Summary

Name NEK2
Full Name Serine/threonine-protein kinase Nek2
Synonyms HSPK 21, Never in mitosis A-related kinase 2, NimA-related protein kinase 2, NimA-like protein kinase 1 | NEK2A, NLK1
Primary ID P51955
Links - -
Type protein
Relations 30
Function Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation SGO1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NDC80 0.596
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NEK2 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEP250 0.774
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NEK2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CTNNB1 0.472
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAS2L1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NEK2 0.244
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation LRRC45 0.373
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation YAP1 0.2
Publications: 1
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CD274 0.2
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation PPP1CC 0.491
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CCDC102B 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png dephosphorylation NEK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation NEK2 0.375
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PP1 0.492
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NEK11 0.395
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAD2L1 0.843
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDC20 0.944
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization NEK2 0.421
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KIF24 0.694
Publications: 1 Organism: Homo Sapiens