| Name | MAPKAPK2 |
| ID | P49137 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 64-325 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | MAPKAPK2 | Thr317 | PTQRMTItEFMNHPW | phosphorylation up-regulates activity | 7592979 | SIGNOR-250102 |
| ERK1/2 | MAPKAPK2 | – | phosphorylation up-regulates | 14967450 | SIGNOR-270206 | |
| MAPK14 | MAPKAPK2 | Thr222 | TSHNSLTtPCYTPYY | phosphorylation up-regulates activity | 14499342 | SIGNOR-118040 |
| Gbeta | MAPKAPK2 | – | phosphorylation up-regulates | 14967450 | SIGNOR-270117 | |
| MAPK1 | MAPKAPK2 | Thr334 | QSTKVPQtPLHTSRV | phosphorylation up-regulates | 8846784 | SIGNOR-44347 |
| MAPK14 | MAPKAPK2 | Thr206 | PNAILKLtDFGFAKE | phosphorylation up-regulates activity | 7592979 | SIGNOR-250101 |
| MAPK14 | MAPKAPK2 | Ser272 | SNHGLAIsPGMKTRI | phosphorylation up-regulates activity | 14499342 | SIGNOR-118036 |
| MAPK1 | MAPKAPK2 | Ser272 | SNHGLAIsPGMKTRI | phosphorylation up-regulates | 8846784 | SIGNOR-44339 |
| MAPK1 | MAPKAPK2 | Thr222 | TSHNSLTtPCYTPYY | phosphorylation up-regulates | 8846784 | SIGNOR-44343 |
| MAPK14 | MAPKAPK2 | Thr334 | QSTKVPQtPLHTSRV | phosphorylation up-regulates activity | 14499342 | SIGNOR-118044 |
| MAPK3 | MAPKAPK2 | – | phosphorylation up-regulates | 14967450 | SIGNOR-121994 | |
| MAPK14 | MAPKAPK2 | Thr25 | APPPQPPtPALPHPP | phosphorylation up-regulates activity | 8846784 | SIGNOR-44351 |
| MAPK3 | MAPKAPK2 | – | phosphorylation up-regulates | 23583303 | SIGNOR-201687 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | MAPKAPK2 PThr317 | phosphorylation up-regulates → | MAPKAPK2 | 7592979 | SIGNOR-250102 |
| MAPK14 | phosphorylation up-regulates → | MAPKAPK2 PThr222 | phosphorylation up-regulates → | MAPKAPK2 | 14499342 | SIGNOR-118040 |
| MAPK1 | phosphorylation up-regulates → | MAPKAPK2 PThr334 | phosphorylation up-regulates → | MAPKAPK2 | 8846784 | SIGNOR-44347 |
| MAPK14 | phosphorylation up-regulates → | MAPKAPK2 PThr206 | phosphorylation up-regulates → | MAPKAPK2 | 7592979 | SIGNOR-250101 |
| MAPK14 | phosphorylation up-regulates → | MAPKAPK2 PSer272 | phosphorylation up-regulates → | MAPKAPK2 | 14499342 | SIGNOR-118036 |
| MAPK1 | phosphorylation up-regulates → | MAPKAPK2 PSer272 | phosphorylation up-regulates → | MAPKAPK2 | 8846784 | SIGNOR-44339 |
| MAPK1 | phosphorylation up-regulates → | MAPKAPK2 PThr222 | phosphorylation up-regulates → | MAPKAPK2 | 8846784 | SIGNOR-44343 |
| MAPK14 | phosphorylation up-regulates → | MAPKAPK2 PThr334 | phosphorylation up-regulates → | MAPKAPK2 | 14499342 | SIGNOR-118044 |
| MAPK14 | phosphorylation up-regulates → | MAPKAPK2 PThr25 | phosphorylation up-regulates → | MAPKAPK2 | 8846784 | SIGNOR-44351 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK2 | SIGNOR-250102 |
| ERK1/2 | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-270206 |
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK2 | SIGNOR-118040 |
| Gbeta | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-270117 |
| MAPK1 | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-44347 |
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK2 | SIGNOR-250101 |
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK2 | SIGNOR-118036 |
| MAPK1 | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-44339 |
| MAPK1 | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-44343 |
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK2 | SIGNOR-118044 |
| MAPK3 | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-121994 |
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK2 | SIGNOR-44351 |
| MAPK3 | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-201687 |