Summary

Name CLK2
Full Name Dual specificity protein kinase CLK2
Synonyms CDC-like kinase 2
Primary ID P49760
Links - -
Type protein
Relations 8
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CLK2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.37
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CLK2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CLK2 0.07
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN1 0.37
Publications: 1 Organism: Homo Sapiens