Summary

Name CDKN1B
Full Name Cyclin-dependent kinase inhibitor 1B
Synonyms Cyclin-dependent kinase inhibitor p27, p27Kip1 | KIP1
Primary ID P46527
Links - -
Type protein
Relations 58
Pathways Cell cycle: G1/S phase transition, Integrin Signalling
Function Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.22
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.37
Publications: 3 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Integrin Signalling
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.48
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, binding CDKN1B 0.58
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1B
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.36
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.6
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 3 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Integrin Signalling
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png relocalization CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.28
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
Pathways:Cell cycle: G1/S phase transition
+ down-regulates img/indirect_inhibition.png transcriptional regulation CDKN1B 0.58
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDKN1B 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signalling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK1 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell Cycle Block 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ down-regulates img/indirect_inhibition.png Cell cycle progr. 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK2 0.47
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CyclinE/CDK2 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition