| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation up-regulates activity | 23707388 | SIGNOR-261194 |
| PIM1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18593906 | SIGNOR-179300 |
| AKT | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 12042314 | SIGNOR-244194 |
| SGK1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18570873 | SIGNOR-179121 |
| PIM | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18593906 | SIGNOR-259425 |
| AKT1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates | 12042314 | SIGNOR-88294 |
| PPM1G | CDKN1B | Thr198 | PGLRRRQt | dephosphorylation up-regulates activity | 27822412 | SIGNOR-277112 |
| RPS6KA1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation up-regulates activity | 19470470 | SIGNOR-279653 |
| PRKAA1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation up-regulates quantity by stabilization | 30033086 | SIGNOR-259859 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation up-regulates → | CDKN1B | 23707388 | SIGNOR-261194 |
| PIM1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-179300 |
| AKT | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 12042314 | SIGNOR-244194 |
| SGK1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179121 |
| PIM | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-259425 |
| AKT1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 12042314 | SIGNOR-88294 |
| PPM1G | dephosphorylation down-regulates ⊣ | CDKN1B PThr198 | dephosphorylation down-regulates ⊣ | CDKN1B | 27822412 | SIGNOR-277112 |
| RPS6KA1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation up-regulates → | CDKN1B | 19470470 | SIGNOR-279653 |
| PRKAA1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation up-regulates → | CDKN1B | 30033086 | SIGNOR-259859 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-261194 |
| PIM1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-179300 |
| AKT | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-244194 |
| SGK1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-179121 |
| PIM | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-259425 |
| AKT1 | phosphorylation down-regulates | CDKN1B | SIGNOR-88294 |
| PPM1G | dephosphorylation → up-regulates activity | CDKN1B | SIGNOR-277112 |
| RPS6KA1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-279653 |
| PRKAA1 | phosphorylation → up-regulates quantity by stabilization | CDKN1B | SIGNOR-259859 |
