| Name | DNM2 |
| ID | P50570 |
| Role | substrate |
| Enzymatic Domains |
Dynamin-type G 28-294 PROSITE-ProRule
PH 519-625 PROSITE-ProRule
GED 653-744 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | DNM2 | Tyr231 | LLPLRRGyIGVVNRS | phosphorylation up-regulates activity | 32457704 | SIGNOR-279485 |
| SRC | DNM2 | Tyr597 | NTEQRNVyKDLRQIE | phosphorylation up-regulates activity | 32457704 | SIGNOR-279486 |
| Calcineurin | DNM2 | Ser764 | LQSASSHsPTPQRRP | dephosphorylation unknown | 20496096 | SIGNOR-252317 |
| PP2B | DNM2 | – | dephosphorylation unknown | 20496096 | SIGNOR-269990 | |
| SRC | DNM2 | Tyr597 | NTEQRNVyKDLRQIE | phosphorylation down-regulates activity | 33113375 | SIGNOR-277539 |
| PPP3CC | DNM2 | Ser764 | LQSASSHsPTPQRRP | dephosphorylation unknown | 20496096 | SIGNOR-248508 |
| PPP3CB | DNM2 | Ser764 | LQSASSHsPTPQRRP | dephosphorylation unknown | 20496096 | SIGNOR-248363 |
| PPP3CA | DNM2 | Ser764 | LQSASSHsPTPQRRP | dephosphorylation unknown | 20496096 | SIGNOR-248677 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | DNM2 PTyr231 | phosphorylation up-regulates → | DNM2 | 32457704 | SIGNOR-279485 |
| SRC | phosphorylation up-regulates → | DNM2 PTyr597 | phosphorylation up-regulates → | DNM2 | 32457704 | SIGNOR-279486 |
| Calcineurin | dephosphorylation down-regulates ⊣ | DNM2 PSer764 | dephosphorylation up-regulates → | DNM2 | 20496096 | SIGNOR-252317 |
| SRC | phosphorylation up-regulates → | DNM2 PTyr597 | phosphorylation down-regulates ⊣ | DNM2 | 33113375 | SIGNOR-277539 |
| PPP3CC | dephosphorylation down-regulates ⊣ | DNM2 PSer764 | dephosphorylation up-regulates → | DNM2 | 20496096 | SIGNOR-248508 |
| PPP3CB | dephosphorylation down-regulates ⊣ | DNM2 PSer764 | dephosphorylation up-regulates → | DNM2 | 20496096 | SIGNOR-248363 |
| PPP3CA | dephosphorylation down-regulates ⊣ | DNM2 PSer764 | dephosphorylation up-regulates → | DNM2 | 20496096 | SIGNOR-248677 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | DNM2 | SIGNOR-279485 |
| SRC | phosphorylation → up-regulates activity | DNM2 | SIGNOR-279486 |
| Calcineurin | dephosphorylation → unknown | DNM2 | SIGNOR-252317 |
| PP2B | dephosphorylation → unknown | DNM2 | SIGNOR-269990 |
| SRC | phosphorylation → down-regulates activity | DNM2 | SIGNOR-277539 |
| PPP3CC | dephosphorylation → unknown | DNM2 | SIGNOR-248508 |
| PPP3CB | dephosphorylation → unknown | DNM2 | SIGNOR-248363 |
| PPP3CA | dephosphorylation → unknown | DNM2 | SIGNOR-248677 |