| Name | CLK2 |
| ID | P49760 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 163-479 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK2 | PTPN1 | Ser242 | MDKRKDPsSVDIKKV | phosphorylation up-regulates activity | 10480872 | SIGNOR-250775 |
| CLK2 | PTPN1 | Ser243 | DKRKDPSsVDIKKVL | phosphorylation up-regulates activity | 10480872 | SIGNOR-250776 |
| CLK2 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation up-regulates activity | 10480872 | SIGNOR-70603 |
| CLK2 | CLK2 | Ser142 | HSSRRAKsVEDDAEG | phosphorylation up-regulates | 20682768 | SIGNOR-167344 |
| CLK2 | SRSF1 | – | phosphorylation up-regulates activity | 8617202 | SIGNOR-273858 | |
| CLK2 | PPARGC1A | – | phosphorylation down-regulates activity | 20074525 | SIGNOR-278228 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer242 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250775 |
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer243 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250776 |
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-70603 |
| CLK2 | phosphorylation up-regulates → | CLK2 PSer142 | phosphorylation up-regulates → | CLK2 | 20682768 | SIGNOR-167344 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250775 |
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250776 |
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-70603 |
| CLK2 | phosphorylation → up-regulates | CLK2 | SIGNOR-167344 |
| CLK2 | phosphorylation → up-regulates activity | SRSF1 | SIGNOR-273858 |
| CLK2 | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-278228 |