Summary

Name SOX2
Full Name Transcription factor SOX-2
Synonyms SOX2_HUMAN
Primary ID P48431
Links - -
Type protein
Relations 15
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCC3
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCC6
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.97
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOX2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SOX2 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Pluripotency
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SOX2
Publications: 1 Organism: Mus Musculus
Tissue: HEK-293T Cell
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR2E1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.01
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SOX2/POU5F1
Publications: 1 Organism: Homo Sapiens