| Name | NEK2 |
| ID | P51955 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 8-271 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NEK2 | NDC80 | Ser165 | LGYPFALsKSSMYTV | phosphorylation up-regulates | 12386167 | SIGNOR-94322 |
| NEK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation down-regulates | 30266789 | SIGNOR-278488 |
| NEK2 | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates quantity | 30968157 | SIGNOR-278173 |
| NEK2 | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates quantity | 30968157 | SIGNOR-278172 |
| NEK2 | PPP1CC | Thr307 | EKKKPNAtRPVTPPR | phosphorylation down-regulates | 10880350 | SIGNOR-78306 |
| NEK2 | PPP1CC | Thr318 | TPPRGMItKQAKK | phosphorylation down-regulates | 10880350 | SIGNOR-78603 |
| NEK2 | YAP1 | Thr143 | AVSPGTLtPTGVVSG | phosphorylation up-regulates quantity by stabilization | 35705994 | SIGNOR-276586 |
| NEK2 | NEK2 | Ser241 | RRIPYRYsDELNEII | phosphorylation down-regulates | 17197699 | SIGNOR-151767 |
| NEK2 | NEK2 | Thr179 | FAKTFVGtPYYMSPE | phosphorylation down-regulates | 17197699 | SIGNOR-151771 |
| NEK2 | NEK2 | Ser171 | RILNHDTsFAKTFVG | phosphorylation up-regulates | 17197699 | SIGNOR-151755 |
| NEK2 | NEK2 | Thr170 | ARILNHDtSFAKTFV | phosphorylation up-regulates | 17197699 | SIGNOR-151759 |
| NEK2 | NEK2 | Thr175 | HDTSFAKtFVGTPYY | phosphorylation up-regulates | 17197699 | SIGNOR-151763 |
| NEK2 | SRSF1 | – | phosphorylation down-regulates activity | 24369428 | SIGNOR-279344 | |
| NEK2 | CDC20 | – | phosphorylation up-regulates activity | 20034488 | SIGNOR-278366 | |
| NEK2 | MAD2L1 | – | phosphorylation down-regulates activity | 20034488 | SIGNOR-278446 | |
| NEK2 | NCAPD2 | – | phosphorylation down-regulates activity | 25704143 | SIGNOR-279234 | |
| NEK2 | SGO1 | Ser14 | LKKSFQDsLEDIKKR | phosphorylation up-regulates | 17621308 | SIGNOR-156878 |
| NEK2 | SGO1 | Ser507 | TDLCFLNsPIFKQKK | phosphorylation up-regulates | 17621308 | SIGNOR-156882 |
| NEK2 | KIF24 | – | phosphorylation up-regulates activity | 26290419 | SIGNOR-278413 | |
| NEK2 | CCDC102B | – | phosphorylation down-regulates activity | 30404835 | SIGNOR-275626 | |
| NEK2 | CEP68 | – | phosphorylation down-regulates quantity by destabilization | 25704143 | SIGNOR-279471 | |
| NEK2 | CNTROB | – | phosphorylation down-regulates activity | 23291182 | SIGNOR-279545 | |
| NEK2 | NEK11 | – | phosphorylation up-regulates | 15161910 | SIGNOR-124944 | |
| NEK2 | LRRC45 | Ser661 | VLAYVQAsPVRTLSP | phosphorylation down-regulates activity | 24035387 | SIGNOR-273707 |
| NEK2 | GAS2L1 | Ser352 | HPRSRRYsGDSDSSA | phosphorylation up-regulates activity | 32289147 | SIGNOR-273683 |
| NEK2 | CEP250 | Ser2392 | AGLHHSLsHSLLAVA | phosphorylation down-regulates | 24695856 | SIGNOR-204833 |
| NEK2 | CEP250 | Ser2394 | LHHSLSHsLLAVAQA | phosphorylation down-regulates | 24695856 | SIGNOR-204837 |
| NEK2 | CD274 | Thr194 | EEKLFNVtSTLRINT | phosphorylation up-regulates quantity by stabilization | 34315872 | SIGNOR-277315 |
| NEK2 | CD274 | Thr210 | TNEIFYCtFRRLDPE | phosphorylation up-regulates quantity by stabilization | 34315872 | SIGNOR-277314 |
| NEK2 | SUFU | – | phosphorylation up-regulates activity | 27297360 | SIGNOR-279235 | |
| NEK2 | PP1 | – | phosphorylation down-regulates | 10880350 | SIGNOR-264655 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NEK2 | phosphorylation up-regulates → | NDC80 PSer165 | phosphorylation up-regulates → | NDC80 | 12386167 | SIGNOR-94322 |
| NEK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation down-regulates ⊣ | TP53 | 30266789 | SIGNOR-278488 |
| NEK2 | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 30968157 | SIGNOR-278173 |
| NEK2 | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 30968157 | SIGNOR-278172 |
| NEK2 | phosphorylation up-regulates → | PPP1CC PThr307 | phosphorylation down-regulates ⊣ | PPP1CC | 10880350 | SIGNOR-78306 |
| NEK2 | phosphorylation up-regulates → | PPP1CC PThr318 | phosphorylation down-regulates ⊣ | PPP1CC | 10880350 | SIGNOR-78603 |
| NEK2 | phosphorylation up-regulates → | YAP1 PThr143 | phosphorylation up-regulates → | YAP1 | 35705994 | SIGNOR-276586 |
| NEK2 | phosphorylation up-regulates → | NEK2 PSer241 | phosphorylation down-regulates ⊣ | NEK2 | 17197699 | SIGNOR-151767 |
| NEK2 | phosphorylation up-regulates → | NEK2 PThr179 | phosphorylation down-regulates ⊣ | NEK2 | 17197699 | SIGNOR-151771 |
| NEK2 | phosphorylation up-regulates → | NEK2 PSer171 | phosphorylation up-regulates → | NEK2 | 17197699 | SIGNOR-151755 |
| NEK2 | phosphorylation up-regulates → | NEK2 PThr170 | phosphorylation up-regulates → | NEK2 | 17197699 | SIGNOR-151759 |
| NEK2 | phosphorylation up-regulates → | NEK2 PThr175 | phosphorylation up-regulates → | NEK2 | 17197699 | SIGNOR-151763 |
| NEK2 | phosphorylation up-regulates → | SGO1 PSer14 | phosphorylation up-regulates → | SGO1 | 17621308 | SIGNOR-156878 |
| NEK2 | phosphorylation up-regulates → | SGO1 PSer507 | phosphorylation up-regulates → | SGO1 | 17621308 | SIGNOR-156882 |
| NEK2 | phosphorylation up-regulates → | LRRC45 PSer661 | phosphorylation down-regulates ⊣ | LRRC45 | 24035387 | SIGNOR-273707 |
| NEK2 | phosphorylation up-regulates → | GAS2L1 PSer352 | phosphorylation up-regulates → | GAS2L1 | 32289147 | SIGNOR-273683 |
| NEK2 | phosphorylation up-regulates → | CEP250 PSer2392 | phosphorylation down-regulates ⊣ | CEP250 | 24695856 | SIGNOR-204833 |
| NEK2 | phosphorylation up-regulates → | CEP250 PSer2394 | phosphorylation down-regulates ⊣ | CEP250 | 24695856 | SIGNOR-204837 |
| NEK2 | phosphorylation up-regulates → | CD274 PThr194 | phosphorylation up-regulates → | CD274 | 34315872 | SIGNOR-277315 |
| NEK2 | phosphorylation up-regulates → | CD274 PThr210 | phosphorylation up-regulates → | CD274 | 34315872 | SIGNOR-277314 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NEK2 | phosphorylation → up-regulates | NDC80 | SIGNOR-94322 |
| NEK2 | phosphorylation down-regulates | TP53 | SIGNOR-278488 |
| NEK2 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278173 |
| NEK2 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278172 |
| NEK2 | phosphorylation down-regulates | PPP1CC | SIGNOR-78306 |
| NEK2 | phosphorylation down-regulates | PPP1CC | SIGNOR-78603 |
| NEK2 | phosphorylation → up-regulates quantity by stabilization | YAP1 | SIGNOR-276586 |
| NEK2 | phosphorylation down-regulates | NEK2 | SIGNOR-151767 |
| NEK2 | phosphorylation down-regulates | NEK2 | SIGNOR-151771 |
| NEK2 | phosphorylation → up-regulates | NEK2 | SIGNOR-151755 |
| NEK2 | phosphorylation → up-regulates | NEK2 | SIGNOR-151759 |
| NEK2 | phosphorylation → up-regulates | NEK2 | SIGNOR-151763 |
| NEK2 | phosphorylation → down-regulates activity | SRSF1 | SIGNOR-279344 |
| NEK2 | phosphorylation → up-regulates activity | CDC20 | SIGNOR-278366 |
| NEK2 | phosphorylation → down-regulates activity | MAD2L1 | SIGNOR-278446 |
| NEK2 | phosphorylation → down-regulates activity | NCAPD2 | SIGNOR-279234 |
| NEK2 | phosphorylation → up-regulates | SGO1 | SIGNOR-156878 |
| NEK2 | phosphorylation → up-regulates | SGO1 | SIGNOR-156882 |
| NEK2 | phosphorylation → up-regulates activity | KIF24 | SIGNOR-278413 |
| NEK2 | phosphorylation → down-regulates activity | CCDC102B | SIGNOR-275626 |
| NEK2 | phosphorylation down-regulates quantity by destabilization | CEP68 | SIGNOR-279471 |
| NEK2 | phosphorylation → down-regulates activity | CNTROB | SIGNOR-279545 |
| NEK2 | phosphorylation → up-regulates | NEK11 | SIGNOR-124944 |
| NEK2 | phosphorylation → down-regulates activity | LRRC45 | SIGNOR-273707 |
| NEK2 | phosphorylation → up-regulates activity | GAS2L1 | SIGNOR-273683 |
| NEK2 | phosphorylation down-regulates | CEP250 | SIGNOR-204833 |
| NEK2 | phosphorylation down-regulates | CEP250 | SIGNOR-204837 |
| NEK2 | phosphorylation → up-regulates quantity by stabilization | CD274 | SIGNOR-277315 |
| NEK2 | phosphorylation → up-regulates quantity by stabilization | CD274 | SIGNOR-277314 |
| NEK2 | phosphorylation → up-regulates activity | SUFU | SIGNOR-279235 |
| NEK2 | phosphorylation down-regulates | PP1 | SIGNOR-264655 |