Summary

Name CDKN1B
Full Name Cyclin-dependent kinase inhibitor 1B
Synonyms Cyclin-dependent kinase inhibitor p27, p27Kip1 | KIP1
Primary ID P46527
Links - -
Type protein
Relations 70
Pathways Acute Myeloid Leukemia, IDH-TET in AML, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling
Function Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.367
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.381
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1B 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.258
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1B 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Integrin Signaling
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.358
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.849
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation, binding CDKN1B 0.845
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1B 0.309
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.486
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.391
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.508
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.949
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.849
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.679
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.486
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1B 0.271
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.391
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.515
Publications: 3 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.529
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CDKN1B 0.574
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.297
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.574
Publications: 1 Organism: In Vitro
Pathways:Cell cycle: G2/M phase transition
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.553
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, Integrin Signaling
+ down-regulates img/indirect_inhibition.png Cell_cycle_progress 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CDKN1B 0.453
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding CyclinE/CDK2 0.876
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.297
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.521
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK1 0.679
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.473
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_cycle_block 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates quantity img/direct_inhibition.png relocalization CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.737
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signaling
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.757
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.497
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.845
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDKN1B 0.625
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png ubiquitination CDKN1B 0.331
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.364
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.356
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ up-regulates quantity by expression img/indirect-activation.png CDKN1B 0.296
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ down-regulates img/direct_inhibition.png binding CDKN1B 0.514
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination, polyubiquitination CDKN1B 0.682
Publications: 2 Organism: Homo Sapiens, In Vitro
+ down-regulates img/direct_inhibition.png binding CDK2 0.949
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.737
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signaling