Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKCI	CDK7	Thr170 View in OncoXplorer	GSPNRAYtHQVVTRW	phosphorylation up-regulates activity	31784510	SIGNOR-280088
CDK2	CDK7	Ser164 View in OncoXplorer	GLAKSFGsPNRAYTH	phosphorylation unknown	11113184	SIGNOR-84832
CyclinA2/CDK2	CDK7	Ser164 View in OncoXplorer	GLAKSFGsPNRAYTH	phosphorylation up-regulates activity	11113184	SIGNOR-270807
CyclinA2/CDK2	CDK7	Thr170 View in OncoXplorer	GSPNRAYtHQVVTRW	phosphorylation up-regulates activity	11113184	SIGNOR-270806
CDK2	CDK7	Thr170 View in OncoXplorer	GSPNRAYtHQVVTRW	phosphorylation up-regulates	11113184	SIGNOR-85013

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKCI	phosphorylation up-regulates →	CDK7 PThr170	phosphorylation up-regulates →	CDK7	31784510	SIGNOR-280088
CDK2	phosphorylation up-regulates →	CDK7 PSer164	phosphorylation down-regulates ⊣	CDK7	11113184	SIGNOR-84832
CyclinA2/CDK2	phosphorylation up-regulates →	CDK7 PSer164	phosphorylation up-regulates →	CDK7	11113184	SIGNOR-270807
CyclinA2/CDK2	phosphorylation up-regulates →	CDK7 PThr170	phosphorylation up-regulates →	CDK7	11113184	SIGNOR-270806
CDK2	phosphorylation up-regulates →	CDK7 PThr170	phosphorylation up-regulates →	CDK7	11113184	SIGNOR-85013

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKCI	phosphorylation → up-regulates activity	CDK7	SIGNOR-280088
CDK2	phosphorylation → unknown	CDK7	SIGNOR-84832
CyclinA2/CDK2	phosphorylation → up-regulates activity	CDK7	SIGNOR-270807
CyclinA2/CDK2	phosphorylation → up-regulates activity	CDK7	SIGNOR-270806
CDK2	phosphorylation → up-regulates	CDK7	SIGNOR-85013