Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT1	CLK2	Ser34	HKRRRSRsWSSSSDR	phosphorylation up-regulates	20682768	SIGNOR-167336
AKT1	CLK2	Thr127	RRRRRSRtFSRSSSQ	phosphorylation up-regulates	20682768	SIGNOR-167340
AKT	CLK2	Thr127	RRRRRSRtFSRSSSQ	phosphorylation up-regulates	20682768	SIGNOR-244218
AKT	CLK2	Ser34	HKRRRSRsWSSSSDR	phosphorylation up-regulates	20682768	SIGNOR-244214
CLK2	CLK2	Ser142 View in OncoXplorer	HSSRRAKsVEDDAEG	phosphorylation up-regulates	20682768	SIGNOR-167344

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT1	phosphorylation up-regulates →	CLK2 PSer34	phosphorylation up-regulates →	CLK2	20682768	SIGNOR-167336
AKT1	phosphorylation up-regulates →	CLK2 PThr127	phosphorylation up-regulates →	CLK2	20682768	SIGNOR-167340
AKT	phosphorylation up-regulates →	CLK2 PThr127	phosphorylation up-regulates →	CLK2	20682768	SIGNOR-244218
AKT	phosphorylation up-regulates →	CLK2 PSer34	phosphorylation up-regulates →	CLK2	20682768	SIGNOR-244214
CLK2	phosphorylation up-regulates →	CLK2 PSer142	phosphorylation up-regulates →	CLK2	20682768	SIGNOR-167344

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT1	phosphorylation → up-regulates	CLK2	SIGNOR-167336
AKT1	phosphorylation → up-regulates	CLK2	SIGNOR-167340
AKT	phosphorylation → up-regulates	CLK2	SIGNOR-244218
AKT	phosphorylation → up-regulates	CLK2	SIGNOR-244214
CLK2	phosphorylation → up-regulates	CLK2	SIGNOR-167344