| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | SOX2 | Tyr277 | LRDMISMyLPGAEVP | phosphorylation up-regulates quantity by stabilization | 31823521 | SIGNOR-279036 |
| VRK1 | SOX2 | – | phosphorylation up-regulates activity | 27334688 | SIGNOR-279578 | |
| AKT1 | SOX2 | Thr118 | RPRRKTKtLMKKDKY | phosphorylation up-regulates quantity by stabilization | 25042802 | SIGNOR-279003 |
| CDK2 | SOX2 | Ser251 | VKSEASSsPPVVTSS | phosphorylation up-regulates activity | 26139602 | SIGNOR-279449 |
| MAPK3 | SOX2 | Ser251 | VKSEASSsPPVVTSS | phosphorylation down-regulates activity | 29556337 | SIGNOR-279071 |
| PAK6 | SOX2 | – | phosphorylation up-regulates quantity | 32721391 | SIGNOR-280060 | |
| CDK2 | SOX2 | Ser37 | AGGNQKNsPDRVKRP | phosphorylation up-regulates activity | 26139602 | SIGNOR-279448 |
| AKT1 | SOX2 | Thr116 | KYRPRRKtKTLMKKD | phosphorylation up-regulates quantity by stabilization | 30894683 | SIGNOR-277445 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | SOX2 PTyr277 | phosphorylation up-regulates → | SOX2 | 31823521 | SIGNOR-279036 |
| AKT1 | phosphorylation up-regulates → | SOX2 PThr118 | phosphorylation up-regulates → | SOX2 | 25042802 | SIGNOR-279003 |
| CDK2 | phosphorylation up-regulates → | SOX2 PSer251 | phosphorylation up-regulates → | SOX2 | 26139602 | SIGNOR-279449 |
| MAPK3 | phosphorylation up-regulates → | SOX2 PSer251 | phosphorylation down-regulates ⊣ | SOX2 | 29556337 | SIGNOR-279071 |
| CDK2 | phosphorylation up-regulates → | SOX2 PSer37 | phosphorylation up-regulates → | SOX2 | 26139602 | SIGNOR-279448 |
| AKT1 | phosphorylation up-regulates → | SOX2 PThr116 | phosphorylation up-regulates → | SOX2 | 30894683 | SIGNOR-277445 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates quantity by stabilization | SOX2 | SIGNOR-279036 |
| VRK1 | phosphorylation → up-regulates activity | SOX2 | SIGNOR-279578 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | SOX2 | SIGNOR-279003 |
| CDK2 | phosphorylation → up-regulates activity | SOX2 | SIGNOR-279449 |
| MAPK3 | phosphorylation → down-regulates activity | SOX2 | SIGNOR-279071 |
| PAK6 | phosphorylation → up-regulates quantity | SOX2 | SIGNOR-280060 |
| CDK2 | phosphorylation → up-regulates activity | SOX2 | SIGNOR-279448 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | SOX2 | SIGNOR-277445 |
