Relation Results

Summary

Name CDK7
Full Name Cyclin-dependent kinase 7
Synonyms 39 kDa protein kinase, p39 Mo15, CDK-activating kinase 1, Cell division protein kinase 7, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit | CAK, CAK1, CDKN7, MO15, STK1
Primary ID P50613
Links - -
Type protein
Relations 61
Inhibitors PHA-767491; N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide; BS-181 hydrochloride; N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide; alvocidib
Function Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activa ...
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Type: Score: Layout: SPV 
0.4140.20.30.7890.6430.5690.3670.3050.460.4950.3780.4160.5440.8950.5690.5790.5850.2470.3360.5080.80.80.9590.80.80.8CDK7ESR1POU5F1MCM2POLR2ACyclinA2/CDK2CDK2NR5A1PCGF6TP53E2F1ARRARGRARAERCC3CDK1CDK4XRN2CDK11BCDK12PHA-767491N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamideCAK complexBS-181 hydrochlorideN-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamidealvocidib

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK7up-regulates img/direct-activation.png phosphorylation ESR1 0.414
Identifier Residue Sequence Organism Cell Line
SIGNOR-81170 Ser118 LHPPPQLsPFLQPHG Homo sapiens
pmid sentence
Activation of estrogen receptor alpha by s118 phosphorylation involves a ligand-dependent interaction with tfiih and participation of cdk7.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates quantity by stabilization img/direct-activation.png phosphorylation POU5F1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264404 Ser12 LASDFAFsPPPGGGG Homo sapiens Embryonic Stem Cell
pmid sentence
Here, we combined molecular and cellular biology with CRISPR/Cas9-mediated genome engineering to pinpoint the function of serine 12 of OCT4 in ESCs. Using chemical inhibitors and an antibody specific to OCT4 phosphorylated on S12, we identified cyclin-dependent kinase (CDK) 7 as upstream kinase. |Phosphorylation of OCT4 on S12 has been previously implicated to stabilize OCT4 by binding to PIN1, thereby preventing ubiquitinylation by WWP2.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates activity img/direct-activation.png phosphorylation MCM2 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-259850 Ser139 RRGLLYDsDEEDEER Homo sapiens
pmid sentence
Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. | Because MCM2 was phosphorylated in vivo at Ser27, Ser41, and Ser139, which were phosphorylated by Cdc7/Dbf4 in vitro, the results suggested that Ser27, Ser41, and Ser139 are in vivo Cdc7/Dbf4 phosphorylation sites in MCM2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-259848 Ser27 GNDPLTSsPGRSSRR Homo sapiens
pmid sentence
Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. | Because MCM2 was phosphorylated in vivo at Ser27, Ser41, and Ser139, which were phosphorylated by Cdc7/Dbf4 in vitro, the results suggested that Ser27, Ser41, and Ser139 are in vivo Cdc7/Dbf4 phosphorylation sites in MCM2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-259849 Ser41 RTDALTSsPGRDLPP Homo sapiens
pmid sentence
Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. | Because MCM2 was phosphorylated in vivo at Ser27, Ser41, and Ser139, which were phosphorylated by Cdc7/Dbf4 in vitro, the results suggested that Ser27, Ser41, and Ser139 are in vivo Cdc7/Dbf4 phosphorylation sites in MCM2.
Publications: 3 Organism: Homo Sapiens
+ CDK7down-regulates img/direct_inhibition.png phosphorylation POLR2A 0.789
Identifier Residue Sequence Organism Cell Line
SIGNOR-119992 Ser1619 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-119996 Ser1626 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120000 Ser1647 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120004 Ser1654 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120008 Ser1668 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120012 Ser1675 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120016 Ser1696 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120020 Ser1717 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120024 Ser1724 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120028 Ser1738 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120032 Ser1766 SPSYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120036 Ser1787 SPNYSPTsPSYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120040 Ser1864 SPKYSPTsPKYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120044 Ser1871 SPKYSPTsPKYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120048 Ser1882 SPTSPTYsPTTPKYS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120052 Ser1892 TPKYSPTsPTYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120056 Ser1899 SPTYSPTsPVYTPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120060 Ser1913 SPKYSPTsPTYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120064 Ser1920 SPTYSPTsPKYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120068 Ser1927 SPKYSPTsPTYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120072 Ser1934 SPTYSPTsPKGSTYS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120076 Ser1944 GSTYSPTsPGYSPTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Identifier Residue Sequence Organism Cell Line
SIGNOR-120080 Ser1951 SPGYSPTsPTYSLTS Homo sapiens
pmid sentence
Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Publications: 23 Organism: Homo Sapiens
+ CyclinA2/CDK2up-regulates activity img/direct-activation.png phosphorylation CDK7 0.643
Identifier Residue Sequence Organism Cell Line
SIGNOR-270807 Ser164 GLAKSFGsPNRAYTH in vitro
pmid sentence
Activating phosphorylation of CDK7 by CDC2 and CDK2. The ability of pure CDK2-cyclin A to activate CDK7 in T170-dependent fashion (Fig. ​(Fig.3C,3C, lane 2) strongly suggested a direct phosphorylation mechanism. Tryptic phosphopeptide mapping confirmed that both CDK2-cyclin A (Fig. ​(Fig.4A)4A) and CDC2-cyclin B (Fig. ​(Fig.4D)4D) phosphorylated CDK7 on both S164 and T170.
Identifier Residue Sequence Organism Cell Line
SIGNOR-270806 Thr170 GSPNRAYtHQVVTRW in vitro
pmid sentence
Activating phosphorylation of CDK7 by CDC2 and CDK2. The ability of pure CDK2-cyclin A to activate CDK7 in T170-dependent fashion (Fig. ​(Fig.3C,3C, lane 2) strongly suggested a direct phosphorylation mechanism. Tryptic phosphopeptide mapping confirmed that both CDK2-cyclin A (Fig. ​(Fig.4A)4A) and CDC2-cyclin B (Fig. ​(Fig.4D)4D) phosphorylated CDK7 on both S164 and T170.
Publications: 2 Organism: In Vitro
+ CDK2 img/unknown.png phosphorylation CDK7 0.569
Identifier Residue Sequence Organism Cell Line
SIGNOR-84832 Ser164 GLAKSFGsPNRAYTH Homo sapiens
pmid sentence
Cdk2 phosphorylates serine-164 in the cdk7 t loop.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates img/direct-activation.png phosphorylation NR5A1 0.367
Identifier Residue Sequence Organism Cell Line
SIGNOR-157952 Ser203 EYPEPYAsPPQPGLP Homo sapiens
pmid sentence
In conclusion, our results indicate that cdk7, as part of the cak complex and tfiih, phosphorylates sf1 at s203 followed by increased transcriptional activity of sf1
Publications: 1 Organism: Homo Sapiens
+ CDK7 img/unknown.png phosphorylation PCGF6 0.305
Identifier Residue Sequence Organism Cell Line
SIGNOR-250769 Ser30 LPPPPPVsPPALTPA in vitro
pmid sentence
In addition, we find that serine 32 of MBLR is specifically phosphorylated during mitosis, most likely by CDK7, a component of the basal transcriptional machinery. | These results indicate that, at least in vitro, MBLR is a substrate for CDK7 phosphorylation.
Publications: 1 Organism: In Vitro
+ CDK7 img/unknown.png phosphorylation TP53 0.46
Identifier Residue Sequence Organism Cell Line
SIGNOR-53311 Ser33 LPENNVLsPLPSQAM Homo sapiens
pmid sentence
We have mapped a major site of phosphorylation by cak to ser-33 of p53 and have demonstrated as well that p53 is phosphorylated at this site in vivo.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates img/direct-activation.png phosphorylation TP53 0.46
Identifier Residue Sequence Organism Cell Line
SIGNOR-51280 Ser371 AHSSHLKsKKGQSTS Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro. serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-51284 Ser376 LKSKKGQsTSRHKKL Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro. serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-51288 Ser378 SKKGQSTsRHKKLMF Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro. serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-51292 Ser392 FKTEGPDsD Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro. serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Publications: 4 Organism: Homo Sapiens
+ CDK7down-regulates img/direct_inhibition.png phosphorylation E2F1 0.495
Identifier Residue Sequence Organism Cell Line
SIGNOR-69776 Ser403 PEEFISLsPPHEALD Homo sapiens
pmid sentence
These results suggest that tfiih-mediated phosphorylation of e2f-1 plays a role in triggering e2f-1 degradation during s phase. here we show that the e2f-1 activation domain interacts with a kinase activity which phosphorylates two sites, ser403 and thr433, within the activation domain.
Identifier Residue Sequence Organism Cell Line
SIGNOR-69780 Thr433 DCDFGDLtPLDF Homo sapiens
pmid sentence
These results suggest that tfiih-mediated phosphorylation of e2f-1 plays a role in triggering e2f-1 degradation during s phase. here we show that the e2f-1 activation domain interacts with a kinase activity which phosphorylates two sites, ser403 and thr433, within the activation domain.
Publications: 2 Organism: Homo Sapiens
+ CDK7down-regulates img/direct_inhibition.png phosphorylation AR 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-170599 Ser516 VSRVPYPsPTCVKSE Homo sapiens
pmid sentence
Here, we show that the transcription factor tfiih, via its cdk7 kinase, phosphorylates the androgen receptor (ar) at position ar/s515. Strikingly, this phosphorylation is a key step for an accurate transactivation that includes the cyclic recruitment of the transcription machinery, the mdm2 e3 ligase, the subsequent ubiquitination of ar at the promoter of target genes and its degradation by the proteasome machinery
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates activity img/direct-activation.png phosphorylation RARG 0.416
Identifier Residue Sequence Organism Cell Line
SIGNOR-259853 Ser77 SEEMVPSsPSPPPPP Chlorocebus aethiops
pmid sentence
RARg Is Phosphorylated by cdk7 in Its B and F Regions | Mutation into alanine of Ser-77 and Ser-79 located in the A/B region reduced the transcriptional activity of hRARg1 (Fig. 9A), confirming that these phosphorylation sites are required for optimal transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277897 Ser79 EMVPSSPsPPPPPRV Chlorocebus aethiops COS-1 Cell
pmid sentence
That phosphorylation of serines 77 and 79 by cdk7 could be responsible for efficient transcription was further supported by the observation that overexpressed cdk7 significantly enhanced transcription by hRARγ1WT but not by hRARγ1S77A/S79A (Fig. 9 B). 
Identifier Residue Sequence Organism Cell Line
SIGNOR-259852 Ser79 EMVPSSPsPPPPPRV Chlorocebus aethiops
pmid sentence
RARg Is Phosphorylated by cdk7 in Its B and F Regions | Mutation into alanine of Ser-77 and Ser-79 located in the A/B region reduced the transcriptional activity of hRARg1 (Fig. 9A), confirming that these phosphorylation sites are required for optimal transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277896 Ser79 EMVPSSPsPPPPPRV Chlorocebus aethiops COS-1 Cell
pmid sentence
That phosphorylation of serines 77 and 79 by cdk7 could be responsible for efficient transcription was further supported by the observation that overexpressed cdk7 significantly enhanced transcription by hRARγ1WT but not by hRARγ1S77A/S79A (Fig. 9 B). 
Publications: 4 Organism: Chlorocebus Aethiops
+ CDK7 img/unknown.png phosphorylation RARA 0.544
Identifier Residue Sequence Organism Cell Line
SIGNOR-116582 Ser77 EIVPSPPsPPPLPRI Homo sapiens
pmid sentence
Thus, we demonstrate that the cdk7 kinase of tfiih phosphorylates the nuclear receptor, then allowing ligand-dependent control of the activation of the hormone-responsive genes.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates img/direct-activation.png phosphorylation RARA 0.544
Identifier Residue Sequence Organism Cell Line
SIGNOR-49693 Ser77 EIVPSPPsPPPLPRI Homo sapiens HeLa Cell
pmid sentence
However, only the coexpression of cdk7 stimulated ser-77 phosphorylation in vivo and enhanced transactivation by rar alpha, but not by a s77a rar mutant.
Publications: 1 Organism: Homo Sapiens
+ CDK7down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ERCC3 0.895
Identifier Residue Sequence Organism Cell Line
SIGNOR-277433 Ser90 HIFLEAFsPVYKYAQ Homo sapiens HeLa Cell
pmid sentence
These results led us to propose a model that spironolactone may trigger the phosphorylation of XPB at Ser90 by CDK7, which promotes the recognition and polyubiquitination of XPB by SCFFBXL18 for proteasomal degradation.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates activity img/direct-activation.png phosphorylation CDK2 0.569
Identifier Residue Sequence Organism Cell Line
SIGNOR-250768 Thr160 GVPVRTYtHEVVTLW in vitro
pmid sentence
Phosphorylation of monomeric human CDK2 by CAK1 is more efficient than phosphorylation of the binary CDK2-cyclin A complex. Phosphorylated CDK2 exhibits histone H1 kinase activity corresponding to approximately 0.3% of that observed with the fully activated phosphorylated CDK2-cyclin A complex. Fluorescence measurements have shown that Thr160 phosphorylation increases the affinity of CDK2 for both histone substrate and ATP and decreases its affinity for ADP.
Publications: 1 Organism: In Vitro
+ CDK7up-regulates img/direct-activation.png phosphorylation CDK1 0.579
Identifier Residue Sequence Organism Cell Line
SIGNOR-38307 Thr161 GIPIRVYtHEVVTLW Homo sapiens
pmid sentence
The mo15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (cdks) through phosphorylation of thr161 and its homologues
Publications: 1 Organism: Homo Sapiens
+ CDK2up-regulates img/direct-activation.png phosphorylation CDK7 0.569
Identifier Residue Sequence Organism Cell Line
SIGNOR-85013 Thr170 GSPNRAYtHQVVTRW Homo sapiens
pmid sentence
Threonine-170 of cdk7 is phosphorylated in vitro by cdk2. Full activation of cdk7 requires phorylation of a conserved threonine residue at position 170 in its own t loop.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates img/direct-activation.png phosphorylation CDK4 0.585
Identifier Residue Sequence Organism Cell Line
SIGNOR-36549 Thr172 YSYQMALtPVVVTLW Homo sapiens
pmid sentence
Phosphorylation of cdk4 on threonine 172 by a cdk-activating kinase (cak). therefore, formation of the cyclin d-cdk4 complex and phosphorylation of the bound catalytic subunit are independently regulated, and in addition to the requirement for cak activity, serum stimulation is required to promote assembly of the complexes in mammalian cells.
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates activity img/direct-activation.png phosphorylation XRN2 0.247
Identifier Residue Sequence Organism Cell Line
SIGNOR-259851 Thr439 FTPSGILtPHALGSR Homo sapiens
pmid sentence
CDKs and Xrn2 phosphorylation promote transcription termination. | Cdk7 phosphorylated Xrn2-Thr439 but was less efficient than Cdk9. |
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates activity img/direct-activation.png phosphorylation CDK11B 0.336
Identifier Residue Sequence Organism Cell Line
SIGNOR-245871 Thr595 GSPLKAYtPVVVTLW Homo sapiens HeLa Cell
pmid sentence
We conclude that CDK7 phsphorylates Cdk11, dependent on the conserved Thr219 residue in the CDK11 T loop, and it is therefore likely to be a genuine Cdk11 activating kinase
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates activity img/direct-activation.png phosphorylation CDK12 0.508
Identifier Residue Sequence Organism Cell Line
SIGNOR-275509 Thr893 SEESRPYtNKVITLW
pmid sentence
Although Cdk12/CycK kinase complex lacking T-loop phosphorylation showed some basal activity towards a CTD substrate prephosphorylated at position Ser7, its activity was significantly increased upon coexpression with the CAK from S. cerevisiae (Supplementary Fig. 9a). Mutation of T893 to E to mimic phosphorylation showed no effect on basal kinase activity. Quantitative phosphorylation of a single residue occurred upon coexpression with Cak1, as determined by ESI mass spectrometry (Supplementary Fig. 9b).
Publications: 1
+ PHA-767491down-regulates img/direct_inhibition.png chemical inhibition CDK7 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-206112 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamidedown-regulates img/direct_inhibition.png chemical inhibition CDK7 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-206136 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ CDK7form complex img/form-complex.png binding CAK complex 0.959
Identifier Residue Sequence Organism Cell Line
SIGNOR-269319 Homo sapiens
pmid sentence
CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits
Publications: 1 Organism: Homo Sapiens
+ BS-181 hydrochloridedown-regulates img/direct_inhibition.png chemical inhibition CDK7 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-190783 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamidedown-regulates img/direct_inhibition.png chemical inhibition CDK7 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-207087 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ alvocidibdown-regulates img/direct_inhibition.png chemical inhibition CDK7 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-192446 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
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