| Name | CDK8 |
| ID | P49336 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 21-335 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | SREBF1 | Thr426 | TEVEDTLtPPPSDAG | phosphorylation up-regulates activity | 23562092 | SIGNOR-279688 |
| CDK8 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 29239838 | SIGNOR-273179 |
| CDK8 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 25818643 | SIGNOR-278513 |
| CDK8 | NOTCH1 | – | phosphorylation down-regulates | 15546612 | SIGNOR-130640 | |
| CDK8 | NOTCH1 | Ser2513 | EHPFLTPsPESPDQW | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273176 |
| CDK8 | NOTCH1 | Ser2516 | FLTPSPEsPDQWSSS | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273177 |
| CDK8 | NOTCH1 | Thr2511 | VPEHPFLtPSPESPD | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273178 |
| CDK8 | YAP1 | Ser128 | QHVRAHSsPASLQLG | phosphorylation up-regulates activity | 29967145 | SIGNOR-277649 |
| CDK8 | YAP1 | Ser289 | PPPLAPQsPQGGVMG | phosphorylation up-regulates activity | 29967145 | SIGNOR-277650 |
| CDK8 | YAP1 | Ser367 | GTQNPVSsPGMSQEL | phosphorylation up-regulates activity | 29967145 | SIGNOR-277651 |
| CDK8 | YAP1 | Thr119 | AGTAGALtPQHVRAH | phosphorylation up-regulates activity | 29967145 | SIGNOR-277648 |
| CDK8 | CCNH | Ser304 | YEDDDYVsKKSKHEE | phosphorylation down-regulates | 10993082 | SIGNOR-82033 |
| CDK8 | CCNH | Ser5 | sSQKRHWT | phosphorylation down-regulates | 10993082 | SIGNOR-82037 |
| CDK8 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273171 |
| CDK8 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914161 | SIGNOR-161557 |
| CDK8 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914168 | SIGNOR-161646 |
| CDK8 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-161553 |
| CDK8 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19914161 | SIGNOR-161561 |
| CDK8 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273173 |
| CDK8 | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates | 18794899 | SIGNOR-181078 |
| CDK8 | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates | 22945643 | SIGNOR-198934 |
| CDK8 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | phosphorylation down-regulates | 19914161 | SIGNOR-189129 |
| CDK8 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914161 | SIGNOR-189133 |
| CDK8 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914161 | SIGNOR-189141 |
| CDK8 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914168 | SIGNOR-161626 |
| CDK8 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914168 | SIGNOR-161634 |
| CDK8 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-189137 |
| CDK8 | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273175 |
| CDK8 | MED13 | – | phosphorylation down-regulates quantity by destabilization | 29212878 | SIGNOR-279687 | |
| CDK8 | NOTCH | – | phosphorylation down-regulates | 15546612 | SIGNOR-254312 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | phosphorylation up-regulates → | SREBF1 PThr426 | phosphorylation up-regulates → | SREBF1 | 23562092 | SIGNOR-279688 |
| CDK8 | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 29239838 | SIGNOR-273179 |
| CDK8 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 25818643 | SIGNOR-278513 |
| CDK8 | phosphorylation up-regulates → | NOTCH1 PSer2513 | phosphorylation down-regulates ⊣ | NOTCH1 | 25344755 | SIGNOR-273176 |
| CDK8 | phosphorylation up-regulates → | NOTCH1 PSer2516 | phosphorylation down-regulates ⊣ | NOTCH1 | 25344755 | SIGNOR-273177 |
| CDK8 | phosphorylation up-regulates → | NOTCH1 PThr2511 | phosphorylation down-regulates ⊣ | NOTCH1 | 25344755 | SIGNOR-273178 |
| CDK8 | phosphorylation up-regulates → | YAP1 PSer128 | phosphorylation up-regulates → | YAP1 | 29967145 | SIGNOR-277649 |
| CDK8 | phosphorylation up-regulates → | YAP1 PSer289 | phosphorylation up-regulates → | YAP1 | 29967145 | SIGNOR-277650 |
| CDK8 | phosphorylation up-regulates → | YAP1 PSer367 | phosphorylation up-regulates → | YAP1 | 29967145 | SIGNOR-277651 |
| CDK8 | phosphorylation up-regulates → | YAP1 PThr119 | phosphorylation up-regulates → | YAP1 | 29967145 | SIGNOR-277648 |
| CDK8 | phosphorylation up-regulates → | CCNH PSer304 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-82033 |
| CDK8 | phosphorylation up-regulates → | CCNH PSer5 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-82037 |
| CDK8 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 18418385 | SIGNOR-273171 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161557 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161646 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161553 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161561 |
| CDK8 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 18418385 | SIGNOR-273173 |
| CDK8 | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 18794899 | SIGNOR-181078 |
| CDK8 | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 22945643 | SIGNOR-198934 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer187 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189129 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189133 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189141 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161626 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161634 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189137 |
| CDK8 | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 18418385 | SIGNOR-273175 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK8 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279688 |
| CDK8 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-273179 |
| CDK8 | phosphorylation down-regulates | CDKN1B | SIGNOR-278513 |
| CDK8 | phosphorylation down-regulates | NOTCH1 | SIGNOR-130640 |
| CDK8 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273176 |
| CDK8 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273177 |
| CDK8 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273178 |
| CDK8 | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277649 |
| CDK8 | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277650 |
| CDK8 | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277651 |
| CDK8 | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277648 |
| CDK8 | phosphorylation down-regulates | CCNH | SIGNOR-82033 |
| CDK8 | phosphorylation down-regulates | CCNH | SIGNOR-82037 |
| CDK8 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-273171 |
| CDK8 | phosphorylation down-regulates | SMAD3 | SIGNOR-161557 |
| CDK8 | phosphorylation down-regulates | SMAD3 | SIGNOR-161646 |
| CDK8 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161553 |
| CDK8 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161561 |
| CDK8 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-273173 |
| CDK8 | phosphorylation down-regulates | E2F1 | SIGNOR-181078 |
| CDK8 | phosphorylation down-regulates | E2F1 | SIGNOR-198934 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-189129 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-189133 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-189141 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-161626 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-161634 |
| CDK8 | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-189137 |
| CDK8 | phosphorylation → down-regulates activity | H3-4 | SIGNOR-273175 |
| CDK8 | phosphorylation down-regulates quantity by destabilization | MED13 | SIGNOR-279687 |
| CDK8 | phosphorylation down-regulates | NOTCH | SIGNOR-254312 |