| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 21423214 | SIGNOR-278260 |
| ABL1 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 17254966 | SIGNOR-251426 |
| SRC | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates | 17254967 | SIGNOR-152835 |
| FLT3 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 28522571 | SIGNOR-269208 |
| LYN | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates | 21423214 | SIGNOR-172904 |
| ABL1 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates quantity | 17254966 | SIGNOR-245293 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 21423214 | SIGNOR-278260 |
| ABL1 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 17254966 | SIGNOR-251426 |
| SRC | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 17254967 | SIGNOR-152835 |
| FLT3 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 28522571 | SIGNOR-269208 |
| LYN | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 21423214 | SIGNOR-172904 |
| ABL1 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 17254966 | SIGNOR-245293 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-278260 |
| ABL1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-251426 |
| SRC | phosphorylation down-regulates | CDKN1B | SIGNOR-152835 |
| FLT3 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-269208 |
| LYN | phosphorylation down-regulates | CDKN1B | SIGNOR-172904 |
| ABL1 | phosphorylation → down-regulates quantity | CDKN1B | SIGNOR-245293 |
