| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18570873 | SIGNOR-179117 |
| PIM1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18593906 | SIGNOR-179296 |
| AKT2 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 12244303 | SIGNOR-93122 |
| AKT1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18570873 | SIGNOR-179109 |
| CAMK1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation up-regulates activity | 23707388 | SIGNOR-261195 |
| AKT | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates activity | 18570873 | SIGNOR-244202 |
| PIM | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18593906 | SIGNOR-259426 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179117 |
| PIM1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-179296 |
| AKT2 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 12244303 | SIGNOR-93122 |
| AKT1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179109 |
| CAMK1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation up-regulates → | CDKN1B | 23707388 | SIGNOR-261195 |
| AKT | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-244202 |
| PIM | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-259426 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179117 |
| PIM1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179296 |
| AKT2 | phosphorylation down-regulates | CDKN1B | SIGNOR-93122 |
| AKT1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179109 |
| CAMK1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-261195 |
| AKT | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-244202 |
| PIM | phosphorylation down-regulates | CDKN1B | SIGNOR-259426 |
