Summary

Name LEPR
Full Name Leptin receptor
Synonyms LEP-R, HuB219, OB receptor, OB-R | DB, OBR
Primary ID P48357
Links - -
Type protein
Relations 12
Pathways Leptin Signaling
Function Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation LEPR 0.766
Publications: 2 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding JAK2 0.766
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding PTPN11 0.486
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates quantity img/indirect-activation.png POMC 0.486
Publications: 1
Pathways:Leptin Signaling
+ down-regulates activity img/indirect_inhibition.png AMPK 0.378
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding SH2B1 0.343
Publications: 1
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding, phosphorylation STAT3 0.751
Publications: 2 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates img/direct-activation.png binding LEPR 0.809
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates quantity img/indirect_inhibition.png AGRP 0.471
Publications: 1
Pathways:Leptin Signaling
+ down-regulates quantity img/indirect_inhibition.png NPY 0.476
Publications: 1
Pathways:Leptin Signaling