Summary

Name SOX2
Full Name Transcription factor SOX-2
Synonyms SOX2_HUMAN
Primary ID P48431
Links - -
Type protein
Relations 18
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.499
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCC6 0.288
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SOX2 0.695
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOX2 0.835
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.383
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOX2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.322
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation SOX2 0.325
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Pluripotency 0.7
Publications: 2 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SOX2/POU5F1 0.835
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCC3 0.3
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SOX2 0.317
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.426
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR2E1 0.386
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SOX2 0.695
Publications: 1 Organism: Mus Musculus
Tissue: HEK-293T Cell
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.835
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.499
Publications: 1 Organism: Homo Sapiens