| Name | CDK7 |
| ID | P50613 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 12-295 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK7 | MBD4 | – | phosphorylation down-regulates activity | 31466944 | SIGNOR-279686 | |
| CDK7 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10949034 | SIGNOR-81170 |
| CDK7 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 9372954 | SIGNOR-53311 |
| CDK7 | TP53 | Ser371 | AHSSHLKsKKGQSTS | phosphorylation up-regulates | 9315650 | SIGNOR-51280 |
| CDK7 | TP53 | Ser376 | LKSKKGQsTSRHKKL | phosphorylation up-regulates | 9315650 | SIGNOR-51284 |
| CDK7 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates | 9315650 | SIGNOR-51288 |
| CDK7 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 9315650 | SIGNOR-51292 |
| CDK7 | CDK1 | Thr161 | GIPIRVYtHEVVTLW | phosphorylation up-regulates | 8344251 | SIGNOR-38307 |
| CDK7 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 21157430 | SIGNOR-170599 |
| CDK7 | RARA | Ser77 | EIVPSPPsPPPLPRI | phosphorylation unknown | 11955452 | SIGNOR-116582 |
| CDK7 | RARA | Ser77 | EIVPSPPsPPPLPRI | phosphorylation up-regulates | 9230306 | SIGNOR-49693 |
| CDK7 | CDK4 | Thr172 | YSYQMALtPVVVTLW | phosphorylation up-regulates | 8139570 | SIGNOR-36549 |
| CDK7 | RARG | Ser77 | SEEMVPSsPSPPPPP | phosphorylation up-regulates activity | 10748061 | SIGNOR-259853 |
| CDK7 | RARG | Ser79 | EMVPSSPsPPPPPRV | phosphorylation up-regulates activity | 10748061 | SIGNOR-259852 |
| CDK7 | RARG | Ser79 | EMVPSSPsPPPPPRV | phosphorylation up-regulates activity | 10748061 | SIGNOR-277897 |
| CDK7 | RARG | Ser79 | EMVPSSPsPPPPPRV | phosphorylation up-regulates activity | 10748061 | SIGNOR-277896 |
| CDK7 | ERCC3 | Ser90 | HIFLEAFsPVYKYAQ | phosphorylation down-regulates quantity by destabilization | 30762924 | SIGNOR-277433 |
| CDK7 | CDK11B | Thr595 | GSPLKAYtPVVVTLW | phosphorylation up-regulates activity | 16327805 | SIGNOR-245871 |
| CDK7 | POLR2A | Ser1619 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-119992 |
| CDK7 | POLR2A | Ser1626 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-119996 |
| CDK7 | POLR2A | Ser1647 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120000 |
| CDK7 | POLR2A | Ser1654 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120004 |
| CDK7 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120008 |
| CDK7 | POLR2A | Ser1675 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120012 |
| CDK7 | POLR2A | Ser1696 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120016 |
| CDK7 | POLR2A | Ser1717 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120020 |
| CDK7 | POLR2A | Ser1724 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120024 |
| CDK7 | POLR2A | Ser1738 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120028 |
| CDK7 | POLR2A | Ser1766 | SPSYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120032 |
| CDK7 | POLR2A | Ser1787 | SPNYSPTsPSYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120036 |
| CDK7 | POLR2A | Ser1864 | SPKYSPTsPKYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120040 |
| CDK7 | POLR2A | Ser1871 | SPKYSPTsPKYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120044 |
| CDK7 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation down-regulates | 14662762 | SIGNOR-120048 |
| CDK7 | POLR2A | Ser1892 | TPKYSPTsPTYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120052 |
| CDK7 | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120056 |
| CDK7 | POLR2A | Ser1913 | SPKYSPTsPTYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120060 |
| CDK7 | POLR2A | Ser1920 | SPTYSPTsPKYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120064 |
| CDK7 | POLR2A | Ser1927 | SPKYSPTsPTYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120068 |
| CDK7 | POLR2A | Ser1934 | SPTYSPTsPKGSTYS | phosphorylation down-regulates | 14662762 | SIGNOR-120072 |
| CDK7 | POLR2A | Ser1944 | GSTYSPTsPGYSPTS | phosphorylation down-regulates | 14662762 | SIGNOR-120076 |
| CDK7 | POLR2A | Ser1951 | SPGYSPTsPTYSLTS | phosphorylation down-regulates | 14662762 | SIGNOR-120080 |
| CDK7 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates activity | 10085115 | SIGNOR-250768 |
| CDK7 | MCM2 | Ser139 | RRGLLYDsDEEDEER | phosphorylation up-regulates activity | 16899510 | SIGNOR-259850 |
| CDK7 | MCM2 | Ser27 | GNDPLTSsPGRSSRR | phosphorylation up-regulates activity | 16899510 | SIGNOR-259848 |
| CDK7 | MCM2 | Ser41 | RTDALTSsPGRDLPP | phosphorylation up-regulates activity | 16899510 | SIGNOR-259849 |
| CDK7 | CDK9 | Thr186 | NSQPNRYtNRVVTLW | phosphorylation up-regulates activity | 23064645 | SIGNOR-279455 |
| CDK7 | CDK5 | Ser159 | GIPVRCYsAEVVTLW | phosphorylation up-regulates activity | 14586172 | SIGNOR-278923 |
| CDK7 | E2F1 | Ser403 | PEEFISLsPPHEALD | phosphorylation down-regulates | 10428966 | SIGNOR-69776 |
| CDK7 | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates | 10428966 | SIGNOR-69780 |
| CDK7 | POU5F1 | Ser12 | LASDFAFsPPPGGGG | phosphorylation up-regulates quantity by stabilization | 31306665 | SIGNOR-264404 |
| CDK7 | NR5A1 | Ser203 | EYPEPYAsPPQPGLP | phosphorylation up-regulates | 17901130 | SIGNOR-157952 |
| CDK7 | PCGF6 | Ser30 | LPPPPPVsPPALTPA | phosphorylation unknown | 12167161 | SIGNOR-250769 |
| CDK7 | XRN2 | Thr439 | FTPSGILtPHALGSR | phosphorylation up-regulates activity | 26728557 | SIGNOR-259851 |
| CDK7 | CDK12 | Thr893 | SEESRPYtNKVITLW | phosphorylation up-regulates activity | 24662513 | SIGNOR-275509 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK7 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-81170 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 9372954 | SIGNOR-53311 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer371 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51280 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer376 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51284 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51288 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51292 |
| CDK7 | phosphorylation up-regulates → | CDK1 PThr161 | phosphorylation up-regulates → | CDK1 | 8344251 | SIGNOR-38307 |
| CDK7 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 21157430 | SIGNOR-170599 |
| CDK7 | phosphorylation up-regulates → | RARA PSer77 | phosphorylation down-regulates ⊣ | RARA | 11955452 | SIGNOR-116582 |
| CDK7 | phosphorylation up-regulates → | RARA PSer77 | phosphorylation up-regulates → | RARA | 9230306 | SIGNOR-49693 |
| CDK7 | phosphorylation up-regulates → | CDK4 PThr172 | phosphorylation up-regulates → | CDK4 | 8139570 | SIGNOR-36549 |
| CDK7 | phosphorylation up-regulates → | RARG PSer77 | phosphorylation up-regulates → | RARG | 10748061 | SIGNOR-259853 |
| CDK7 | phosphorylation up-regulates → | RARG PSer79 | phosphorylation up-regulates → | RARG | 10748061 | SIGNOR-259852 |
| CDK7 | phosphorylation up-regulates → | RARG PSer79 | phosphorylation up-regulates → | RARG | 10748061 | SIGNOR-277897 |
| CDK7 | phosphorylation up-regulates → | RARG PSer79 | phosphorylation up-regulates → | RARG | 10748061 | SIGNOR-277896 |
| CDK7 | phosphorylation up-regulates → | ERCC3 PSer90 | phosphorylation down-regulates ⊣ | ERCC3 | 30762924 | SIGNOR-277433 |
| CDK7 | phosphorylation up-regulates → | CDK11B PThr595 | phosphorylation up-regulates → | CDK11B | 16327805 | SIGNOR-245871 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1619 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-119992 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1626 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-119996 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1647 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120000 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1654 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120004 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120008 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1675 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120012 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1696 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120016 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1717 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120020 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1724 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120024 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1738 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120028 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1766 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120032 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1787 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120036 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1864 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120040 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1871 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120044 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120048 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1892 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120052 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120056 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1913 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120060 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1920 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120064 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1927 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120068 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1934 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120072 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1944 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120076 |
| CDK7 | phosphorylation up-regulates → | POLR2A PSer1951 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-120080 |
| CDK7 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 10085115 | SIGNOR-250768 |
| CDK7 | phosphorylation up-regulates → | MCM2 PSer139 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-259850 |
| CDK7 | phosphorylation up-regulates → | MCM2 PSer27 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-259848 |
| CDK7 | phosphorylation up-regulates → | MCM2 PSer41 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-259849 |
| CDK7 | phosphorylation up-regulates → | CDK9 PThr186 | phosphorylation up-regulates → | CDK9 | 23064645 | SIGNOR-279455 |
| CDK7 | phosphorylation up-regulates → | CDK5 PSer159 | phosphorylation up-regulates → | CDK5 | 14586172 | SIGNOR-278923 |
| CDK7 | phosphorylation up-regulates → | E2F1 PSer403 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-69776 |
| CDK7 | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-69780 |
| CDK7 | phosphorylation up-regulates → | POU5F1 PSer12 | phosphorylation up-regulates → | POU5F1 | 31306665 | SIGNOR-264404 |
| CDK7 | phosphorylation up-regulates → | NR5A1 PSer203 | phosphorylation up-regulates → | NR5A1 | 17901130 | SIGNOR-157952 |
| CDK7 | phosphorylation up-regulates → | PCGF6 PSer30 | phosphorylation down-regulates ⊣ | PCGF6 | 12167161 | SIGNOR-250769 |
| CDK7 | phosphorylation up-regulates → | XRN2 PThr439 | phosphorylation up-regulates → | XRN2 | 26728557 | SIGNOR-259851 |
| CDK7 | phosphorylation up-regulates → | CDK12 PThr893 | phosphorylation up-regulates → | CDK12 | 24662513 | SIGNOR-275509 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK7 | phosphorylation → down-regulates activity | MBD4 | SIGNOR-279686 |
| CDK7 | phosphorylation → up-regulates | ESR1 | SIGNOR-81170 |
| CDK7 | phosphorylation → unknown | TP53 | SIGNOR-53311 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51280 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51284 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51288 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51292 |
| CDK7 | phosphorylation → up-regulates | CDK1 | SIGNOR-38307 |
| CDK7 | phosphorylation down-regulates | AR | SIGNOR-170599 |
| CDK7 | phosphorylation → unknown | RARA | SIGNOR-116582 |
| CDK7 | phosphorylation → up-regulates | RARA | SIGNOR-49693 |
| CDK7 | phosphorylation → up-regulates | CDK4 | SIGNOR-36549 |
| CDK7 | phosphorylation → up-regulates activity | RARG | SIGNOR-259853 |
| CDK7 | phosphorylation → up-regulates activity | RARG | SIGNOR-259852 |
| CDK7 | phosphorylation → up-regulates activity | RARG | SIGNOR-277897 |
| CDK7 | phosphorylation → up-regulates activity | RARG | SIGNOR-277896 |
| CDK7 | phosphorylation down-regulates quantity by destabilization | ERCC3 | SIGNOR-277433 |
| CDK7 | phosphorylation → up-regulates activity | CDK11B | SIGNOR-245871 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-119992 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-119996 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120000 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120004 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120008 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120012 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120016 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120020 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120024 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120028 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120032 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120036 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120040 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120044 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120048 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120052 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120056 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120060 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120064 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120068 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120072 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120076 |
| CDK7 | phosphorylation down-regulates | POLR2A | SIGNOR-120080 |
| CDK7 | phosphorylation → up-regulates activity | CDK2 | SIGNOR-250768 |
| CDK7 | phosphorylation → up-regulates activity | MCM2 | SIGNOR-259850 |
| CDK7 | phosphorylation → up-regulates activity | MCM2 | SIGNOR-259848 |
| CDK7 | phosphorylation → up-regulates activity | MCM2 | SIGNOR-259849 |
| CDK7 | phosphorylation → up-regulates activity | CDK9 | SIGNOR-279455 |
| CDK7 | phosphorylation → up-regulates activity | CDK5 | SIGNOR-278923 |
| CDK7 | phosphorylation down-regulates | E2F1 | SIGNOR-69776 |
| CDK7 | phosphorylation down-regulates | E2F1 | SIGNOR-69780 |
| CDK7 | phosphorylation → up-regulates quantity by stabilization | POU5F1 | SIGNOR-264404 |
| CDK7 | phosphorylation → up-regulates | NR5A1 | SIGNOR-157952 |
| CDK7 | phosphorylation → unknown | PCGF6 | SIGNOR-250769 |
| CDK7 | phosphorylation → up-regulates activity | XRN2 | SIGNOR-259851 |
| CDK7 | phosphorylation → up-regulates activity | CDK12 | SIGNOR-275509 |