Summary

Name CDK8
Full Name Cyclin-dependent kinase 8
Synonyms Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35
Primary ID P49336
Links - -
Type protein
Relations 27
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation H3-4 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation SMAD1 0.394
Publications: 5 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SMAD1 0.394
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.544
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.544
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH1 0.532
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CCNH 0.673
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation E2F1 0.5
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.407
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, relocalization CDK8 0.577
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH 0.532
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CKM complex 0.898
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.532
Publications: 1 Organism: Homo Sapiens