Entity Details

Name IDH2
ID P48735
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FLT3IDH2Tyr107SALATQKySVAVKCAphosphorylation
down-regulates activity		34289383SIGNOR-267632
CyclinA2/CDK2IDH2Thr197GTFKMVFtPKDGSGVphosphorylation
down-regulates quantity by destabilization		34929314SIGNOR-267622
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
FLT3phosphorylation
up-regulates
→
IDH2
PTyr107		phosphorylation
down-regulates
⊣		IDH234289383SIGNOR-267632
CyclinA2/CDK2phosphorylation
up-regulates
→
IDH2
PThr197		phosphorylation
down-regulates
⊣		IDH234929314SIGNOR-267622
Regulator Mechanism/Effect Target SIGNOR-ID
FLT3phosphorylation
→
down-regulates activity 		IDH2SIGNOR-267632
CyclinA2/CDK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		IDH2SIGNOR-267622