Summary

Name NEK2
Full Name Serine/threonine-protein kinase Nek2
Synonyms HSPK 21, Never in mitosis A-related kinase 2, NimA-related protein kinase 2, NimA-like protein kinase 1 | NEK2A, NLK1
Primary ID P51955
Links - -
Type protein
Relations 16
Function Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation SGO1 0.64
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NDC80 0.95
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NEK2
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEP250
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NEK2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NEK2 0.92
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP1CC 0.90
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation NEK2 0.83
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization NEK2 0.93
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NEK11 0.81
Publications: 1 Organism: Homo Sapiens