| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CC | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248506 |
| PPP3CC | FLNA | Ser2152 | TRRRRAPsVANVGSH | dephosphorylation down-regulates quantity by destabilization | 16442073 | SIGNOR-248507 |
| PPP3CC | DNM2 | Ser764 | LQSASSHsPTPQRRP | dephosphorylation unknown | 20496096 | SIGNOR-248508 |
| PPP3CC | NFATC2 | – | dephosphorylation up-regulates | 18676376 | SIGNOR-233441 | |
| PPP3CC | NFATC2 | Ser168 | YREPLCLsPASSGSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248509 |
| PPP3CC | NFATC2 | Ser171 | PLCLSPAsSGSSASF | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248510 |
| PPP3CC | NFATC2 | Ser172 | LCLSPASsGSSASFI | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248511 |
| PPP3CC | NFATC2 | Ser174 | LSPASSGsSASFISD | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248512 |
| PPP3CC | NFATC2 | Ser175 | SPASSGSsASFISDT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248513 |
| PPP3CC | NFATC2 | Ser177 | ASSGSSAsFISDTFS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248514 |
| PPP3CC | NFATC2 | Ser180 | GSSASFIsDTFSPYT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248515 |
| PPP3CC | NFATC2 | Ser213 | QNIPAHYsPRTSPIM | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248516 |
| PPP3CC | NFATC2 | Ser217 | AHYSPRTsPIMSPRT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248517 |
| PPP3CC | NFATC2 | Ser221 | PRTSPIMsPRTSLAE | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248518 |
| PPP3CC | NFATC2 | Ser268 | VALPPGAsPQRSRSP | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248519 |
| PPP3CC | NFATC2 | Ser274 | ASPQRSRsPSPQPSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248520 |
| PPP3CC | NFATC2 | Ser276 | PQRSRSPsPQPSSHV | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248521 |
| PPP3CC | NFATC2 | Ser280 | RSPSPQPsSHVAPQD | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248522 |
| PPP3CC | NFATC2 | Ser326 | PPKMWKTsPDPSPVS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248523 |
| PPP3CC | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248524 |
| PPP3CC | KSR2 | Ser198 | IRTHLSQsPRVPSKC | dephosphorylation up-regulates activity | 19560418 | SIGNOR-248525 |
| PPP3CC | KSR2 | Ser313 | TALHRSKsHEFQLGH | dephosphorylation up-regulates activity | 19560418 | SIGNOR-248527 |
| PPP3CC | KSR2 | Thr290 | NKLKPPGtPPPSSRK | dephosphorylation up-regulates activity | 19560418 | SIGNOR-248526 |
| PPP3CC | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248528 |
| PPP3CC | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248529 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CC | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248506 |
| PPP3CC | dephosphorylation down-regulates ⊣ | FLNA PSer2152 | dephosphorylation up-regulates → | FLNA | 16442073 | SIGNOR-248507 |
| PPP3CC | dephosphorylation down-regulates ⊣ | DNM2 PSer764 | dephosphorylation up-regulates → | DNM2 | 20496096 | SIGNOR-248508 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer168 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248509 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer171 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248510 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer172 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248511 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer174 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248512 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer175 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248513 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer177 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248514 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer180 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248515 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer213 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248516 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer217 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248517 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer221 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248518 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer268 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248519 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer274 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248520 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer276 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248521 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer280 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248522 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer326 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248523 |
| PPP3CC | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248524 |
| PPP3CC | dephosphorylation down-regulates ⊣ | KSR2 PSer198 | dephosphorylation down-regulates ⊣ | KSR2 | 19560418 | SIGNOR-248525 |
| PPP3CC | dephosphorylation down-regulates ⊣ | KSR2 PSer313 | dephosphorylation down-regulates ⊣ | KSR2 | 19560418 | SIGNOR-248527 |
| PPP3CC | dephosphorylation down-regulates ⊣ | KSR2 PThr290 | dephosphorylation down-regulates ⊣ | KSR2 | 19560418 | SIGNOR-248526 |
| PPP3CC | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248528 |
| PPP3CC | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248529 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP3CC | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248506 |
| PPP3CC | dephosphorylation down-regulates quantity by destabilization | FLNA | SIGNOR-248507 |
| PPP3CC | dephosphorylation → unknown | DNM2 | SIGNOR-248508 |
| PPP3CC | dephosphorylation → up-regulates | NFATC2 | SIGNOR-233441 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248509 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248510 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248511 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248512 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248513 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248514 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248515 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248516 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248517 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248518 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248519 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248520 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248521 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248522 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248523 |
| PPP3CC | dephosphorylation → unknown | PPP1R1A | SIGNOR-248524 |
| PPP3CC | dephosphorylation → up-regulates activity | KSR2 | SIGNOR-248525 |
| PPP3CC | dephosphorylation → up-regulates activity | KSR2 | SIGNOR-248527 |
| PPP3CC | dephosphorylation → up-regulates activity | KSR2 | SIGNOR-248526 |
| PPP3CC | dephosphorylation → up-regulates activity | BAD | SIGNOR-248528 |
| PPP3CC | dephosphorylation → up-regulates activity | BAD | SIGNOR-248529 |
