| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | CDKN1B | Ser140 | PKTDPSDsQTGLAEQ | phosphorylation up-regulates quantity by stabilization | 27611996 | SIGNOR-279392 |
| PPM1D | CDKN1B | Ser140 | PKTDPSDsQTGLAEQ | dephosphorylation down-regulates activity | 31959038 | SIGNOR-277109 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | CDKN1B PSer140 | phosphorylation up-regulates → | CDKN1B | 27611996 | SIGNOR-279392 |
| PPM1D | dephosphorylation down-regulates ⊣ | CDKN1B PSer140 | dephosphorylation up-regulates → | CDKN1B | 31959038 | SIGNOR-277109 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates quantity by stabilization | CDKN1B | SIGNOR-279392 |
| PPM1D | dephosphorylation → down-regulates activity | CDKN1B | SIGNOR-277109 |