| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 10931950 | SIGNOR-80230 |
| CDK6 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 16160006 | SIGNOR-140405 |
| CDK2 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 17409098 | SIGNOR-154188 |
| EPHB3 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates activity | 10389236 | SIGNOR-279406 |
| MAPK3 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 10931950 | SIGNOR-80234 |
| CDK5 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates activity | 26146988 | SIGNOR-279680 |
| CDK8 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 25818643 | SIGNOR-278513 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 10931950 | SIGNOR-80230 |
| CDK6 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 16160006 | SIGNOR-140405 |
| CDK2 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 17409098 | SIGNOR-154188 |
| EPHB3 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 10389236 | SIGNOR-279406 |
| MAPK3 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 10931950 | SIGNOR-80234 |
| CDK5 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 26146988 | SIGNOR-279680 |
| CDK8 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 25818643 | SIGNOR-278513 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | CDKN1B | SIGNOR-80230 |
| CDK6 | phosphorylation down-regulates | CDKN1B | SIGNOR-140405 |
| CDK2 | phosphorylation down-regulates | CDKN1B | SIGNOR-154188 |
| EPHB3 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279406 |
| MAPK3 | phosphorylation down-regulates | CDKN1B | SIGNOR-80234 |
| CDK5 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279680 |
| CDK8 | phosphorylation down-regulates | CDKN1B | SIGNOR-278513 |
