Name LIG4
Full Name DNA ligase 4
Synonyms DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4
Primary ID P49917
Links - -
Type protein
Relations 3
Function Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.


Modifications Tables


Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation LIG4 0.22
Publications: 3 Organism: Homo Sapiens