| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates activity | 24806449 | SIGNOR-278250 |
| MAPK1 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 10831586 | SIGNOR-77651 |
| ERK1/2 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 10831586 | SIGNOR-244622 |
| CyclinY/CDK16 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates quantity by destabilization | 25205104 | SIGNOR-273012 |
| DYRK1B | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 15546868 | SIGNOR-235805 |
| UHMK1 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 10831586 | SIGNOR-77705 |
| UHMK1 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 12093740 | SIGNOR-90274 |
| CDK5 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates activity | 26146988 | SIGNOR-279681 |
| CDK16 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates quantity | 25205104 | SIGNOR-278214 |
| CDK6 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 16160006 | SIGNOR-140401 |
| CDK16 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates quantity by destabilization | 25205104 | SIGNOR-273016 |
| HIPK2 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 21715331 | SIGNOR-174617 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 24806449 | SIGNOR-278250 |
| MAPK1 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-77651 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-244622 |
| CyclinY/CDK16 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 25205104 | SIGNOR-273012 |
| DYRK1B | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 15546868 | SIGNOR-235805 |
| UHMK1 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-77705 |
| UHMK1 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 12093740 | SIGNOR-90274 |
| CDK5 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 26146988 | SIGNOR-279681 |
| CDK16 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 25205104 | SIGNOR-278214 |
| CDK6 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 16160006 | SIGNOR-140401 |
| CDK16 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 25205104 | SIGNOR-273016 |
| HIPK2 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 21715331 | SIGNOR-174617 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-278250 |
| MAPK1 | phosphorylation → up-regulates | CDKN1B | SIGNOR-77651 |
| ERK1/2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-244622 |
| CyclinY/CDK16 | phosphorylation down-regulates quantity by destabilization | CDKN1B | SIGNOR-273012 |
| DYRK1B | phosphorylation → up-regulates | CDKN1B | SIGNOR-235805 |
| UHMK1 | phosphorylation → up-regulates | CDKN1B | SIGNOR-77705 |
| UHMK1 | phosphorylation → up-regulates | CDKN1B | SIGNOR-90274 |
| CDK5 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279681 |
| CDK16 | phosphorylation → down-regulates quantity | CDKN1B | SIGNOR-278214 |
| CDK6 | phosphorylation → up-regulates | CDKN1B | SIGNOR-140401 |
| CDK16 | phosphorylation down-regulates quantity by destabilization | CDKN1B | SIGNOR-273016 |
| HIPK2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-174617 |
