| + |
NEK2 | up-regulates 
phosphorylation
|
SGO1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156878 |
Ser14 |
LKKSFQDsLEDIKKR |
Homo sapiens |
|
| pmid |
sentence |
| 17621308 |
Here we show that nek2a phosphorylates human sgo1 and such phosphorylation is essential for faithful chromosome congression in mitosis. phosphorylation sites were mapped to ser(14) and ser(507) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156882 |
Ser507 |
TDLCFLNsPIFKQKK |
Homo sapiens |
|
| pmid |
sentence |
| 17621308 |
Here we show that nek2a phosphorylates human sgo1 and such phosphorylation is essential for faithful chromosome congression in mitosis. phosphorylation sites were mapped to ser(14) and ser(507) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NEK2 | up-regulates
phosphorylation
|
NDC80 |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94322 |
Ser165 |
LGYPFALsKSSMYTV |
Homo sapiens |
|
| pmid |
sentence |
| 12386167 |
Phosphorylation of the mitotic regulator protein hec1 by nek2 kinase is essential for faithful chromosome segregation.Hec1 (highly expressed in cancer) plays essential roles in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the g(2)/m phase.Nek2 phosphorylates hec1 on serine residue 165, both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEK2 | up-regulates
phosphorylation
|
NEK2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151755 |
Ser171 |
RILNHDTsFAKTFVG |
Homo sapiens |
|
| pmid |
sentence |
| 17197699 |
Enzymatic activity, induced; |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151759 |
Thr170 |
ARILNHDtSFAKTFV |
Homo sapiens |
|
| pmid |
sentence |
| 17197699 |
Thus, it appears that autophosphorylation of thr-170 and/or ser-171 in nek2 may fine-tune overall activity of nek2 in vivo. regardless, the importance of thr-175 suggested by its conservation in many other kinases is underlined by the t175a mutant that shows reduced kinase activity and a significant reduction in efficiency of cs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151763 |
Thr175 |
HDTSFAKtFVGTPYY |
Homo sapiens |
|
| pmid |
sentence |
| 17197699 |
Enzymatic activity, induced; |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
NEK2 | down-regulates 
phosphorylation
|
CEP250 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204833 |
Ser2392 |
AGLHHSLsHSLLAVA |
Homo sapiens |
|
| pmid |
sentence |
| 24695856 |
Our data support a model in which centrosome disjunction is triggered by the hyperphosphorylation of c-nap1, a major linker component. This occurs in response to a shift in the balance of activities of the nek2?_Pp1 bi-stable switch. C-nap1 hyperphosphorylation triggers the loss of both oligomerization and, crucially, interaction with the core centriole proximal-end protein, cep135. All three of these sites were identified in our in vivo analysis but only two (s2234 and s2394) were identified as nek2 phosphorylation sites in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204837 |
Ser2394 |
LHHSLSHsLLAVAQA |
Homo sapiens |
|
| pmid |
sentence |
| 24695856 |
C-nap1 hyperphosphorylation triggers the loss of both oligomerization and, crucially, interaction with the core centriole proximal-end protein, cep135. All three of these sites were identified in our in vivo analysis but only two (s2234 and s2394) were identified as nek2 phosphorylation sites in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NEK2 | down-regulates
phosphorylation
|
NEK2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151767 |
Ser241 |
RRIPYRYsDELNEII |
Homo sapiens |
|
| pmid |
sentence |
| 17197699 |
Enzymatic activity, inhibited; |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151771 |
Thr179 |
FAKTFVGtPYYMSPE |
Homo sapiens |
|
| pmid |
sentence |
| 17197699 |
Enzymatic activity, inhibited; |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STK3 | up-regulates
phosphorylation
|
NEK2 |
0.92 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169539 |
Ser438 |
EKNYQLKsRQILGMR |
Homo sapiens |
|
| pmid |
sentence |
| 21076410 |
Our data suggest that mst2 phosphorylates nek2a thereby recruiting nek2a to centrosomes and promoting phosphorylation and displacement of centrosomal linker proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEK2 | down-regulates
phosphorylation
|
PPP1CC |
0.90 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78306 |
Thr307 |
EKKKPNAtRPVTPPR |
Homo sapiens |
|
| pmid |
sentence |
| 10880350 |
Pp1 is a substrate for nek2 and phosphorylation of pp1gamma(1) on two c-terminal sites reduces its phosphatase activity. / threonine-307 and -318 appear to be equally well phosphorylated by nek2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78603 |
Thr318 |
TPPRGMItKQAKK |
Homo sapiens |
|
| pmid |
sentence |
| 10880350 |
Pp1 is a substrate for nek2 and phosphorylation of pp1gamma(1) on two c-terminal sites reduces its phosphatase activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PCM1 | up-regulates
relocalization
|
NEK2 |
0.93 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15659651 |
Recruitment of nek2 and c-nap1 to the centrosome is dependent on pcm-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEK2 | up-regulates
phosphorylation
|
NEK11 |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124944 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15161910 |
Nek2 directly phosphorylated nek11 in the c-terminal non-catalytic region and elevated nek11 kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CA | down-regulates
dephosphorylation
|
NEK2 |
0.83 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17283141 |
Nek2 is activated by autophosphorylation, and its dephosphorylation is catalyzed by pp1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
NEK2
- 
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