
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217172 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 12835716 |
Furthermore, c-myc activation can also promote the degradation of p27kip1 protein by directly activating the cul1 gene, which encodes a critical component of the ubiquitin ligase scfskp2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1B | up-regulates
|
Cell Cycle Block |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18423396 |
Moreover, expression of p27(kip1), an inhibitor of the cell cycle, was down regulated in an akt1/pkbalpha-specific manner during adipocytedifferentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition |
| + |
CDKN1B | down-regulates
|
Cell cycle progr. |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241967 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8033212 |
p27Kip1, a cyclin-dependent kinase inhibitor implicated in G1 phase arrest by TGF beta and cell-cell contact. p27Kip1 associates with cyclin E-Cdk2 complexes in vivo and in vitro, prevents their activation, and inhibits previously activated complexes, and p27Kip1 overexpression obstructs cell entry into S phase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1B | down-regulates
binding
|
CDK2 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154191 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17409098 |
P27, an important cell cycle regulator, blocks the g(1)/s transition in cells by binding and inhibiting cdk2/cyclin a and cdk2/cyclin e complexes (cdk2/e). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKP2 | down-regulates
ubiquitination
|
CDKN1B |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154194 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17409098 |
Up-regulation of skp2 by notch signaling enhances proteasome-mediated degradation of the ckis, p27 kip1 and p21 cip1, and causes premature entry into s phase. ;the recognition of p27 by skp2/cks1 of the scfskp2 complex is dictated by cycline/cdk2, providing a high affinity binding site and the phosphorylation of p27 at t187, serving here we provide evidence suggesting that both cdk2/e and phosphorylation of thr(187) on p27 are essential for the recognition of p27 by the scf(skp2/cks1) complex, the ubiquitin-protein isopeptide ligase (e3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138493 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15998794 |
Up-regulation of skp2 by notch signaling enhances proteasome-mediated degradation of the ckis, p27 kip1 and p21 cip1, and causes premature entry into s phase. ;the recognition of p27 by skp2/cks1 of the scfskp2 complex is dictated by cycline/cdk2, providing a high affinity binding site and the phosphorylation of p27 at t187, serving here we provide evidence suggesting that both cdk2/e and phosphorylation of thr(187) on p27 are essential for the recognition of p27 by the scf(skp2/cks1) complex, the ubiquitin-protein isopeptide ligase (e3). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MEN1 | up-regulates quantity by expression
transcriptional activation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255889 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15640349 |
Menin activates transcription by means of a mechanism involving recruitment of MLL to the p27Kip1 and p18Ink4c promoters and coding regions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YWHAQ | down-regulates
binding
|
CDKN1B |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88300 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRCA1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN1B |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142888 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 16331276 |
We identified a foxa1 binding site within the brca1-responsive element of the p27(kip1) promoter and showed that foxa1 activated the promoter alone and in conjunction with brca1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1B | down-regulates activity
binding
|
CyclinE/CDK2 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217505 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17409098 |
P27, an important cell cycle regulator, blocks the g(1)/s transition in cells by binding and inhibiting cdk2/cyclin a and cdk2/cyclin e complexes (cdk2/e). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition |
CDKN1B
- 
- 