| Name | LIG4 |
| ID | P49917 |
| Role | substrate |
| Enzymatic Domains | Warning: file_get_contents(https://rest.uniprot.org/uniprotkb/P49917.json): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 6 Warning: Trying to access array offset on value of type null in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 8 Warning: foreach() argument must be of type array|object, null given in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 8 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | LIG4 | Ser672 | CVMSGTDsQPKPDLE | phosphorylation down-regulates | 15194694 | SIGNOR-125873 |
| PRKDC | LIG4 | Thr650 | HLKAPNLtNVNKISN | phosphorylation down-regulates | 15194694 | SIGNOR-125877 |
| PRKDC | LIG4 | Ser668 | DVEFCVMsGTDSQPK | phosphorylation down-regulates | 15194694 | SIGNOR-125869 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | phosphorylation up-regulates → | LIG4 PSer672 | phosphorylation down-regulates ⊣ | LIG4 | 15194694 | SIGNOR-125873 |
| PRKDC | phosphorylation up-regulates → | LIG4 PThr650 | phosphorylation down-regulates ⊣ | LIG4 | 15194694 | SIGNOR-125877 |
| PRKDC | phosphorylation up-regulates → | LIG4 PSer668 | phosphorylation down-regulates ⊣ | LIG4 | 15194694 | SIGNOR-125869 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKDC | phosphorylation![]() down-regulates | LIG4 | SIGNOR-125873 |
| PRKDC | phosphorylation![]() down-regulates | LIG4 | SIGNOR-125877 |
| PRKDC | phosphorylation![]() down-regulates | LIG4 | SIGNOR-125869 |