| + |
ACAT1 | down-regulates activity 
acetylation
|
IDH2 |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267627 |
Lys413 |
VESGAMTkDLAGCIH |
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 34289383 |
Mitochondrial acetyltransferase ACAT1 and deacetylase SIRT3 are responsible for acetylation and deacetylation, respectively, at K413 of mIDH2|K413 acetylation inhibits mIDH2 by simultaneously attenuating dimer formation from monomers and destabilizing dimers for conversion to monomers |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT3 | up-regulates 
deacetylation
|
IDH2 |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196617 |
Lys413 |
VESGAMTkDLAGCIH |
Homo sapiens |
|
| pmid |
sentence |
| 22416140 |
Site-specific, genetic incorporation of n(_)-acetyllysine into position 413 of idh2 revealed that acetylated idh2 displays a dramatic 44-fold loss in activity. Deacetylation by sirt3 fully restored maximum idh2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK2 | down-regulates quantity by destabilization
phosphorylation
|
IDH2 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267622 |
Thr197 |
GTFKMVFtPKDGSGV |
|
|
| pmid |
sentence |
| 34929314 |
During the cell cycle S phase, Cyclin A-CDK2 phosphorylates IDH1 on its Threonine 157 residue (Threonine 197 in IDH2) to facilitate its recognition and ubiquitination by Skp2 E3 ubiquitin, followed by degradation through 26S proteasome |
|
| Publications: |
1 |
| + |
FLT3 | down-regulates activity
phosphorylation
|
IDH2 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267632 |
Tyr107 |
SALATQKySVAVKCA |
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 34289383 |
FLT3 promotes mIDH2 acetylation through Y107 phosphorylation of mIDH2 that enhances ACAT1 recruitment, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, NPM1_new |
| + |
IDH2 | up-regulates quantity
chemical modification
|
2-oxoglutarate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261827 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29090344 |
Two of the most commonly mutated genes in AML encode for two isoforms of isocitrate dehydrogenase (IDH), IDH1 and IDH2. IDH1 and IDH2 are two isoforms of isocitrate dehydrogenase that perform crucial roles in cellular metabolism. Somatic mutations in either of these two genes impart a neomorphic enzymatic activity upon the encoded enzymes resulting in the ability to convert α-ketoglutarate (αKG) into the oncometabolite R2-hydroxyglutarate (R2-HG), which can competitively inhibit multiple αKG-dependent dioxygenases. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, Citric acid cycle, NPM1_new |
| + |
IDH2 | down-regulates quantity
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253136 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
GUCY1A2-B2 | down-regulates quantity by destabilization
ubiquitination
|
IDH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267624 |
|
|
|
|
| pmid |
sentence |
| 34929314 |
During the cell cycle S phase, Cyclin A-CDK2 phosphorylates IDH1 on its Threonine 157 residue (Threonine 197 in IDH2) to facilitate its recognition and ubiquitination by Skp2 E3 ubiquitin, followed by degradation through 26S proteasome |
|
| Publications: |
1 |
| + |
SIRT5 | up-regulates activity
catalytic activity
|
IDH2 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27113762 |
Here, we report that SIRT5 desuccinylates and deglutarylates isocitrate dehydrogenase 2 (IDH2) and glucose-6-phosphate dehydrogenase (G6PD), respectively, and thus activates both NADPH-producing enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
D-threo-isocitrate(3-) | up-regulates activity
chemical activation
|
IDH2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32943735 |
Wild-type IDH1 and IDH2 catalyze the reaction by converting isocitrate and NADP+ into α-KG and CO2 with the concomitant generation of NADPH in the cytosol and mitochondrial matrix |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
SKP2 | down-regulates quantity by destabilization
ubiquitination
|
IDH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267626 |
|
|
|
|
| pmid |
sentence |
| 34929314 |
During the cell cycle S phase, Cyclin A-CDK2 phosphorylates IDH1 on its Threonine 157 residue (Threonine 197 in IDH2) to facilitate its recognition and ubiquitination by Skp2 E3 ubiquitin, followed by degradation through 26S proteasome |
|
| Publications: |
1 |
3.0
IDH2
- 
- 