| Name | MAPKAPK2 |
| ID | P49137 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 64-325 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK2 | HSPB1 | Ser78 | PAYSRALsRQLSSGV | phosphorylation down-regulates | 12367505 | SIGNOR-94021 |
| MAPKAPK2 | ARPC5 | Ser77 | AVKDRAGsIVLKVLI | phosphorylation unknown | 12829704 | SIGNOR-250144 |
| MAPKAPK2 | ETV1 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166625 | |
| MAPKAPK2 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 12367505 | SIGNOR-94025 |
| MAPKAPK2 | ZFP36L1 | Ser54 | GGFPRRHsVTLPSSK | phosphorylation down-regulates | 18326031 | SIGNOR-161274 |
| MAPKAPK2 | CEP131 | Ser47 | KPIVRSVsVVTGSEQ | phosphorylation down-regulates quantity | 26616734 | SIGNOR-278181 |
| MAPKAPK2 | HSPB1 | Ser15 | FSLLRGPsWDPFRDW | phosphorylation down-regulates | 20626350 | SIGNOR-166629 |
| MAPKAPK2 | LIMK1 | Ser323 | KDLGRSEsLRVVCRP | phosphorylation up-regulates | 16456544 | SIGNOR-144333 |
| MAPKAPK2 | AATF | Thr366 | FTVYRNRtLQKWHDK | phosphorylation up-regulates | 22909821 | SIGNOR-191935 |
| MAPKAPK2 | ELAVL1 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166622 | |
| MAPKAPK2 | ZFP36L1 | Ser92 | RFRDRSFsEGGERLL | phosphorylation down-regulates | 18326031 | SIGNOR-161278 |
| MAPKAPK2 | ZFP36 | Ser66 | TSLVEGRsCGWVPPP | phosphorylation down-regulates activity | 14688255 | SIGNOR-250154 |
| MAPKAPK2 | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation down-regulates activity | 12861023 | SIGNOR-250151 |
| MAPKAPK2 | CDC25A | – | phosphorylation down-regulates | 17292828 | SIGNOR-152996 | |
| MAPKAPK2 | TH | Ser19 | KGFRRAVsELDAKQA | phosphorylation up-regulates activity | 11359875 | SIGNOR-250149 |
| MAPKAPK2 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 20626350 | SIGNOR-166637 |
| MAPKAPK2 | ALOX5 | Ser272 | CSLERQLsLEQEVQQ | phosphorylation up-regulates activity | 11844797 | SIGNOR-250143 |
| MAPKAPK2 | KRT20 | Ser13 | RSFHRSLsSSLQAPV | phosphorylation up-regulates activity | 20724476 | SIGNOR-263071 |
| MAPKAPK2 | HSPA1L | Ser241 | DFDNRLVsHFVEEFK | phosphorylation up-regulates activity | 31642047 | SIGNOR-273674 |
| MAPKAPK2 | TRIM29 | Ser550 | GYPSLMRsQSPKAQP | phosphorylation up-regulates activity | 24469230 | SIGNOR-273675 |
| MAPKAPK2 | PARN | Ser557 | NHYYRNNsFTAPSTV | phosphorylation down-regulates | 20932473 | SIGNOR-168377 |
| MAPKAPK2 | ETV1 | Ser191 | HRFRRQLsEPCNSFP | phosphorylation down-regulates activity | 11551945 | SIGNOR-250145 |
| MAPKAPK2 | UBE2J1 | Ser184 | KELARQIsFKAEVNS | phosphorylation down-regulates quantity by destabilization | 24020373 | SIGNOR-263091 |
| MAPKAPK2 | PIAS1 | Ser522 | DTSYINTsLIQDYRH | phosphorylation up-regulates | 23202365 | SIGNOR-199944 |
| MAPKAPK2 | RTN4 | Ser107 | VAPERQPsWDPSPVS | phosphorylation unknown | 16095439 | SIGNOR-139486 |
| MAPKAPK2 | TH | Ser40 | GQGAPGPsLTGSPWP | phosphorylation up-regulates activity | 11359875 | SIGNOR-250150 |
| MAPKAPK2 | LPCAT2 | Ser34 | PMVPRQAsFFPPPVP | phosphorylation up-regulates activity | 20663880 | SIGNOR-263077 |
| MAPKAPK2 | SRF | – | phosphorylation up-regulates | 20626350 | SIGNOR-166640 | |
| MAPKAPK2 | HNRNPA0 | Ser84 | VELKRAVsREDSARP | phosphorylation up-regulates activity | 12456657 | SIGNOR-262951 |
| MAPKAPK2 | BAG2 | Ser20 | GRFCRSSsMADRSSR | phosphorylation up-regulates | 15271996 | SIGNOR-126953 |
| MAPKAPK2 | RCSD1 | Ser244 | PPLRRSPsRTEKQEE | phosphorylation down-regulates activity | 15850461 | SIGNOR-263080 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 20626350 | SIGNOR-166619 |
| MAPKAPK2 | CEP131 | Ser78 | NNLRRSNsTTQVSQP | phosphorylation down-regulates quantity | 26616734 | SIGNOR-278182 |
| MAPKAPK2 | EEF2K | Ser377 | PPLLRPLsENSGDEN | phosphorylation unknown | 12171600 | SIGNOR-249710 |
| MAPKAPK2 | ZFP36 | Ser186 | PVLRQSIsFSGLPSG | phosphorylation down-regulates activity | 14688255 | SIGNOR-250152 |
| MAPKAPK2 | LSP1 | Ser252 | PKLARQAsIELPSMA | phosphorylation unknown | 8995217 | SIGNOR-250148 |
| MAPKAPK2 | BECN1 | Ser90 | IPPARMMsTESANSF | phosphorylation up-regulates activity | 25693418 | SIGNOR-278342 |
| MAPKAPK2 | PDE4A | Ser152 | SFLYRSDsDYDMSPK | phosphorylation down-regulates activity | 21323643 | SIGNOR-263078 |
| MAPKAPK2 | KRT20 | Ser13 | RSFHRSLsSSLQAPV | phosphorylation up-regulates activity | 20724476 | SIGNOR-263072 |
| MAPKAPK2 | HSF1 | Ser121 | NIKRKVTsVSTLKSE | phosphorylation down-regulates activity | 16278218 | SIGNOR-279541 |
| MAPKAPK2 | CASP3 | – | phosphorylation up-regulates activity | 35554104 | SIGNOR-278960 | |
| MAPKAPK2 | TCF3 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166643 | |
| MAPKAPK2 | PLK1 | Ser326 | LTIPPRFsIAPSSLD | phosphorylation up-regulates | 18695677 | SIGNOR-179968 |
| MAPKAPK2 | HSPB1 | Ser78 | PAYSRALsRQLSSGV | phosphorylation down-regulates | 20626350 | SIGNOR-166633 |
| MAPKAPK2 | ZFP36 | Ser113 | TELCRTFsESGRCRY | phosphorylation down-regulates activity | 14688255 | SIGNOR-250156 |
| MAPKAPK2 | ETV1 | Ser216 | PMYQRQMsEPNIPFP | phosphorylation down-regulates activity | 11551945 | SIGNOR-250146 |
| MAPKAPK2 | RCSD1 | Ser179 | RRFRRSQsDCGELGD | phosphorylation down-regulates activity | 15850461 | SIGNOR-263079 |
| MAPKAPK2 | ZFP36L1 | Ser203 | PRLQHSFsFAGFPSA | phosphorylation down-regulates | 18326031 | SIGNOR-161270 |
| MAPKAPK2 | AGO2 | Ser387 | SKLMRSAsFNTDPYV | phosphorylation up-regulates | 20626350 | SIGNOR-166615 |
| MAPKAPK2 | ZFP36 | Ser184 | HPPVLRQsISFSGLP | phosphorylation down-regulates activity | 14688255 | SIGNOR-250153 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17389598 | SIGNOR-153944 |
| MAPKAPK2 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 15688025 | SIGNOR-133560 |
| MAPKAPK2 | LSP1 | Ser204 | KLIDRTEsLNRSIEK | phosphorylation unknown | 8995217 | SIGNOR-250147 |
| MAPKAPK2 | ZFP36 | Ser60 | RLPGRSTsLVEGRSC | phosphorylation down-regulates activity | 14688255 | SIGNOR-250155 |
| MAPKAPK2 | POU5F1 | Ser111 | ESNSDGAsPEPCTVT | phosphorylation up-regulates activity | 32409685 | SIGNOR-279542 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8887554 | SIGNOR-44384 |
| MAPKAPK2 | SRF | Ser103 | RGLKRSLsEMEIGMV | phosphorylation unknown | 10318869 | SIGNOR-67448 |
| MAPKAPK2 | TSC2 | Ser1254 | TALYKSLsVPAASTA | phosphorylation unknown | 12582162 | SIGNOR-98201 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer78 | phosphorylation down-regulates ⊣ | HSPB1 | 12367505 | SIGNOR-94021 |
| MAPKAPK2 | phosphorylation up-regulates → | ARPC5 PSer77 | phosphorylation down-regulates ⊣ | ARPC5 | 12829704 | SIGNOR-250144 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 12367505 | SIGNOR-94025 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36L1 PSer54 | phosphorylation down-regulates ⊣ | ZFP36L1 | 18326031 | SIGNOR-161274 |
| MAPKAPK2 | phosphorylation up-regulates → | CEP131 PSer47 | phosphorylation down-regulates ⊣ | CEP131 | 26616734 | SIGNOR-278181 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer15 | phosphorylation down-regulates ⊣ | HSPB1 | 20626350 | SIGNOR-166629 |
| MAPKAPK2 | phosphorylation up-regulates → | LIMK1 PSer323 | phosphorylation up-regulates → | LIMK1 | 16456544 | SIGNOR-144333 |
| MAPKAPK2 | phosphorylation up-regulates → | AATF PThr366 | phosphorylation up-regulates → | AATF | 22909821 | SIGNOR-191935 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36L1 PSer92 | phosphorylation down-regulates ⊣ | ZFP36L1 | 18326031 | SIGNOR-161278 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer66 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250154 |
| MAPKAPK2 | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 12861023 | SIGNOR-250151 |
| MAPKAPK2 | phosphorylation up-regulates → | TH PSer19 | phosphorylation up-regulates → | TH | 11359875 | SIGNOR-250149 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 20626350 | SIGNOR-166637 |
| MAPKAPK2 | phosphorylation up-regulates → | ALOX5 PSer272 | phosphorylation up-regulates → | ALOX5 | 11844797 | SIGNOR-250143 |
| MAPKAPK2 | phosphorylation up-regulates → | KRT20 PSer13 | phosphorylation up-regulates → | KRT20 | 20724476 | SIGNOR-263071 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPA1L PSer241 | phosphorylation up-regulates → | HSPA1L | 31642047 | SIGNOR-273674 |
| MAPKAPK2 | phosphorylation up-regulates → | TRIM29 PSer550 | phosphorylation up-regulates → | TRIM29 | 24469230 | SIGNOR-273675 |
| MAPKAPK2 | phosphorylation up-regulates → | PARN PSer557 | phosphorylation down-regulates ⊣ | PARN | 20932473 | SIGNOR-168377 |
| MAPKAPK2 | phosphorylation up-regulates → | ETV1 PSer191 | phosphorylation down-regulates ⊣ | ETV1 | 11551945 | SIGNOR-250145 |
| MAPKAPK2 | phosphorylation up-regulates → | UBE2J1 PSer184 | phosphorylation down-regulates ⊣ | UBE2J1 | 24020373 | SIGNOR-263091 |
| MAPKAPK2 | phosphorylation up-regulates → | PIAS1 PSer522 | phosphorylation up-regulates → | PIAS1 | 23202365 | SIGNOR-199944 |
| MAPKAPK2 | phosphorylation up-regulates → | RTN4 PSer107 | phosphorylation down-regulates ⊣ | RTN4 | 16095439 | SIGNOR-139486 |
| MAPKAPK2 | phosphorylation up-regulates → | TH PSer40 | phosphorylation up-regulates → | TH | 11359875 | SIGNOR-250150 |
| MAPKAPK2 | phosphorylation up-regulates → | LPCAT2 PSer34 | phosphorylation up-regulates → | LPCAT2 | 20663880 | SIGNOR-263077 |
| MAPKAPK2 | phosphorylation up-regulates → | HNRNPA0 PSer84 | phosphorylation up-regulates → | HNRNPA0 | 12456657 | SIGNOR-262951 |
| MAPKAPK2 | phosphorylation up-regulates → | BAG2 PSer20 | phosphorylation up-regulates → | BAG2 | 15271996 | SIGNOR-126953 |
| MAPKAPK2 | phosphorylation up-regulates → | RCSD1 PSer244 | phosphorylation down-regulates ⊣ | RCSD1 | 15850461 | SIGNOR-263080 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 20626350 | SIGNOR-166619 |
| MAPKAPK2 | phosphorylation up-regulates → | CEP131 PSer78 | phosphorylation down-regulates ⊣ | CEP131 | 26616734 | SIGNOR-278182 |
| MAPKAPK2 | phosphorylation up-regulates → | EEF2K PSer377 | phosphorylation down-regulates ⊣ | EEF2K | 12171600 | SIGNOR-249710 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer186 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250152 |
| MAPKAPK2 | phosphorylation up-regulates → | LSP1 PSer252 | phosphorylation down-regulates ⊣ | LSP1 | 8995217 | SIGNOR-250148 |
| MAPKAPK2 | phosphorylation up-regulates → | BECN1 PSer90 | phosphorylation up-regulates → | BECN1 | 25693418 | SIGNOR-278342 |
| MAPKAPK2 | phosphorylation up-regulates → | PDE4A PSer152 | phosphorylation down-regulates ⊣ | PDE4A | 21323643 | SIGNOR-263078 |
| MAPKAPK2 | phosphorylation up-regulates → | KRT20 PSer13 | phosphorylation up-regulates → | KRT20 | 20724476 | SIGNOR-263072 |
| MAPKAPK2 | phosphorylation up-regulates → | HSF1 PSer121 | phosphorylation down-regulates ⊣ | HSF1 | 16278218 | SIGNOR-279541 |
| MAPKAPK2 | phosphorylation up-regulates → | PLK1 PSer326 | phosphorylation up-regulates → | PLK1 | 18695677 | SIGNOR-179968 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer78 | phosphorylation down-regulates ⊣ | HSPB1 | 20626350 | SIGNOR-166633 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer113 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250156 |
| MAPKAPK2 | phosphorylation up-regulates → | ETV1 PSer216 | phosphorylation down-regulates ⊣ | ETV1 | 11551945 | SIGNOR-250146 |
| MAPKAPK2 | phosphorylation up-regulates → | RCSD1 PSer179 | phosphorylation down-regulates ⊣ | RCSD1 | 15850461 | SIGNOR-263079 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36L1 PSer203 | phosphorylation down-regulates ⊣ | ZFP36L1 | 18326031 | SIGNOR-161270 |
| MAPKAPK2 | phosphorylation up-regulates → | AGO2 PSer387 | phosphorylation up-regulates → | AGO2 | 20626350 | SIGNOR-166615 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer184 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250153 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17389598 | SIGNOR-153944 |
| MAPKAPK2 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15688025 | SIGNOR-133560 |
| MAPKAPK2 | phosphorylation up-regulates → | LSP1 PSer204 | phosphorylation down-regulates ⊣ | LSP1 | 8995217 | SIGNOR-250147 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer60 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250155 |
| MAPKAPK2 | phosphorylation up-regulates → | POU5F1 PSer111 | phosphorylation up-regulates → | POU5F1 | 32409685 | SIGNOR-279542 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8887554 | SIGNOR-44384 |
| MAPKAPK2 | phosphorylation up-regulates → | SRF PSer103 | phosphorylation down-regulates ⊣ | SRF | 10318869 | SIGNOR-67448 |
| MAPKAPK2 | phosphorylation up-regulates → | TSC2 PSer1254 | phosphorylation down-regulates ⊣ | TSC2 | 12582162 | SIGNOR-98201 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-94021 |
| MAPKAPK2 | phosphorylation → unknown | ARPC5 | SIGNOR-250144 |
| MAPKAPK2 | phosphorylation → up-regulates | ETV1 | SIGNOR-166625 |
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-94025 |
| MAPKAPK2 | phosphorylation down-regulates | ZFP36L1 | SIGNOR-161274 |
| MAPKAPK2 | phosphorylation → down-regulates quantity | CEP131 | SIGNOR-278181 |
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-166629 |
| MAPKAPK2 | phosphorylation → up-regulates | LIMK1 | SIGNOR-144333 |
| MAPKAPK2 | phosphorylation → up-regulates | AATF | SIGNOR-191935 |
| MAPKAPK2 | phosphorylation → up-regulates | ELAVL1 | SIGNOR-166622 |
| MAPKAPK2 | phosphorylation down-regulates | ZFP36L1 | SIGNOR-161278 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250154 |
| MAPKAPK2 | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-250151 |
| MAPKAPK2 | phosphorylation down-regulates | CDC25A | SIGNOR-152996 |
| MAPKAPK2 | phosphorylation → up-regulates activity | TH | SIGNOR-250149 |
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-166637 |
| MAPKAPK2 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-250143 |
| MAPKAPK2 | phosphorylation → up-regulates activity | KRT20 | SIGNOR-263071 |
| MAPKAPK2 | phosphorylation → up-regulates activity | HSPA1L | SIGNOR-273674 |
| MAPKAPK2 | phosphorylation → up-regulates activity | TRIM29 | SIGNOR-273675 |
| MAPKAPK2 | phosphorylation down-regulates | PARN | SIGNOR-168377 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ETV1 | SIGNOR-250145 |
| MAPKAPK2 | phosphorylation down-regulates quantity by destabilization | UBE2J1 | SIGNOR-263091 |
| MAPKAPK2 | phosphorylation → up-regulates | PIAS1 | SIGNOR-199944 |
| MAPKAPK2 | phosphorylation → unknown | RTN4 | SIGNOR-139486 |
| MAPKAPK2 | phosphorylation → up-regulates activity | TH | SIGNOR-250150 |
| MAPKAPK2 | phosphorylation → up-regulates activity | LPCAT2 | SIGNOR-263077 |
| MAPKAPK2 | phosphorylation → up-regulates | SRF | SIGNOR-166640 |
| MAPKAPK2 | phosphorylation → up-regulates activity | HNRNPA0 | SIGNOR-262951 |
| MAPKAPK2 | phosphorylation → up-regulates | BAG2 | SIGNOR-126953 |
| MAPKAPK2 | phosphorylation → down-regulates activity | RCSD1 | SIGNOR-263080 |
| MAPKAPK2 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-166619 |
| MAPKAPK2 | phosphorylation → down-regulates quantity | CEP131 | SIGNOR-278182 |
| MAPKAPK2 | phosphorylation → unknown | EEF2K | SIGNOR-249710 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250152 |
| MAPKAPK2 | phosphorylation → unknown | LSP1 | SIGNOR-250148 |
| MAPKAPK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278342 |
| MAPKAPK2 | phosphorylation → down-regulates activity | PDE4A | SIGNOR-263078 |
| MAPKAPK2 | phosphorylation → up-regulates activity | KRT20 | SIGNOR-263072 |
| MAPKAPK2 | phosphorylation → down-regulates activity | HSF1 | SIGNOR-279541 |
| MAPKAPK2 | phosphorylation → up-regulates activity | CASP3 | SIGNOR-278960 |
| MAPKAPK2 | phosphorylation → up-regulates | TCF3 | SIGNOR-166643 |
| MAPKAPK2 | phosphorylation → up-regulates | PLK1 | SIGNOR-179968 |
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-166633 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250156 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ETV1 | SIGNOR-250146 |
| MAPKAPK2 | phosphorylation → down-regulates activity | RCSD1 | SIGNOR-263079 |
| MAPKAPK2 | phosphorylation down-regulates | ZFP36L1 | SIGNOR-161270 |
| MAPKAPK2 | phosphorylation → up-regulates | AGO2 | SIGNOR-166615 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250153 |
| MAPKAPK2 | phosphorylation → up-regulates | CREB1 | SIGNOR-153944 |
| MAPKAPK2 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-133560 |
| MAPKAPK2 | phosphorylation → unknown | LSP1 | SIGNOR-250147 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250155 |
| MAPKAPK2 | phosphorylation → up-regulates activity | POU5F1 | SIGNOR-279542 |
| MAPKAPK2 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-44384 |
| MAPKAPK2 | phosphorylation → unknown | SRF | SIGNOR-67448 |
| MAPKAPK2 | phosphorylation → unknown | TSC2 | SIGNOR-98201 |