Entity Details

Name LEPR
ID P48357
Role substrate
Enzymatic Domains
Fibronectin type-III 1 239-333
PROSITE-ProRule
Ig-like 331-429
Fibronectin type-III 2 539-634
PROSITE-ProRule
Fibronectin type-III 3 639-732
PROSITE-ProRule
Fibronectin type-III 4 740-833
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
JAK2LEPRTyr1141SKKTFASyMPQFQTCphosphorylation
up-regulates activity		11018044SIGNOR-263494
JAK2LEPRTyr986QRQPFVKyATLISNSphosphorylation
up-regulates activity		11018044SIGNOR-263493
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
JAK2phosphorylation
up-regulates
→
LEPR
PTyr1141		phosphorylation
up-regulates
→		LEPR11018044SIGNOR-263494
JAK2phosphorylation
up-regulates
→
LEPR
PTyr986		phosphorylation
up-regulates
→		LEPR11018044SIGNOR-263493
Regulator Mechanism/Effect Target SIGNOR-ID
JAK2phosphorylation
→
up-regulates activity 		LEPRSIGNOR-263494
JAK2phosphorylation
→
up-regulates activity 		LEPRSIGNOR-263493